Fucoidans as Potential Therapeutics for Age-Related Macular Degeneration—Current Evidence from In Vitro Research

Risk factors for progression of age‐related macular degeneration

(2020) Thomas J Heesterbeek et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Antioxidant Potential of Sulfated Polysaccharides from Padina boryana; Protective Effect against Oxidative Stress in In Vitro and In Vivo Zebrafish Model

(2020) Thilina U. Jayawardena et al.   Marine Drugs

Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea

(2020) Olga N. Pozharitskaya et al.   Marine Drugs

Effects of a Newly Developed Enzyme-Assisted Extraction Method on the Biological Activities of Fucoidans in Ocular Cells

(2020) Philipp Dörschmann et al.   Marine Drugs

Protective Effects of Fucoidan Isolated from Celluclast-Assisted Extract of Undaria pinnatifida Sporophylls against AAPH-Induced Oxidative Stress In Vitro and In Vivo Zebrafish Model

(2020) Jae-Young Oh et al.   MOLECULES

Retinal pigment epithelium and age‐related macular degeneration: a review of major disease mechanisms

(2020) Shreya Somasundaran et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Enzyme-Assisted Fucoidan Extraction from Brown Macroalgae Fucus distichus subsp. evanescens and Saccharina latissima

(2020) Thuan Thi Nguyen et al.   Marine Drugs

Fucoidan Isolated from Saccharina japonica Inhibits LPS-Induced Inflammation in Macrophages via Blocking NF-κB, MAPK and JAK-STAT Pathways

(2020) Jing Ye et al.   Marine Drugs

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

(2020) Sven Schnichels et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-Glucosidase More Strongly Than α-Amylase and Amyloglucosidase

(2020) Hui Si Audrey Koh et al.   Frontiers in Pharmacology

Fucoidan from Undaria pinnatifida has anti-diabetic effects by stimulation of glucose uptake and reduction of basal lipolysis in 3 T3-L1 adipocytes

(2019) Sung-Yi Sim et al.   NUTRITION RESEARCH

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

(2019) Kai Kaarniranta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Fucoidans from Five Different Brown Algae on Oxidative Stress and VEGF Interference in Ocular Cells

(2019) Philipp Dörschmann et al.   Marine Drugs

Isolation and purification of fucoidan fraction in Turbinaria ornata from the Maldives; Inflammation inhibitory potential under LPS stimulated conditions in in-vitro and in-vivo models

(2019) Thilina U. Jayawardena et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines

(2019) Bittkau et al.   Marine Drugs

Effects of Sulfated Fucans from Laminaria hyperborea Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight

(2019) Philipp Dörschmann et al.   Marine Drugs

Effects of Crude Fucus distichus Subspecies evanescens Fucoidan Extract on Retinal Pigment Epithelium Cells―Implications for Use in Age-Related Macular Degeneration

(2019) Rohwer et al.   Marine Drugs

Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP

(2019) Sang A. Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

(2019) Catarina Oliveira et al.   CARBOHYDRATE POLYMERS

Fucoidan isolated from Padina commersonii inhibit LPS-induced inflammation in macrophages blocking TLR/NF-κB signal pathway

(2019) K.K. Asanka Sanjeewa et al.   CARBOHYDRATE POLYMERS

Hypolipidemic effects of fucoidan fractions from Saccharina sculpera (Laminariales, Phaeophyceae)

(2019) Dandan Ren et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Is the transformation of fucoidans in human body possible?

(2019) T.I. Imbs et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Size distribution and chain conformation of six different fucoidans using size-exclusion chromatography with multiple detection

(2019) Sandesh Neupane et al.   JOURNAL OF CHROMATOGRAPHY A

The Pharmacokinetics of Fucoidan after Topical Application to Rats

(2019) Olga N. Pozharitskaya et al.   Marine Drugs

Initial evaluation of six different brown algae species as source for crude bioactive fucoidans

(2019) Kaya Saskia Bittkau et al.   Algal Research-Biomass Biofuels and Bioproducts

Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells

(2019) Yue Li et al.   Animals

Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities

(2018) Eric Lahrsen et al.   CARBOHYDRATE POLYMERS

Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy

(2018) Yao Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats

(2018) Olga Pozharitskaya et al.   Marine Drugs

Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models

(2018) Jan Tode et al.   Translational Vision Science & Technology

Absorption Study of Mozuku Fucoidan in Japanese Volunteers

(2018) Kizuku Kadena et al.   Marine Drugs

Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation

(2018) Yu-qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fucoidan inhibits LPS-induced inflammation in vitro and during the acute response in vivo

(2017) Jisang Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines

(2017) Michaela Dithmer et al.   Marine Drugs

Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA)

(2017) Ursula Schmidt-Erfurth et al.   OPHTHALMOLOGICA

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis

(2017) Rupert R A Bourne et al.   Lancet Global Health

Dual and antagonic therapeutic effects of sulfated glycans

(2016) Vitor H. Pomin   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling

(2016) Huanjun Chen et al.   CANCER LETTERS

Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis

(2016) Alexa Klettner   Marine Drugs

RPE necroptosis in response to oxidative stress and in AMD

(2015) Jakub Hanus et al.   AGEING RESEARCH REVIEWS

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca2+-dependent ERK signaling pathway

(2015) XIAOXIA LI et al.   Molecular Medicine Reports

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)

(2014) Ursula Schmidt-Erfurth et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum

(2014) MyoungLae Cho et al.   CARBOHYDRATE POLYMERS

Oxidative Stress Induces Biphasic ERK1/2 Activation in the RPE with Distinct Effects on Cell Survival at Early and Late Activation

(2014) Stefan Koinzer et al.   CURRENT EYE RESEARCH

Barrier properties of cultured retinal pigment epithelium

(2014) Lawrence J. Rizzolo   EXPERIMENTAL EYE RESEARCH

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

Intestinal Absorption of Fucoidan Extracted from the Brown Seaweed, Cladosiphon okamuranus

(2014) Takeaki Nagamine et al.   Marine Drugs

Oxidative stress, polyunsaturated fatty acidsderived oxidation products and bisretinoids as potential inducers of CNS diseases: focus on age-related macular degeneration

(2014) Jerzy Z. Nowak   Pharmacological Reports

Fucoidan Reduces Secretion and Expression of Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium and Reduces Angiogenesis In Vitro

(2014) Michaela Dithmer et al.   PLoS One

Toll-like receptor 3 activation in retinal pigment epithelium cells - Mitogen-activated protein kinase pathways of cell death and vascular endothelial growth factor secretion

(2013) Alexa Klettner et al.   ACTA OPHTHALMOLOGICA

Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types

(2013) William M. Watkins et al.   EXPERIMENTAL EYE RESEARCH

Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor

(2013) Wenzhe Yang et al.   EXPERIMENTAL EYE RESEARCH

In vitro antioxidant activities of sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum

(2013) Ryogo Abu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Seven-Year Outcomes in Ranibizumab-Treated Patients in ANCHOR, MARINA, and HORIZON

(2013) Soraya Rofagha et al.   OPHTHALMOLOGY

Molecular characteristics and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava

(2012) Seung-Hong Lee et al.   CARBOHYDRATE POLYMERS

Targeted deletion of Vegfa in adult mice induces vision loss

(2012) Toshihide Kurihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of age related macular degeneration

(2012) Mark E. Pennesi et al.   MOLECULAR ASPECTS OF MEDICINE

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

(2012) Imran Bhutto et al.   MOLECULAR ASPECTS OF MEDICINE

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

(2012) Joan W. Miller et al.   OPHTHALMOLOGY

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Algal fucoidan: structural and size-dependent bioactivities and their perspectives

(2011) V. K. Morya et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The oil spill in ageing Bruch membrane

(2011) C. A. Curcio et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Oxygen Sensing in Retinal Health and Disease

(2011) Clemens A.K. Lange et al.   OPHTHALMOLOGICA

Porcine Ophthalmology

(2010) Sheldon Middleton   VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE

Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases

(2009) Alexa Klettner et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A

(2008) M. Narazaki et al.   BLOOD

Neovascular Age-Related Macular Degeneration

(2008) Aimee V Chappelow et al.   DRUGS

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

(2007) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES