Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration
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Title
Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 24, Pages 9686
Publisher
MDPI AG
Online
2020-12-19
DOI
10.3390/ijms21249686
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Note: Only part of the references are listed.- Pig-to-non-human primate heart transplantation: the final step toward clinical xenotransplantation?
- (2020) Bruno Reichart et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs
- (2020) Ke Huang et al. Science Translational Medicine
- Sensitive detection systems for infectious agents in xenotransplantation*
- (2020) Joachim Denner XENOTRANSPLANTATION
- Prevention of infection in xenotransplantation: Designated pathogen‐free swine in the safety equation
- (2020) Jay A. Fishman XENOTRANSPLANTATION
- Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival
- (2020) Joachim Denner et al. Scientific Reports
- Moral uncertainty and the farming of human-pig chimeras
- (2019) Julian Koplin et al. JOURNAL OF MEDICAL ETHICS
- Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons
- (2019) Luise Krüger et al. Viruses-Basel
- Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells
- (2019) Veronica Crisostomo et al. Stem Cell Research & Therapy
- Cardiac tissue engineering: state-of-the-art methods and outlook
- (2019) Anh H. Nguyen et al. Journal of Biological Engineering
- Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges
- (2019) Pawan KC et al. Regenerative Biomaterials
- The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review
- (2019) Soukaina Bahsoun et al. Journal of Translational Medicine
- Preclinical Studies of Stem Cell Therapy for Heart Disease
- (2018) Bryon A. Tompkins et al. CIRCULATION RESEARCH
- Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman PrimatesNovelty and Significance
- (2018) Keyang Zhu et al. CIRCULATION RESEARCH
- Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients with ST-segment Elevation Myocardial Infarction and Left Ventricular Dysfunction: A Multicenter Randomized, Double-Blind and Placebo-Controlled Clinical Trial
- (2018) Francisco Fernández-Avilés et al. CIRCULATION RESEARCH
- Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges
- (2018) Luiza Bagno et al. MOLECULAR THERAPY
- Recent Progress in Stem Cell Modification for Cardiac Regeneration
- (2018) Heiko Lemcke et al. Stem Cells International
- Perspectives on the Optimal Genetically-Engineered pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation
- (2018) David K.C. Cooper et al. TRANSPLANTATION
- A Thin Layer of Decellularized Porcine Myocardium for Cell Delivery
- (2018) Mickey Shah et al. Scientific Reports
- Stem cells as therapy for heart disease: iPSCs, ESCs, CSCs, and skeletal myoblasts
- (2018) Reza Rikhtegar et al. BIOMEDICINE & PHARMACOTHERAPY
- Consistent success in life-supporting porcine cardiac xenotransplantation
- (2018) Matthias Längin et al. NATURE
- Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
- (2017) Min Chul Kim et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration
- (2017) Makoto Natsumeda et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Exogenous miRNA-146a Enhances the Therapeutic Efficacy of Human Mesenchymal Stem Cells by Increasing Vascular Endothelial Growth Factor Secretion in the Ischemia/Reperfusion-Injured Heart
- (2017) Hyang-Hee Seo et al. JOURNAL OF VASCULAR RESEARCH
- Refining strategies to translate genome editing to the clinic
- (2017) Tatjana I Cornu et al. NATURE MEDICINE
- Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
- (2017) Dong Niu et al. SCIENCE
- Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
- (2017) Santiago Roura et al. Stem Cell Research & Therapy
- Intracoronary Administration of Allogeneic Adipose Tissue–Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction
- (2017) Joaquim Bobi et al. Journal of the American Heart Association
- Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise
- (2017) Robin Duelen et al. EBioMedicine
- CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
- (2017) Wuqiang Zhu et al. CIRCULATION RESEARCH
- Can the outcomes of mesenchymal stem cell-based therapy for myocardial infarction be improved? Providing weapons and armour to cells
- (2016) Andrey A. Karpov et al. CELL PROLIFERATION
- Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery
- (2016) Holly E.M. Mewhort et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
- (2016) Yuji Shiba et al. NATURE
- How Active Are Porcine Endogenous Retroviruses (PERVs)?
- (2016) Joachim Denner Viruses-Basel
- Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects
- (2016) Min Cai et al. Scientific Reports
- Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model
- (2016) Guadalupe Gómez-Mauricio et al. Stem Cell Research & Therapy
- Research Advancements in Porcine Derived Mesenchymal Stem Cells
- (2016) Dinesh Bharti et al. Current Stem Cell Research & Therapy
- Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing
- (2016) Carolina Gálvez-Montón et al. Stem Cells Translational Medicine
- Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia‐Inducible Factor 1‐α (HIF1‐α) in an Ovine Model of Acute Myocardial Infarction
- (2016) Anna P. Hnatiuk et al. Journal of the American Heart Association
- Adult Stem Cell Therapy and Heart Failure, 2000 to 2016
- (2016) Patricia K. Nguyen et al. JAMA Cardiology
- Comparative Efficacy of Intracoronary Allogeneic Mesenchymal Stem Cells and Cardiosphere-Derived Cells in Swine with Hibernating MyocardiumNovelty and Significance
- (2015) Brian R. Weil et al. CIRCULATION RESEARCH
- MicroRNA-133a Engineered Mesenchymal Stem Cells Augment Cardiac Function and Cell Survival in the Infarct Heart
- (2015) Duaa Dakhlallah et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy
- (2015) Vasileios Karantalis et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Treatment of diabetes with encapsulated pig islets: an update on current developments
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- Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes
- (2015) Kavitha T. Kuppusamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
- (2015) L. Yang et al. SCIENCE
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- Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens
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- (2015) Jose L. Estrada et al. XENOTRANSPLANTATION
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- Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease
- (2015) Samuel Golpanian et al. Stem Cells Translational Medicine
- A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome
- (2015) Clara Gallina et al. Stem Cells International
- Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation
- (2014) Muhammad M. Mohiuddin et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction
- (2014) Qing Mao et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
- (2014) James J. H. Chong et al. NATURE
- c-kit+ cells minimally contribute cardiomyocytes to the heart
- (2014) Jop H. van Berlo et al. NATURE
- Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
- (2014) Patricia .E de Almeida et al. Nature Communications
- Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel
- (2014) Todd D. Johnson et al. Biomaterials Science
- eNOS Overexpressing Bone Marrow Cells are Safe and Effective in a Porcine Model of Myocardial Regeneration Following Acute Myocardial Infarction
- (2013) Michael R. Ward et al. Cardiovascular Therapeutics
- Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status
- (2013) Hidetaka Hara et al. IMMUNOLOGY
- The Potential Role of Genetically-Modified Pig Mesenchymal Stromal Cells in Xenotransplantation
- (2013) Jiang Li et al. Stem Cell Reviews and Reports
- Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation
- (2013) Andrew J. Lutz et al. XENOTRANSPLANTATION
- MiR-499 induces cardiac differentiation of rat mesenchymal stem cells through wnt/β-catenin signaling pathway
- (2012) Lu-lu Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial: Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance
- (2012) A. R. Chugh et al. CIRCULATION
- Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction
- (2012) Adam R. Williams et al. CIRCULATION
- Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival
- (2012) FENG HUANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy
- (2012) Joshua M. Hare et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Toll-like receptor 4 ablation improves stem cell survival after hypoxic injury
- (2012) Benjamin D. Brewster et al. JOURNAL OF SURGICAL RESEARCH
- Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells
- (2012) Tao-Sheng Li et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
- (2012) Raj R Makkar et al. LANCET
- Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts
- (2012) Christopher G.A. McGregor et al. TRANSPLANTATION
- Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation
- (2012) Jiang Li et al. XENOTRANSPLANTATION
- Current Stem Cell Delivery Methods for Myocardial Repair
- (2012) Calvin C. Sheng et al. Biomed Research International
- Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC
- (2011) Ralf Hass et al. Cell Communication and Signaling
- Right Ventricular Outflow Tract Repair with a Cardiac Biologic Scaffold
- (2011) John M. Wainwright et al. CELLS TISSUES ORGANS
- Novel MicroRNA Prosurvival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation
- (2011) S. Hu et al. CIRCULATION
- Human PD-L1-overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4+CD25hiFoxp3+ Treg cells
- (2011) Q. Ding et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Hypoxia-inducible Vascular Endothelial Growth Factor-engineered Mesenchymal Stem Cells Prevent Myocardial Ischemic Injury
- (2011) Sun Hwa Kim et al. MOLECULAR THERAPY
- Comparative Analysis of Paracrine Factor Expression in Human Adult Mesenchymal Stem Cells Derived from Bone Marrow, Adipose, and Dermal Tissue
- (2011) Sarah Tzu-Feng Hsiao et al. STEM CELLS AND DEVELOPMENT
- Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk
- (2011) Vered Padler-Karavani et al. XENOTRANSPLANTATION
- Long-term follow-up of patients with type 1 diabetes transplanted with neonatal pig islets
- (2010) R. Valdes-Gonzalez et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
- (2010) Maria Mirotsou et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells
- (2010) C. C. LIN et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- TLR4 Inhibits Mesenchymal Stem Cell (MSC) STAT3 Activation and Thereby Exerts Deleterious Effects on MSC–Mediated Cardioprotection
- (2010) Yue Wang et al. PLoS One
- Combined Therapy With Simvastatin and Bone Marrow–Derived Mesenchymal Stem Cells Increases Benefits in Infarcted Swine Hearts
- (2009) Yue-Jin Yang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
- (2009) Jianhua Zhang et al. CIRCULATION RESEARCH
- Skeletal myoblast sheet transplantation improves the diastolic function of a pressure-overloaded right heart
- (2009) Takaya Hoashi et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity
- (2009) H. C. Quevedo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients
- (2009) Mohamed Ezzelarab et al. TRANSPLANTATION
- Suppression of Human T-Cell Activation and Expansion of Regulatory T Cells by Pig Cells Overexpressing PD-Ligands
- (2009) Annegret Plege et al. TRANSPLANTATION
- Production and characterization of transgenic pigs expressing porcine CTLA4-Ig
- (2009) Carol J. Phelps et al. XENOTRANSPLANTATION
- Local Activation or Implantation of Cardiac Progenitor Cells Rescues Scarred Infarcted Myocardium Improving Cardiac Function
- (2008) Marcello Rota et al. CIRCULATION RESEARCH
- HLA-haplotype banking and iPS cells
- (2008) Norio Nakatsuji et al. NATURE BIOTECHNOLOGY
- In vitroinvestigation of pig cells for resistance to human antibody-mediated rejection
- (2008) Hidetaka Hara et al. TRANSPLANT INTERNATIONAL
- Suppressive Efficacy and Proliferative Capacity of Human Regulatory T Cells in Allogeneic and Xenogeneic Responses
- (2008) Yih-Jyh Lin et al. TRANSPLANTATION
- Intra–Bone Marrow Cotransplantation of Donor Mesenchymal Stem Cells in Pig-to–NOD/SCID Mouse Bone Marrow Transplantation Facilitates Short-Term Xenogeneic Hematopoietic Engraftment
- (2008) H. Eguchi et al. TRANSPLANTATION PROCEEDINGS
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