Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?

miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension

(2020) Martin Connolly et al.   PLoS One

Biogenesis and Functions of Circular RNAs Come into Focus

(2020) Mei-Sheng Xiao et al.   TRENDS IN CELL BIOLOGY

miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension

(2020) Li Luo et al.   Aging-US

Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets—From Bench to Bed Site

(2020) Damian Gajecki et al.   Oxidative Medicine and Cellular Longevity

Overexpression of microRNA-340-5p inhibits pulmonary arterial hypertension induced by acute pulmonary embolism by down-regulating Interleukin-1β and Interleukin-6

(2020) Minghui Ou et al.   Molecular Therapy-Nucleic Acids

LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension

(2020) Si Lei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-Mediated Regulation of PDGFRβ

(2020) Christoph M. Zehendner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MiR-18a-5p contributes to enhanced proliferation and migration of PASMCs via targeting Notch2 in pulmonary arterial hypertension

(2020) Renying Miao et al.   LIFE SCIENCES

LincRNA-Cox2 promotes pulmonary arterial hypertension by regulating the let-7a-mediated STAT3 signaling pathway

(2020) Gesheng Cheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CircATP2B4 promotes hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the miR-223/ATR axis

(2020) Junling Guo et al.   LIFE SCIENCES

Right ventricular function in pulmonary (arterial) hypertension

(2019) K. Tello et al.   HERZ

Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment

(2019) Amelia S. Power et al.   PLoS One

Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline

(2019) Zengxian Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Long non‑coding RNA MALAT1 sponges miR‑124‑3p.1/KLF5 to promote pulmonary vascular remodeling and cell cycle progression of pulmonary artery hypertension

(2019) Dapeng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LncRNA-Ang362 Promotes Pulmonary Arterial Hypertension by Regulating miR-221 and miR-222

(2019) Han Wang et al.   SHOCK

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

(2019) Mizuo Ando et al.   Nature Communications

N ɛ -acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

(2019) Fang Wang et al.   Royal Society Open Science

Interactions Between Structural Remodeling and Hypertrophy in the Right Ventricle in Response to Pulmonary Arterial Hypertension

(2019) Reza Avazmohammadi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Circular RNA hsa_circ_0016070 Is Associated with Pulmonary Arterial Hypertension by Promoting PASMC Proliferation

(2019) Sijing Zhou et al.   Molecular Therapy-Nucleic Acids

Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats

(2018) Yanan Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension

(2018) D. Thiwanka Wijeratne et al.  

LncRNA-TCONS_00034812 in cell proliferation and apoptosis of pulmonary artery smooth muscle cells and its mechanism

(2018) Yun Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension

(2018) D. Thiwanka Wijeratne et al.   Circulation-Cardiovascular Quality and Outcomes

Health-Related Quality of Life in Pulmonary Hypertension and Its Clinical Correlates: A Cross-Sectional Study

(2018) Abílio Reis et al.   Biomed Research International

4929Contribution of miR-199b to right ventricular remodelling due to pressure overload

(2018) A M C Koop et al.   EUROPEAN HEART JOURNAL

Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles

(2018) Eric K. Johnson et al.   Scientific Reports

Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members

(2018) Rui Zhang et al.   Scientific Reports

Circulating MicroRNA Markers for Pulmonary Hypertension in Supervised Exercise Intervention and Nightly Oxygen Intervention

(2018) Gabriele Grunig et al.   Frontiers in Physiology

Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy

(2018) Patrick M. Cowley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension

(2018) Birger Tielemans et al.   DRUG DISCOVERY TODAY

Genetics and genomics of pulmonary arterial hypertension

(2018) Nicholas W. Morrell et al.   EUROPEAN RESPIRATORY JOURNAL

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Intensive care, right ventricular support and lung transplantation in patients with pulmonary hypertension

(2018) Marius M. Hoeper et al.   EUROPEAN RESPIRATORY JOURNAL

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

(2017) Wolfgang Poller et al.   EUROPEAN HEART JOURNAL

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model

(2017) Marius M. Hoeper et al.   EUROPEAN RESPIRATORY JOURNAL

Circular RNA – New member of noncoding RNA with novel functions

(2017) Kuei-Yang Hsiao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The role of cardiac energy metabolism in cardiac hypertrophy and failure

(2017) Tomi Tuomainen et al.   EXPERIMENTAL CELL RESEARCH

Long noncoding RNAs in osteoarthritis

(2017) Shi-de Jiang et al.   JOINT BONE SPINE

LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats

(2017) Tian-Tian Zhu et al.   LIFE SCIENCES

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

(2016) Sachindra Raj Joshi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

World Health Organization Group I Pulmonary Hypertension

(2016) Kurt W. Prins et al.   CARDIOLOGY CLINICS

The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy

(2016) Lantao Liu et al.   CARDIOVASCULAR RESEARCH

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2016) Fabrice Antigny et al.   CIRCULATION

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension

(2016) Feng Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

On the origin and evolutionary consequences of gene body DNA methylation

(2016) Adam J. Bewick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis

(2016) Jonathan D W Evans et al.   Lancet Respiratory Medicine

Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

(2016) Ioannis Grammatikakis et al.   Aging-US

MicroRNAs in Pulmonary Arterial Hypertension

(2015) Guofei Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

Molecular Mechanisms of Right Ventricular Failure

(2015) Sushma Reddy et al.   CIRCULATION

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

(2015) D. Chen et al.   HYPERTENSION

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension

(2015) Todd M. Kolb et al.   MICROCIRCULATION

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs

(2015) Ashish Dhir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long non-coding RNA and chromatin remodeling

(2015) Pei Han et al.   RNA Biology

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs

(2015) Ashish Dhir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Right Ventricular Long Noncoding RNA Expression in Human Heart Failure

(2015) Thomas G. Di Salvo et al.   Pulmonary Circulation

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

(2015) Nam Ho Jeoung   Diabetes & Metabolism Journal

Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration

(2014) Margherita Galletti et al.   BIOCHEMICAL PHARMACOLOGY

The economic burden of pulmonary arterial hypertension (PAH) in the US on payers and patients

(2014) Mirko Sikirica et al.   BMC HEALTH SERVICES RESEARCH

Clinical Diagnosis of Pulmonary Hypertension

(2014) Jonathan D. Rich et al.   CIRCULATION

Role of Endothelial Nitric Oxide Synthase and Collagen Metabolism in Right Ventricular Remodeling due to Pulmonary Hypertension

(2014) Suvd Nergui et al.   CIRCULATION JOURNAL

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Extrauterine growth restriction on pulmonary vascular endothelial dysfunction in adult male rats

(2014) Liyan Zhang et al.   JOURNAL OF HYPERTENSION

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

The functional diversity of protein lysine methylation

(2014) S. Lanouette et al.   Molecular Systems Biology

Early detection of pulmonary arterial hypertension

(2014) Edmund M. T. Lau et al.   Nature Reviews Cardiology

MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells

(2014) Yuyu Yang et al.   NUCLEIC ACIDS RESEARCH

Transcriptional regulatory functions of nuclear long noncoding RNAs

(2014) Keith W. Vance et al.   TRENDS IN GENETICS

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Heart Fields and Cardiac Morphogenesis

(2014) R. G. Kelly et al.   Cold Spring Harbor Perspectives in Medicine

MicroRNAs in Right Ventricular (dys)function (2013 Grover Conference Series)

(2014) Thomas Thum et al.   Pulmonary Circulation

Death in Pulmonary Arterial Hypertension

(2013) Ronald J. Oudiz   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Downregulation of Bone Morphogenetic Protein Receptor Axis During HIV-1 and Cocaine-Mediated Pulmonary Smooth Muscle Hyperplasia

(2013) Pranjali Dalvi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell cycle regulation by long non-coding RNAs

(2013) Masatoshi Kitagawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

(2013) S. B. Rothbart et al.   GENES & DEVELOPMENT

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension

(2013) Tomás Pulido et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells

(2013) Junji Otani et al.   PLoS One

Meta-analysis of randomized controlled trials of bosentan for treatment of pulmonary arterial hypertension

(2013) Young Ho Lee et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Roles of long, non-coding RNA in chromosome-wide transcription regulation: Lessons from two dosage compensation systems

(2012) Sylvain Maenner et al.   BIOCHIMIE

Histone H3 phosphorylation – A versatile chromatin modification for different occasions

(2012) Anna Sawicka et al.   BIOCHIMIE

Hemodynamic Stability After Transitioning Between Endothelin Receptor Antagonists in Patients With Pulmonary Arterial Hypertension

(2012) Benjamin Fox et al.   CANADIAN JOURNAL OF CARDIOLOGY

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism

(2012) Maria A. Cavasin et al.   CIRCULATION RESEARCH

A Role for miR-145 in Pulmonary Arterial Hypertension

(2012) Paola Caruso et al.   CIRCULATION RESEARCH

Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

(2012) Jose Gomez-Arroyo et al.   Circulation-Heart Failure

Histone phosphorylation

(2012) Dorine Rossetto et al.   Epigenetics

MicroRNA 21 Inhibits Left Ventricular Remodeling in the Early Phase of Rat Model with Ischemia-reperfusion Injury by Suppressing Cell Apoptosis

(2012) Yanjun Qin et al.   International Journal of Medical Sciences

Non-coding RNAs in Alzheimer's Disease

(2012) Lin Tan et al.   MOLECULAR NEUROBIOLOGY

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

(2012) Jenni Huusko et al.   MOLECULAR THERAPY

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

Cyclic guanosine monophosphate signalling pathway in pulmonary arterial hypertension

(2012) Chien-nien Chen et al.   VASCULAR PHARMACOLOGY

Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension

(2011) Avi Shimony et al.   AMERICAN JOURNAL OF CARDIOLOGY

Suppression of Histone Deacetylases Worsens Right Ventricular Dysfunction after Pulmonary Artery Banding in Rats

(2011) Harm J. Bogaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long non-coding RNA modifies chromatin

(2011) Alka Saxena et al.   BIOESSAYS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Prolonged overcirculation-induced pulmonary arterial hypertension as a cause of right ventricular failure

(2011) B. Rondelet et al.   EUROPEAN HEART JOURNAL

ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre

(2011) J. Hurdman et al.   EUROPEAN RESPIRATORY JOURNAL

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation

(2011) Andy T. Y. Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

DNA-binding factors shape the mouse methylome at distal regulatory regions

(2011) Michael B. Stadler et al.   NATURE

Long Noncoding RNAs, Chromatin, and Development

(2011) Daniel P. Caley et al.   TheScientificWorldJOURNAL

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiac ventricular chambers are epigenetically distinguishable

(2010) Prabhu Mathiyalagan et al.   CELL CYCLE

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Early inflammatory response during the development of right ventricular heart failure in a rat model

(2010) Maria E. Campian et al.   EUROPEAN JOURNAL OF HEART FAILURE

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II

(2010) Hannah J. Durrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA and Epac synergistically inhibit smooth muscle cell proliferation

(2010) Richard C. Hewer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

(2010) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

(2010) Paula A. da Costa Martins et al.   NATURE CELL BIOLOGY

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

(2009) C. Okada et al.   SCIENCE

Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers ofBMPR2Mutation

(2008) Benjamin Sztrymf et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ambrisentan for the Treatment of Pulmonary Arterial Hypertension

(2008) Nazzareno Galiè et al.   CIRCULATION

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

(2008) M. E. Dinger et al.   GENOME RESEARCH

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Intersection of the RNA Interference and X-Inactivation Pathways

(2008) Y. Ogawa et al.   SCIENCE