α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

CAR-NK cells: A promising cellular immunotherapy for cancer

(2020) Guozhu Xie et al.   EBioMedicine

Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study

(2019) Edward B. Garon et al.   JOURNAL OF CLINICAL ONCOLOGY

α-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells

(2019) Jing Hou et al.   MEDICAL SCIENCE MONITOR

The RAC2-PI3K axis regulates human NK cell maturation and function

(2019) Giovanna Tabellini et al.   CLINICAL IMMUNOLOGY

Anti-tumor activities and mechanism study of α-pinene derivative in vivo and in vitro

(2019) Lianbao Ye et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

(2018) Qing Zhang et al.   NATURE IMMUNOLOGY

Regulation of Human Natural Killer Cell IFN-γ Production by MicroRNA-146a via Targeting the NF-κB Signaling Pathway

(2018) Hongwei Wang et al.   Frontiers in Immunology

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

A possible new pathway in natural killer cell activation also reveals the difficulty in determining human NK cell function in cancer

(2018) Robert J. Canter et al.   Journal for ImmunoTherapy of Cancer

α-pinene regulates miR-221 and induces G2/M phase cell cycle arrest in human hepatocellular carcinoma cells

(2018) Qiuxiang Xu et al.   BIOSCIENCE REPORTS

NK Cell-Based Immunotherapy in Cancer Metastasis

(2018) Seila Lorenzo-Herrero et al.   Cancers

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27

(2017) Norberto Walter Zwirner et al.   Frontiers in Immunology

CD56 in the Immune System: More Than a Marker for Cytotoxicity?

(2017) Heleen H. Van Acker et al.   Frontiers in Immunology

Effect of Phytoncide from Trees on Human Natural Killer Cell Function

(2017) Q. Li et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma

(2016) M. Carlsten et al.   CLINICAL CANCER RESEARCH

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

(2016) Hyung-Joon Kwon et al.   Nature Communications

Role of IL-2 in cancer immunotherapy

(2016) Tao Jiang et al.   OncoImmunology

Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia

(2016) Emily M. McWilliams et al.   OncoImmunology

α-Pinene inhibits tumor invasion through downregulation of nuclear factor (NF)-κB-regulated matrix metalloproteinase-9 gene expression in MDA-MB-231 human breast cancer cells

(2016) Eunah Kang et al.   Applied Biological Chemistry

Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

(2015) Liyun Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

(2015) Weiqiang Chen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy

(2015) Cariad Chester et al.   Frontiers in Immunology

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

(2014) Saar Gill et al.   IMMUNOLOGICAL REVIEWS

Antitumor Activity of Monoterpenes Found in Essential Oils

(2014) Marianna Vieira Sobral et al.   TheScientificWorldJOURNAL

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

(2014) I. P. da Silva et al.   Cancer Immunology Research

The enhanced effect of lupeol on the destruction of gastric cancer cells by NK cells

(2013) Xiao-Ting Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA

(2013) Baris E. Dayanc et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

(2013) Chong Wang et al.   TheScientificWorldJOURNAL

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

(2011) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

Composition and Mechanism of Antitumor Effects ofHericium erinaceusMushroom Extracts in Tumor-Bearing Mice

(2011) Sung Phil Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells

(2009) F. Romagne et al.   BLOOD

Hormones in the naso-oropharynx: endocrine modulation of taste and smell

(2009) Bronwen Martin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Early Lymphocyte Recovery Predicts Superior Survival after Autologous Stem Cell Transplantation in Non-Hodgkin Lymphoma: A Prospective Study

(2008) Luis F. Porrata et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CD56brightnatural killer (NK) cells: an important NK cell subset

(2008) Aurélie Poli et al.   IMMUNOLOGY

Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma

(2008) John A. Thompson et al.   JOURNAL OF CLINICAL ONCOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY