Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

AIF depletion provides neuroprotection through a preconditioning effect

(2012) Eva-Maria Öxler et al.   APOPTOSIS

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease

(2012) Cinzia Costa et al.   BRAIN

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Protein Degradation Pathways after Brain Ischemia

(2012) Pengfei Ge et al.   CURRENT DRUG TARGETS

Pathophysiology of acute brain dysfunction

(2012) Christopher G. Hughes et al.   Current Opinion in Critical Care

Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?

(2012) Diogo Martins-Branco et al.   EXPERIMENTAL NEUROLOGY

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Proteogenomics of synaptosomal mitochondrial oxidative stress

(2012) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysfunction of the Ubiquitin Ligase Ube3a May Be Associated with Synaptic Pathophysiology in a Mouse Model of Huntington Disease

(2012) Megha Maheshwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation

(2012) Tim J. Craig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

(2012) Brigitte van Zundert et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Case of Infantile Onset Spinocerebellar Ataxia Type 5

(2012) Francois-Dominique Jacob et al.   JOURNAL OF CHILD NEUROLOGY

Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture

(2012) Natasha Bajic et al.   JOURNAL OF NEURAL TRANSMISSION

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Impaired Short-Term Plasticity in Mossy Fiber Synapses Caused by Mitochondrial Dysfunction of Dentate Granule Cells Is the Earliest Synaptic Deficit in a Mouse Model of Alzheimer's Disease

(2012) S. H. Lee et al.   JOURNAL OF NEUROSCIENCE

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology

(2012) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Survival Motor Neuron Protein in Motor Neurons Determines Synaptic Integrity in Spinal Muscular Atrophy

(2012) T. L. Martinez et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Synaptic Proteome Changes in a DNA Repair Deficient Ercc1 Mouse Model of Accelerated Aging

(2012) Marlene J. Végh et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic Analysis Identifies Dysfunction in Cellular Transport, Energy, and Protein Metabolism in Different Brain Regions of Atypical Frontotemporal Lobar Degeneration

(2012) Daniel Martins-de-Souza et al.   JOURNAL OF PROTEOME RESEARCH

Consolidation and translation regulation

(2012) S. Gal-Ben-Ari et al.   LEARNING & MEMORY

Synaptic and nonsynaptic mitochondria demonstrate a different degree of calcium-induced mitochondrial dysfunction

(2012) Chontida Yarana et al.   LIFE SCIENCES

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

(2012) Austen J. Milnerwood et al.   NEUROBIOLOGY OF DISEASE

Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons

(2012) Wenwen Liu et al.   NEUROLOGICAL RESEARCH

Motorneurons Require Cysteine String Protein-α to Maintain the Readily Releasable Vesicular Pool and Synaptic Vesicle Recycling

(2012) José Luis Rozas et al.   NEURON

Maternal Loss of Ube3a Produces an Excitatory/Inhibitory Imbalance through Neuron Type-Specific Synaptic Defects

(2012) Michael L. Wallace et al.   NEURON

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

(2012) Wendy C. Huang et al.   NEURON

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease

(2012) J. Nithianantharajah et al.   NEUROSCIENCE

Molecular Chaperones and Co-Chaperones in Parkinson Disease

(2012) Hemi Dimant et al.   NEUROSCIENTIST

Mutations in the Gene DNAJC5 Cause Autosomal Dominant Kufs Disease in a Proportion of Cases: Study of the Parry Family and 8 Other Families

(2012) Milen Velinov et al.   PLoS One

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease

(2012) Margaret Chia-Ying Wey et al.   PLoS One

The Role of Activity in Synaptic Degeneration in a Protein Misfolding Disease, Prion Disease

(2012) Matteo Caleo et al.   PLoS One

Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A2and synapse damage

(2012) Clive Bate et al.   Prion

Impairments of Synaptic Plasticity in Aged Animals and in Animal Models of Alzheimer's Disease

(2012) Marta Balietti et al.   REJUVENATION RESEARCH

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Ultrastructure of Synapses in the Mammalian Brain

(2012) K. M. Harris et al.   Cold Spring Harbor Perspectives in Biology

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

(2012) Thomas M. Wishart et al.   PLoS Genetics

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

Genetically encoded proton sensors reveal activity-dependent pH changes in neurons

(2012) Joseph V. Raimondo et al.   Frontiers in Molecular Neuroscience

Cellular Links between Neuronal Activity and Energy Homeostasis

(2012) Pavan K. Shetty et al.   Frontiers in Pharmacology

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of PINK1-Parkin-mediated mitophagy

(2011) Wolfdieter Springer et al.   Autophagy

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans

(2011) Chieh Chang et al.   DEVELOPMENT

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders

(2011) Pravir Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis

(2011) Sabine Koch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

 -III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

(2011) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1

(2011) R. Hourez et al.   JOURNAL OF NEUROSCIENCE

 -Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies

(2011) Y. Lim et al.   JOURNAL OF NEUROSCIENCE

Cellular Functions of Ufd2 and Ufd3 in Proteasomal Protein Degradation Depend on Cdc48 Binding

(2011) S. Bohm et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins

(2011) Lindsay A. Schwarz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann–Pick type C1 mice

(2011) Sarah N.R. Pressey et al.   NEUROBIOLOGY OF DISEASE

Neurochemistry and the non-motor aspects of PD

(2011) I. Ferrer et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B Is Expressed Exclusively in Mature Striated Muscle Cells

(2011) Andrew L. Mammen et al.   PLoS One

The neurodegenerative process in a neurotoxic rat model and in patients with Huntington's disease: Histopathological parallels and differences

(2010) Ivana Gunčová et al.   ACTA HISTOCHEMICA

Morphological and Functional Abnormalities in Mitochondria Associated with Synaptic Degeneration in Prion Disease

(2010) Zuzana Sisková et al.   AMERICAN JOURNAL OF PATHOLOGY

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

(2010) Qian Huang et al.   APOPTOSIS

Presynaptic dysfunction in Huntington's disease

(2010) José L. Rozas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Protein homeostasis and synaptic plasticity

(2010) Iván J Cajigas et al.   EMBO JOURNAL

Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria

(2010) Aiyu Yao et al.   HUMAN MOLECULAR GENETICS

Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration inDrosophila

(2010) Damaris N. Lorenzo et al.   JOURNAL OF CELL BIOLOGY

Loss of  -III Spectrin Leads to Purkinje Cell Dysfunction Recapitulating the Behavior and Neuropathology of Spinocerebellar Ataxia Type 5 in Humans

(2010) E. M. Perkins et al.   JOURNAL OF NEUROSCIENCE

Cysteine String Protein-  Prevents Activity-Dependent Degeneration in GABAergic Synapses

(2010) P. Garcia-Junco-Clemente et al.   JOURNAL OF NEUROSCIENCE

Redox proteomics in aging rat brain: Involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process

(2010) M. Perluigi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chaperoning the SNAREs: a role in preventing neurodegeneration?

(2010) Robert D. Burgoyne et al.   NATURE CELL BIOLOGY

Synaptic Protection in the Brain of WldS Mice Occurs Independently of Age but Is Sensitive to Gene-Dose

(2010) Ann K. Wright et al.   PLoS One

Targeted deletion of  III spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes

(2010) M. C. Stankewich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD and axon degeneration: From the Wlds gene to neurochemistry

(2010) Jing Wang et al.   Cell Adhesion & Migration

Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2)

(2009) Randall C. Wilson et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

(2009) Mei Ding et al.   BIOESSAYS

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation

(2009) Shen-Ting Zhao et al.   BMC NEUROSCIENCE

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development

(2009) Mihye Lee et al.   DEVELOPMENTAL BIOLOGY

Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease

(2009) C. Kielar et al.   HUMAN MOLECULAR GENETICS

Synaptic Changes in the Thalamocortical System of Cathepsin D-Deficient Mice

(2009) Sanna Partanen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Kainic Acid-induced F-344 Rat model of Mesial Temporal Lobe Epilepsy: Gene Expression and Canonical Pathways

(2009) Alok K. Sharma et al.   TOXICOLOGIC PATHOLOGY

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell Interactions

(2009) V. Bennett et al.   Cold Spring Harbor Perspectives in Biology

Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy

(2008) Juliane Ramser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

(2008) Mandana Amiri et al.   Developmental Neurobiology

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches

(2008) Y. Lu et al.   HUMAN MOLECULAR GENETICS

Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

(2008) Jianjun Wang et al.   JOURNAL OF CELL BIOLOGY

Role of Inhibitor of Apoptosis Proteins and Smac/DIABLO in Staurosporine-induced Cerebellar Granule Neurons Death

(2008) P. Maycotte et al.   NEUROCHEMICAL RESEARCH

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

(2008) T. D. Helton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Function of Mitochondria in Presynaptic Development at the Neuromuscular Junction

(2007) Chi Wai Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Axon & dendrite degeneration: Its mechanisms and protective experimental paradigms

(2007) Tatsuro Koike et al.   NEUROCHEMISTRY INTERNATIONAL

Cysteine-String Protein

(2003) Luke H. Chamberlain et al.   JOURNAL OF NEUROCHEMISTRY