The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins

Secondary Prevention for Atherosclerotic Cardiovascular Disease

(2020) Salim S. Virani et al.   CIRCULATION

An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins

(2020) Takeshi Hirota et al.   Expert Opinion on Drug Metabolism & Toxicology

Pleiotropic effects of statins via interaction with the lipid bilayer: A combined approach

(2020) Tadas Penkauskas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Statin Toxicity

(2019) Natalie C. Ward et al.   CIRCULATION RESEARCH

Interaction of the cholesterol reducing agent simvastatin with zwitterionic DPPC and charged DPPG phospholipid membranes

(2019) Ediz Sariisik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Evidence for ATP Interaction with Phosphatidylcholine Bilayers

(2019) Alvaro Garcia et al.   LANGMUIR

Parenteral systems for statin delivery: a review

(2019) Shahla Korani et al.   Lipids in Health and Disease

Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

(2019) Armita Mahdavi Gorabi et al.   Journal of Clinical Medicine

Differential effects of simvastatin on membrane organization and dynamics in varying phases

(2019) Subhashree Shubhrasmita Sahu et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components

(2019) Richard Myles Turner et al.   Journal of Clinical Medicine

Statin wars: have we been misled about the evidence? A narrative review

(2018) Maryanne Demasi   BRITISH JOURNAL OF SPORTS MEDICINE

Statins in Peripheral Artery Disease

(2018) Aaron W. Aday et al.   CIRCULATION

An update on efflux and uptake transporters as determinants of statin response

(2018) Karina Cunha e Rocha et al.   Expert Opinion on Drug Metabolism & Toxicology

Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations

(2018) Albert Selva-O’Callaghan et al.   Expert Review of Clinical Immunology

Spatial structure of atorvastatin and its complex with model membrane in solution studied by NMR and theoretical calculations

(2018) L.F. Galiullina et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

(2018) Shi-You Jiang et al.   Nature Communications

Are the Statins promising antifungal agents against invasive candidiasis?

(2018) William Gustavo Lima et al.   BIOMEDICINE & PHARMACOTHERAPY

Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy

(2018) Leisan F. Galiullina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipophilicity estimation of statins as a decisive physicochemical parameter for their hepato-selectivity using reversed-phase thin layer chromatography

(2017) Azza H. Rageh et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cholesterol Biosynthesis: A Mechanistic Overview

(2016) Nuno M. F. S. A. Cerqueira et al.   BIOCHEMISTRY

Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers

(2016) Lorena Redondo-Morata et al.   BIOPHYSICAL JOURNAL

Calculating Partition Coefficients of Small Molecules in Octanol/Water and Cyclohexane/Water

(2016) Caitlin C. Bannan et al.   Journal of Chemical Theory and Computation

Structural studies of pravastatin and simvastatin and their complexes with SDS micelles by NMR spectroscopy

(2016) I.Z. Rakhmatullin et al.   JOURNAL OF MOLECULAR STRUCTURE

Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells

(2016) Jason Tran et al.   PLoS One

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects

(2015) Mei-Ling Ho et al.   International Journal of Nanomedicine

Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

(2015) Mei-Ling Ho et al.   International Journal of Nanomedicine

Permeability of the Blood–Brain Barrier: Molecular Mechanism of Transport of Drugs and Physiologically Important Compounds

(2015) Clifford W. Fong   JOURNAL OF MEMBRANE BIOLOGY

Expanding the Therapeutic Potential of Statins by Means of Nanotechnology Enabled Drug Delivery Systems

(2014) Bilquis Romana et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Statins in therapy: Understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies

(2014) Clifford W. Fong   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature

(2014) D. Casey et al.   Journal of the Royal Society Interface

Statins Alter Lipid Bilayer Properties

(2013) R. Lea Sanford et al.   BIOPHYSICAL JOURNAL

Intolerance to Statins: Mechanisms and Management

(2013) R. Bitzur et al.   DIABETES CARE

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

(2012) Yoshihisa Shitara et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Prediction of the in vivo OATP1B1-mediated drug–drug interaction potential of an investigational drug against a range of statins

(2012) Pradeep Sharma et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation

(2012) Michael J. Bruno et al.   FARADAY DISCUSSIONS

The pleiotropic effects and therapeutic potential of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in malignancies: A comprehensive review

(2012) Orlando Santana et al.   Journal of Cancer Research and Therapeutics

A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography–tandem mass spectrometry (LC-MS/MS)

(2011) Joyce S. Macwan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions

(2011) Anna Koenen et al.   Expert Review of Clinical Pharmacology

The liquid-ordered state comes of age

(2010) Ole G. Mouritsen   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of sodium bicarbonate as a pharmaceutical formulation excipient on the interaction of fluvastatin with membrane phospholipids

(2010) Germain Larocque et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Efflux and uptake transporters as determinants of statin response

(2010) Alice C Rodrigues   Expert Opinion on Drug Metabolism & Toxicology

Electrostatics in proteins and protein–ligand complexes

(2010) Predrag Kukić et al.   Future Medicinal Chemistry

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

Effect of Gemfibrozil and Fenofibrate on the Pharmacokinetics of Atorvastatin

(2010) Lloyd R. Whitfield et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation

(2010) Xiaoxia Li et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

A historical perspective on the discovery of statins

(2010) Akira ENDO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells

(2009) Alice Cristina Rodrigues et al.   ACTA PHARMACOLOGICA SINICA

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Biotechnological production and applications of statins

(2009) Javier Barrios-González et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modeling Kinetics of Subcellular Disposition of Chemicals

(2009) Stefan Balaz   CHEMICAL REVIEWS

Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

(2009) Michael J. Knauer et al.   CIRCULATION RESEARCH

ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin

(2009) J E Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells

(2009) Daisuke Yamasaki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro

(2008) Ine Blankenberg Skottheim et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

DFT study on hydroxy acid–lactone interconversion of statins: the case of atorvastatin

(2008) Marcin Hoffmann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

(2007) William K.C. Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS