Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review

NLRP3 Inflammasome and Inflammatory Diseases

(2020) Zheng Wang et al.   Oxidative Medicine and Cellular Longevity

Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia

(2020) Amelia Maria Gaman et al.   REVISTA DE CHIMIE

Toward targeting inflammasomes: insights into their regulation and activation

(2020) Shelbi Christgen et al.   CELL RESEARCH

The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

(2020) Shaima’a Hamarsheh et al.   Nature Communications

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

(2020) Helene Gleitz et al.   BLOOD

Clinical and biological data on the use of hydroxychloroquine against SARS‐CoV‐2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease

(2020) Alessandro Lucchesi et al.   JOURNAL OF MEDICAL VIROLOGY

The Role of Inflammation and Inflammasome in Myeloproliferative Disease

(2020) Lucia Longhitano et al.   Journal of Clinical Medicine

Genetic polymorphisms and expression of NLRP3 inflammasome-related genes are associated with Philadelphia chromosome-negative myeloproliferative neoplasms

(2020) Ying Zhou et al.   HUMAN IMMUNOLOGY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis

(2019) Vinita Yadav et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures

(2019) Waihay J. Wong et al.   PLoS One

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

(2019) Fangfang Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyroptosis: A new frontier in cancer

(2019) Yuan Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

(2018) Maria Kleppe et al.   CANCER CELL

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability

(2018) Nicole Paulin et al.   CIRCULATION

Tissue Factor at the crossroad of coagulation and cell signaling

(2018) Hortensia Zelaya et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of inflammasomes in inflammatory autoimmune rheumatic diseases

(2018) Young-Su Yi   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

(2018) Fiachra Humphries et al.   Nature Communications

NLRP3: A Novel Mediator in Cardiovascular Disease

(2018) Wenyi Zhou et al.   Journal of Immunology Research

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

(2018) Pablo Palazón‐Riquelme et al.   EMBO REPORTS

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

(2018) Jack W. Singer et al.   Oncotarget

Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

(2018) Gunnar Birgegard et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

(2017) Xiao Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammation and myeloproliferative neoplasms

(2017) Federico Lussana et al.   JOURNAL OF AUTOIMMUNITY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

(2017) Hiroshi Nakanishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia

(2017) Neha Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Correlates and Prognostic Significance of IL-8, sIL-2R, and Immunoglobulin-Free Light Chain Levels in Patients with Myelofibrosis

(2017) Maria V. Barabanshikova et al.   Oncology Research and Treatment

Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis

(2017) Marco Romano et al.   OncoImmunology

Coexisting JAK2V617F and CALR Exon 9 Mutations in Myeloproliferative Neoplasms - Do They Designate a New Subtype?

(2016) Rifat Zubair Ahmed et al.   Asian Pacific Journal of Cancer Prevention

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms

(2016) William Vainchenker et al.   BLOOD

Cross Talk Pathways Between Coagulation and Inflammation

(2016) Jonathan H. Foley et al.   CIRCULATION RESEARCH

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

(2016) Jacob Grinfeld et al.   HAEMATOLOGICA

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

(2016) Irina A. Leaf et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

(2016) Jacob Grinfeld et al.   HAEMATOLOGICA

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis

(2015) Fiorella Ciaffoni et al.   BLOOD CELLS MOLECULES AND DISEASES

JAK2V617F,MPL, andCALRMutations in Korean Patients with Essential Thrombocythemia and Primary Myelofibrosis

(2015) Bo Hyun Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development

(2015) Holly L. Geyer et al.   MEDIATORS OF INFLAMMATION

MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

(2015) Hans Carl Hasselbalch et al.   MEDIATORS OF INFLAMMATION

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis

(2015) E. Peelen et al.   MOLECULAR IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

CALRmutations in myeloproliferative neoplasms: Hidden behind the reticulum

(2014) Paola Guglielmelli et al.   AMERICAN JOURNAL OF HEMATOLOGY

Self-oligomerization of ASC PYD Domain Prevents the Assembly of Inflammasome In Vitro

(2014) Kannan Badri Narayanan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

(2014) P. Lundberg et al.   BLOOD

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Localization and Functionality of the Inflammasome in Neutrophils

(2014) Martina Bakele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

(2014) Ying Shao et al.   Journal of Hematology & Oncology

CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons

(2014) A Tefferi et al.   LEUKEMIA

The Thrombotic Events in Polycythemia Vera Patients May Be Related to Increased Oxidative Stress

(2014) Ahmet Durmus et al.   MEDICAL PRINCIPLES AND PRACTICE

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

Myeloproliferative neoplasms and thrombosis

(2013) T. Barbui et al.   BLOOD

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

(2013) E. D. Hottz et al.   BLOOD

The role of cytokines in the initiation and progression of myelofibrosis

(2013) Hans C. Hasselbalch   CYTOKINE & GROWTH FACTOR REVIEWS

AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation

(2013) Weijuan Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mutations and prognosis in primary myelofibrosis

(2013) A M Vannucchi et al.   LEUKEMIA

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

(2013) Thorsten Klampfl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis

(2012) Vibe Skov et al.   EXPERIMENTAL HEMATOLOGY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance

(2012) Vibe Skov et al.   LEUKEMIA RESEARCH

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

TNF  facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

(2011) A. G. Fleischman et al.   BLOOD

New mutations and pathogenesis of myeloproliferative neoplasms

(2011) W. Vainchenker et al.   BLOOD

Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis

(2011) Vibe Skov et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-1  and TGF-  Act Antagonistically in Induction and Differentially in Propagation of Human Proinflammatory Precursor CD4+ T Cells

(2011) K. Hebel et al.   JOURNAL OF IMMUNOLOGY

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Autoimmunity and the risk of myeloproliferative neoplasms

(2010) S. Y. Kristinsson et al.   HAEMATOLOGICA

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F

(2010) M Boissinot et al.   ONCOGENE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

(2009) Damla Olcaydu et al.   NATURE GENETICS

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

(2009) Amy V Jones et al.   NATURE GENETICS

The role of inflammatory cytokines in endothelial dysfunction

(2008) Cuihua Zhang   BASIC RESEARCH IN CARDIOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE