Extracellular Vesicles-Encapsulated Yeast Prions and What They Can Tell Us about the Physical Nature of Propagons

Intracellular vesicle clusters are organelles that synthesize extracellular vesicle–associated cargo proteins in yeast

(2020) Chelsea M. Winters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose availability dictates the export of the soluble and prion forms of Sup35p via periplasmic or extracellular vesicles

(2020) Mehdi Kabani et al.   MOLECULAR MICROBIOLOGY

The actin cytoskeletal network plays a role in yeast prion transmission and contributes to prion stability

(2020) Jane E. Dorweiler et al.   MOLECULAR MICROBIOLOGY

Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast

(2020) Janice Villali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Do Yeast Cells Contend with Prions?

(2020) Reed B. Wickner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prion Amyloid Polymorphs – The Tag Might Change It All

(2020) Luc Bousset et al.   Frontiers in Molecular Biosciences

Growth phase-dependent changes in the size and infectivity of SDS-resistant Sup35p assemblies associated with the [PSI + ] prion in yeast

(2019) Kai Wang et al.   MOLECULAR MICROBIOLOGY

A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program

(2019) Anupam K. Chakravarty et al.   MOLECULAR CELL

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

A two-way road: novel roles for fungal extracellular vesicles

(2018) Marcio L. Rodrigues et al.   MOLECULAR MICROBIOLOGY

Mechanics and regulation of cytokinesis in budding yeast

(2017) Yogini P. Bhavsar-Jog et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

De novo [PSI +] prion formation involves multiple pathways to form infectious oligomers

(2017) Jaya Sharma et al.   Scientific Reports

Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress

(2017) Tatiana A. Chernova et al.   Cell Reports

Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation

(2017) Shaun H. Speldewinde et al.   PLoS Genetics

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast

(2017) Kai Wang et al.   PLoS One

The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae

(2016) Maria Angeles Juanes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prions, Chaperones, and Proteostasis in Yeast

(2016) Tatiana A. Chernova et al.   Cold Spring Harbor Perspectives in Biology

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions

(2016) Sandra Malmgren Hill et al.   Cell Reports

Prion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular Transport

(2016) Rajesh Kumar et al.   PLoS Genetics

More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions

(2015) Mehdi Kabani et al.   CURRENT GENETICS

Sharing the cell's bounty - organelle inheritance in yeast

(2015) B. Knoblach et al.   JOURNAL OF CELL SCIENCE

Yeast Prions: Structure, Biology, and Prion-Handling Systems

(2015) Reed B. Wickner et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Yeast prions: Paramutation at the protein level?

(2015) Mick F. Tuite   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sup35p in Its Soluble and Prion States Is Packaged inside Extracellular Vesicles

(2015) Mehdi Kabani et al.   mBio

Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism

(2015) Fatih Arslan et al.   PLoS Genetics

An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists

(2014) Daniel F. Jarosz et al.   CELL

Role of asymmetric cell division in lifespan control inSaccharomyces cerevisiae

(2014) Ryo Higuchi-Sanabria et al.   FEMS YEAST RESEARCH

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

A role for the proteasome in the turnover of Sup35p and in [PSI+] prion propagation

(2014) Mehdi Kabani et al.   MOLECULAR MICROBIOLOGY

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Glucose induces rapid changes in the secretome of Saccharomyces cerevisiae

(2014) Bennett J Giardina et al.   Proteome Science

Solid-state NMR sequential assignments of the amyloid core of full-length Sup35p

(2013) Anne K. Schütz et al.   Biomolecular NMR Assignments

Rebels with a cause: molecular features and physiological consequences of yeast prions

(2013) David M. Garcia et al.   FEMS YEAST RESEARCH

Spontaneous Variants of the [RNQ+] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins

(2013) Vincent J. Huang et al.   PLoS One

Blessings in disguise: biological benefits of prion-like mechanisms

(2013) Gregory A. Newby et al.   TRENDS IN CELL BIOLOGY

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Yeast prions assembly and propagation: Contributions of the prion and non-prion moieties and the nature of assemblies

(2012) Mehdi Kabani et al.   Prion

The yeast prions [PSI+] and [URE3] are molecular degenerative diseases

(2012) Reed B. Wickner et al.   Prion

Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures

(2012) H. R. Saibil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Motility and Segregation of Hsp104-Associated Protein Aggregates in Budding Yeast

(2011) Chuankai Zhou et al.   CELL

Segregation of Protein Aggregates Involves Actin and the Polarity Machinery

(2011) Beidong Liu et al.   CELL

A mutation within the C-terminal domain of Sup35p that affects [PSI+] prion propagation

(2011) Mehdi Kabani et al.   MOLECULAR MICROBIOLOGY

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis

(2011) David S. Wald et al.   PLoS One

Suicidal [PSI+] is a lethal yeast prion

(2011) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

(2011) Anita L. Manogaran et al.   PLoS Genetics

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

(2010) Beidong Liu et al.   CELL

Analysis of the [RNQ+] Prion Reveals Stability of Amyloid Fibers as the Key Determinant of Yeast Prion Variant Propagation

(2010) Tejas Kalastavadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analyzing the Birth and Propagation of Two Distinct Prions, [PSI+] and [Het-s]y, in Yeast

(2010) Vidhu Mathur et al.   MOLECULAR BIOLOGY OF THE CELL

In Sup35p filaments (the [PSI+] prion), the globular C-terminal domains are widely offset from the amyloid fibril backbone

(2010) Ulrich Baxa et al.   MOLECULAR MICROBIOLOGY

Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1

(2010) T. Rogoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity

(2010) Aaron Derdowski et al.   SCIENCE

Prions, protein homeostasis, and phenotypic diversity

(2010) Randal Halfmann et al.   TRENDS IN CELL BIOLOGY

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Prion dynamics and the quest for the genetic determinant in protein-only inheritance

(2009) Suzanne S Sindi et al.   CURRENT OPINION IN MICROBIOLOGY

The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins

(2009) P. Tessarz et al.   MOLECULAR AND CELLULAR BIOLOGY

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

(2009) Basant K. Patel et al.   NATURE CELL BIOLOGY

The Number and Transmission of [PSI+] Prion Seeds (Propagons) in the Yeast Saccharomyces cerevisiae

(2009) Lee J. Byrne et al.   PLoS One

Function of SSA Subfamily of Hsp70 Within and Across Species Varies Widely in Complementing Saccharomyces cerevisiae Cell Growth and Prion Propagation

(2009) Deepak Sharma et al.   PLoS One

Variant-specific [PSI+] Infection Is Transmitted by Sup35 Polymers within [PSI+] Aggregates with Heterogeneous Protein Composition

(2008) Sviatoslav N. Bagriantsev et al.   MOLECULAR BIOLOGY OF THE CELL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

(2008) Zhiqiang Du et al.   NATURE GENETICS