Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Cell Biology
Yuhang Xue, Kanqiu Jiang, Li Ou, Mingjing Shen, Yi Yang, Jingjing Lu, Weihua Xu
Summary: Targeting SphK1/2 with SKI-349 potently inhibits NSCLC cell growth both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Antonia Piazzesi, Sumaiya Yasmeen Afsar, Gerhild Van Echten-Deckert
Summary: Cancer development is a complex process involving overcoming obstacles such as unrestricted proliferation, invasion, nutrient supply, and metastasis, while evading the immune system. Inflammation plays a role in cancer development, with sphingolipid metabolism impacting cells' progression from healthy to cancerous phenotypes.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Alhaji H. Janneh, Besim Ogretmen
Summary: Sphingolipids, as important components of cell membranes, play critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral functions. This review highlights the mechanistic strategies of targeting sphingolipid metabolism for cancer therapeutics. Sphingolipid metabolic signaling plays crucial roles in regulating tumor progression and conferring resistance to anticancer therapies, especially through S1P, which promotes tumor growth/metastasis. Evaluating the prognostic value of sphingolipid enzymes in the overall survival of patients with different malignancies and their clinical implications for anticancer treatment is also discussed.
Review
Cell Biology
Federica Cirillo, Marco Piccoli, Andrea Ghiroldi, Michelle M. Monasky, Paola Rota, Paolo La Rocca, Adriana Tarantino, Sara D'Imperio, Paola Signorelli, Carlo Pappone, Luigi Anastasia
Summary: Cardiovascular diseases are a major cause of death globally, with an increasing number of patients posing challenges to healthcare systems. Sphingolipids have emerged as important bioactive compounds that play crucial roles in biological processes and have potential therapeutic implications for managing cardiovascular diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Arkadiusz Zbikowski, Piotr Zabielski, Urszula Chlabicz, Patrycja Sadowska, Karolina Pogodzinska, Agnieszka U. Blachnio-Zabielska
Summary: Silencing of SPHK1 expression decreases S1P content and increases apoptosis in HCT-116 colorectal cancer cells, while silencing of SGPL1 expression increases both S1P and Cer content and modulates Cathepsin-D. The S1P/Cer ratio seems to play a crucial role in cellular apoptosis and CRC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Bartlomiej Lukaszuk, Marta Lewoc, Hend Malla, Piotr Mysliwiec, Jacek Dadan, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex chronic immunologically mediated disease that affects the skin, nails, and joints. Abnormal levels of sphingolipids significantly differ between psoriatic skin and healthy skin, suggesting their potential role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Yanfei Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, Pu Xia
Summary: Sphingolipids play a crucial role in cell membrane structure and intracellular signaling pathways. Sphingosine kinase (SphK) is an important enzyme in sphingolipid metabolism, with implications in both physiological and pathological processes, including type 2 diabetes mellitus (T2D). There is ongoing debate about the specific role of SphK in T2D, but it is believed to be a potential target for future anti-diabetes therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Oncology
Purab Pal, Alec Millner, Svetlana E. Semina, Rosemary J. Huggins, Logan Running, Diana S. Aga, Debra A. Tonetti, Rachel Schiff, Geoffrey L. Greene, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: Endocrine therapy resistance is a critical problem in estrogen receptor-positive breast cancer. This study investigated how alterations in sphingolipids promote cell survival in ET-resistant breast cancer. Through targeted sphingolipidomics analysis, the researchers found that tamoxifen-resistant cells have lower levels of ceramides compared to their sensitive counterparts. They also identified that CERK inhibition induces ceramide-mediated cell death in tamoxifen-resistant cells. These findings suggest that ET-resistant breast cancer cells rely on CERK activity to maintain lower ceramide levels, making CERK a potential therapeutic target.
Review
Medicine, Research & Experimental
Haaris A. Shiwani, Mohammed Y. Elfaki, Danyal Memon, Suhayb Ali, Abdul Aziz, Emmanuel E. Egom
Summary: Sphingolipids such as Ceramide, Ceramide-1-phosphate, Sphingosine, and Sphingosine-1-phosphate are key signaling molecules that regulate various retinal processes, with potential dual biological effects in retinal diseases. Inhibitors targeting these sphingolipids have shown promise in preserving neuronal viability and retinal function, making them attractive therapeutic targets for retinal degenerations.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Peter Horvath, Lilla Budi, Daniel Hammer, Rita Varga, Gyoergy Losonczy, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Martina Meszaros, Andras Bikov
Summary: Chronic inflammation induced by hypoxia during sleep is an important mechanism of microvascular damage in OSA patients. This study examined the role of the sphingosine rheostat, which has various inflammatory effects. The results showed elevated levels of ceramide antibody and sphingosine-1-phosphate in patients with OSA, suggesting their involvement in the pathomechanism and comorbidities of OSA.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lorena Perez-Carrillo, Isaac Gimenez-Escamilla, Luis Martinez-Dolz, Ignacio Jose Sanchez-Lazaro, Manuel Portoles, Esther Rosello-Lleti, Estefania Tarazon
Summary: Disturbances in sphingolipid metabolism contribute to the development of heart failure by causing an accumulation of ceramide and S1P in cardiac tissue, as well as an increase in the ceramide/S1P ratio. Therapeutic gene modulation aimed at restoring ceramide levels or reversing the ceramide/S1P ratio could be a potential treatment strategy for heart failure patients.
Review
Biochemistry & Molecular Biology
Alec Millner, G. Ekin Atilla-Gokcumen
Summary: Sphingolipids are highly bioactive lipids that play key roles in cellular processes. They function as signaling molecules in cell death and survival, and their function can be understood through lipidomics and synthetic probe studies.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N. Chamcheu, Abu Bakar Siddique, Melissa B. Bloch, Sergette Banang Mbeumi, Abiola S. Babatunde, Mohammad B. Uddin, Felicite K. Noubissi, Peter W. Jurutka, Yong-Yu Liu, Vladimir S. Spiegelman, G. Kerr Whitfield, Khalid A. El Sayed
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Cardiac & Cardiovascular Systems
Wentao Fang, Yun Wang, Liewen Pang, Zhitao Gu, Yucheng Wei, Yongyu Liu, Peng Zhang, Chun Chen, Xinming Zhou, Yangchun Liu, Keneng Chen, Jianyong Ding, Yongtao Han, Yin Li, Zhentao Yu, Yuan Liu, Jianhua Fu
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2018)
Article
Oncology
Wen-Zhao Zhong, Qun Wang, Wei-Min Mao, Song-Tao Xu, Lin Wu, Yi Shen, Yong-Yu Liu, Chun Chen, Ying Cheng, Lin Xu, Jun Wang, Ke Fei, Xiao-Fei Li, Jian Li, Cheng Huang, Zhi-Dong Liu, Shun Xu, Ke-Neng Chen, Shi-Dong Xu, Lun-Xu Liu, Ping Yu, Bu-Hai Wang, Hai-Tao Ma, Hong-Hong Yan, Xue-Ning Yang, Qing Zhou, Yi-Long Wu
Article
Pharmacology & Pharmacy
Mohammad B. Uddin, Kartik R. Roy, Salman B. Hosain, Sachin K. Khiste, Ronald A. Hill, Seetharama D. Jois, Yunfeng Zhao, Alan J. Tackett, Yong-Yu Liu
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Oncology
Song-Tao Xu, Jun-Jie Xi, Wen-Zhao Zhong, Wei-Min Mao, Lin Wu, Yi Shen, Yong-Yu Liu, Chun Chen, Ying Cheng, Lin Xu, Jun Wang, Ke Fei, Xiao-Fei Li, Jian Li, Cheng Huang, Zhi-Dong Liu, Shun Xu, Ke-Neng Chen, Shi-Dong Xu, Lun-Xu Liu, Ping Yu, Bu-Hai Wang, Hai-Tao Ma, Hong-Hong Yan, Xue-Ning Yang, Yong-Xing Zhang, Jia-Cheng Yin, Qun Wang, Yi-Long Wu
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Nutrition & Dietetics
Abu Bakar Siddique, Hassan Y. Ebrahim, Mohamed R. Akl, Nehad M. Ayoub, Amira A. Goda, Mohamed M. Mohyeldin, Suresh K. Nagumalli, Wael M. Hananeh, Yong-Yu Liu, Sharon A. Meyer, Khalid A. El Sayed
Editorial Material
Respiratory System
Yousheng Mao, Zhentao Yu, Bin You, Wentao Fang, Brian Badgwell, Mark F. Berry, DuyKhanh P. Ceppa, Chun Chen, Haiquan Chen, Miguel A. Cuesta, Xavier Benoit D'Journo, Guy D. Eslick, Jianhua Fu, Xiangning Fu, Shugeng Gao, Jianxing He, Jie He, Yunchao Huang, Gening Jiang, Zhongmin Jiang, Jae Y. Kim, Danqing Li, Hui Li, Shanqing Li, Deruo Liu, Lunxu Liu, Yongyu Liu, Xiaofei Li, Yin Li, Weimin Mao, Daniela Molena, Christopher R. Morse, Nuria M. Novoa, Lijie Tan, Qunyou Tan, Alper Toker, Ti Tong, Qun Wang, Benny Weksler, Lin Xu, Shidong Xu, Tiansheng Yan, Lanjun Zhang, Xingyi Zhang, Xun Zhang, Zhu Zhang, Xiuyi Zhi, Qinghua Zhou
JOURNAL OF THORACIC DISEASE
(2019)
Review
Cell Biology
Jean Christopher Chamcheu, Tithi Roy, Mohammad Burhan Uddin, Sergette Banang-Mbeumi, Roxane-Cherille N. Chamcheu, Anthony L. Walker, Yong-Yu Liu, Shile Huang
Article
Oncology
Na Li, Lan Zhao, Chunyan Guo, Chang Liu, Yongyu Liu
CANCER MANAGEMENT AND RESEARCH
(2019)
Article
Oncology
Sachin K. Khiste, Zhijun Liu, Kartik R. Roy, Mohammad B. Uddin, Salman B. Hosain, Xin Gu, Sami Nazzal, Ronald A. Hill, Yong-Yu Liu
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Jianzhong Chen, Sachin K. Khiste, Xiaomei Fu, Kartik R. Roy, Yixuan Dong, Jian Zhang, Mei Liu, Yong-Yu Liu, Zhijun Liu
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2020)
Article
Oncology
Zhengjun Li, Wei Chen, Mozhu Xia, Hongxu Liu, Yongyu Liu, Ilhan Inci, Fabio Davoli, Ryuichi Waseda, Pier Luigi Filosso, Abby White
TRANSLATIONAL LUNG CANCER RESEARCH
(2019)
Editorial Material
Oncology
Ronald A. Hill, Yong-Yu Liu
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Sagor C. Roy, Xin Gu, Li Li, Qian-Jin Zhang, Zongbing You, Yong-Yu Liu
Summary: Mutant p53 suppresses NK cell activation, allowing breast cancer cells to escape immune attack. Wildtype p53 is necessary for NK cell recognition and elimination of cancer cells, while p53 mutations impair NK cell responses.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kartik R. Roy, Mohammad B. Uddin, Sagor C. Roy, Ronald A. Hill, John Marshall, Yu-Teh Li, Jean Christopher Chamcheu, Hua Lu, Yong-Yu Liu
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)