Interrelated Mechanism by Which the Methide Quinone Celastrol, Obtained from the Roots of Tripterygium wilfordii, Inhibits Main Protease 3CLpro of COVID-19 and Acts as Superoxide Radical Scavenger

Emodin Scavenging of Superoxide Radical Includes π–π Interaction. X-Ray Crystal Structure, Hydrodynamic Voltammetry and Theoretical Studies

(2020) Miriam Rossi et al.   Antioxidants

Early Short Course Corticosteroids in Hospitalized Patients with COVID-19

(2020) Raef Fadel et al.   CLINICAL INFECTIOUS DISEASES

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Should we try the antiinflammatory natural product, celastrol, for COVID ‐19?

(2020) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Antioxidant Properties of Embelin in Cell Culture. Electrochemistry and Theoretical Mechanism of Scavenging. Potential Scavenging of Superoxide Radical through the Cell Membrane

(2020) Francesco Caruso et al.   Antioxidants

Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway

(2020) Jinyan Zhu et al.   ARCHIVES OF VIROLOGY

Coronavirus breakthrough: dexamethasone is first drug shown to save lives

(2020) Heidi Ledford   NATURE

Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone

(2020) Francesco Caruso et al.   Journal of Infection and Public Health

Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats

(2020) Weiyue Hu et al.   Diabetes & Metabolism Journal

In vitro immunomodulatory activity of celastrol against influenza A virus infection

(2018) Niloofar Khalili et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol

(2018) Jun Zha et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

X-Ray Crystal Structure of Embelin and Its DFT Scavenging of Superoxide Radical

(2017) Francesco Caruso et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics

(2017) Yiqing Zhou et al.   Molecular BioSystems

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

(2016) Farrukh Aqil et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Cambridge Structural Database

(2016) Colin R. Groom et al.   Acta Crystallographica Section B-Structural Science Crystal Engineering and Materials

Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells

(2015) Erik Niemelä et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

(2015) Vanna Sanna et al.   International Journal of Nanomedicine

Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner

(2015) Jin Young Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Crystal structure refinement withSHELXL

(2015) George M. Sheldrick   Acta Crystallographica Section C-Structural Chemistry

Solid self-microemulsifying dispersible tablets of celastrol: Formulation development, charaterization and bioavailability evaluation

(2014) Xiaole Qi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells

(2014) Joy Wolfram et al.   JOURNAL OF MICROENCAPSULATION

Enhancement of Oral Bioavailability of Tripterine Through Lipid Nanospheres: Preparation, Characterization, and Absorption Evaluation

(2014) Xingwang Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

(2014) S Boridy et al.   Cell Death & Disease

Preparation, characterization, and assessment of the antiglioma effects of liposomal celastrol

(2012) Yulun Huang et al.   ANTI-CANCER DRUGS

Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model

(2012) Yongping Li et al.   International Journal of Nanomedicine

Optimized Preparation of Celastrol-Loaded Polymeric Nanomicelles Using Rotatable Central Composite Design and Response Surface Methodology

(2012) Xia Peng et al.   Journal of Biomedical Nanotechnology

Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules

(2011) Haeng Ran Seo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Celastrol Inhibits Tat-Mediated Human Immunodeficiency Virus (HIV) Transcription and Replication

(2011) Vivek Narayan et al.   JOURNAL OF MOLECULAR BIOLOGY

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

(2010) Bin Peng et al.   Molecular Cancer

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

(2009) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

(2008) Amy Trott et al.   MOLECULAR BIOLOGY OF THE CELL

Measurement of oxygen reduction activities via the rotating disc electrode method: From Pt model surfaces to carbon-supported high surface area catalysts

(2007) K.J.J. Mayrhofer et al.   ELECTROCHIMICA ACTA