From Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Region-Specific Sialylation Pattern of Prion Strains Provides Novel Insight into Prion Neurotropism

(2020) Natallia Makarava et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Transmission of tauopathy strains is independent of their isoform composition

(2020) Zhuohao He et al.   Nature Communications

Evidence of distinct α-synuclein strains underlying disease heterogeneity

(2020) Sara A. M. Holec et al.   ACTA NEUROPATHOLOGICA

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

(2020) Natallia Makarava et al.   NEUROBIOLOGY OF DISEASE

Posttranslational modifications define course of prion strain adaptation and disease phenotype

(2020) Natallia Makarava et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatio-temporal distribution of tubulin-binding cofactors and posttranslational modifications of tubulin in the cochlea of mice

(2020) Lukas Juergens et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

(2019) Paul M. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain

(2019) Darshan Sapkota et al.   Cell Reports

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

(2019) Amanda L. Woerman et al.   ACTA NEUROPATHOLOGICA

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases

(2019) Jiaming Zhang et al.   Frontiers in Neuroscience

In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments

(2019) Aurelio J. Dregni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full atomistic model of prion structure and conversion

(2019) Giovanni Spagnolli et al.   PLoS Pathogens

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

(2019) Naomi P. Visanji et al.   Translational Neurodegeneration

α-Synuclein strains target distinct brain regions and cell types

(2019) Angus Lau et al.   NATURE NEUROSCIENCE

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

(2018) Chao Peng et al.   NEUROBIOLOGY OF DISEASE

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Inflammatory response of microglia to prions is controlled by sialylation of PrPSc

(2018) Saurabh Srivastava et al.   Scientific Reports

Prion Strain-Specific Structure and Pathology: A View from the Perspective of Glycobiology

(2018) Ilia Baskakov et al.   Viruses-Basel

Analyses of N-linked glycans of PrPSc revealed predominantly 2,6-linked sialic acid residues

(2017) Elizaveta Katorcha et al.   FEBS Journal

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Limited understanding of the functional diversity of N-linked glycans as a major gap of prion biology

(2017) Ilia V. Baskakov   Prion

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

New Molecular Insight into Mechanism of Evolution of Mammalian Synthetic Prions

(2016) Natallia Makarava et al.   AMERICAN JOURNAL OF PATHOLOGY

Sialylation of Glycosylphosphatidylinositol (GPI) Anchors of Mammalian Prions Is Regulated in a Host-, Tissue-, and Cell-specific Manner

(2016) Elizaveta Katorcha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialylation Controls Prion Fatein Vivo

(2016) Saurabh Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

(2016) James A. Carroll et al.   PLoS Pathogens

Multifaceted Role of Sialylation in Prion Diseases

(2016) Ilia V. Baskakov et al.   Frontiers in Neuroscience

Reversible off and on switching of prion infectivity via removing and reinstalling prion sialylation

(2016) Elizaveta Katorcha et al.   Scientific Reports

Phosphorylation induces distinct alpha-synuclein strain formation

(2016) Meng-Rong Ma et al.   Scientific Reports

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

Post-translational modification of α-synuclein in Parkinson׳s disease

(2015) Paul J. Barrett et al.   BRAIN RESEARCH

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Post-conversion sialylation of prions in lymphoid tissues

(2015) Saurabh Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two alternative pathways for generating transmissible prion disease de novo

(2015) Natallia Makarava et al.   Acta Neuropathologica Communications

Sialylation of the prion protein glycans controls prion replication rate and glycoform ratio

(2015) Elizaveta Katorcha et al.   Scientific Reports

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrPSc Glycoform and Prion Infectivity

(2014) Elizaveta Katorcha et al.   PLoS Pathogens

Atypical and Classical Forms of the Disease-Associated State of the Prion Protein Exhibit Distinct Neuronal Tropism, Deposition Patterns, and Lesion Profiles

(2013) Gabor G. Kovacs et al.   AMERICAN JOURNAL OF PATHOLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

The Evolution of Transmissible Prions: The Role of Deformed Templating

(2013) Natallia Makarava et al.   PLoS Pathogens

Selective Amplification of Classical and Atypical Prions Using Modified Protein Misfolding Cyclic Amplification

(2012) Natallia Makarava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Mechanism for Transmissible Prion Diseases

(2012) N. Makarava et al.   JOURNAL OF NEUROSCIENCE

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

Genesis of tramsmissible protein states via deformed templating

(2012) Natallia Makarava et al.   Prion

Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Genesis of Mammalian Prions: From Non-infectious Amyloid Fibrils to a Transmissible Prion Disease

(2011) Natallia Makarava et al.   PLoS Pathogens

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

The α-Helical C-Terminal Domain of Full-Length Recombinant PrP Converts to an In-Register Parallel β-Sheet Structure in PrP Fibrils: Evidence from Solid State Nuclear Magnetic Resonance

(2010) Robert Tycko et al.   BIOCHEMISTRY

Two Amyloid States of the Prion Protein Display Significantly Different Folding Patterns

(2010) Valeriy G. Ostapchenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Design and construction of diverse mammalian prion strains

(2009) D. W. Colby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE