Erythrocytes as a preferential target of oxidative stress in blood

Genotype‐phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency

(2020) Paola Bianchi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized protein aggregates: Formation and biological effects

(2020) Tilman Grune   FREE RADICAL BIOLOGY AND MEDICINE

Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

(2020) Takujiro Homma et al.   FREE RADICAL RESEARCH

How we manage patients with pyruvate kinase deficiency

(2019) Rachael F. Grace et al.   BRITISH JOURNAL OF HAEMATOLOGY

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

Genotype-phenotype associations in Fanconi anemia: A literature review

(2019) Moisés O. Fiesco-Roa et al.   BLOOD REVIEWS

Updated Worldwide Epidemiology of Inherited Erythrocyte Disorders

(2019) Giuseppe Lippi et al.   ACTA HAEMATOLOGICA

Anemia of Inflammation

(2019) Tomas Ganz   NEW ENGLAND JOURNAL OF MEDICINE

Wdr26 regulates nuclear condensation in developing erythroblasts

(2019) Ru Zhen et al.   BLOOD

Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype

(2019) Takujiro Homma et al.   FREE RADICAL RESEARCH

Hepcidin and Anemia: A Tight Relationship

(2019) Alessia Pagani et al.   Frontiers in Physiology

Linkage of typically cytosolic peroxidases to erythrocyte membrane – A possible mechanism of protection in Hereditary Spherocytosis

(2019) Susana Rocha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis

(2018) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study

(2018) Rachael F. Grace et al.   BLOOD

Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease

(2018) Prashant Warang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress

(2018) Moran Benhar   FREE RADICAL BIOLOGY AND MEDICINE

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Erythropoiesis: insights into pathophysiology and treatments in 2017

(2018) Andrea Zivot et al.   MOLECULAR MEDICINE

Red Blood Cell Enzyme Disorders

(2018) Rachael F. Grace et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Haemochromatosis

(2018) Pierre Brissot et al.   Nature Reviews Disease Primers

SOURCES OF VASCULAR NITRIC OXIDE AND REACTIVE OXYGEN SPECIES AND THEIR REGULATION

(2018) Jesús Tejero et al.   PHYSIOLOGICAL REVIEWS

Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia

(2018) Karen S. Romanello et al.   PLoS One

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis

(2017) Shinya Toyokuni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intravascular hemolysis and the pathophysiology of sickle cell disease

(2017) Gregory J. Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Sickle cell disease

(2017) Russell E Ware et al.   LANCET

Anemia of Inflammation

(2017) Paula G. Fraenkel   MEDICAL CLINICS OF NORTH AMERICA

Sickle Cell Disease

(2017) Frédéric B. Piel et al.   NEW ENGLAND JOURNAL OF MEDICINE

UBE2O remodels the proteome during terminal erythroid differentiation

(2017) Anthony T. Nguyen et al.   SCIENCE

Superoxide Dismutase 2 is dispensable for platelet function

(2017) Trevor P. Fidler et al.   THROMBOSIS AND HAEMOSTASIS

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

(2017) Kaiqi Sun et al.   Scientific Reports

Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis

(2016) Takaya Shirato et al.   ARCHIVES OF TOXICOLOGY

Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease

(2016) M. J. Telen   BLOOD

Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane

(2016) Simone B. Bayer et al.   FREE RADICAL RESEARCH

The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice

(2016) Noriyuki Otsuki et al.   FREE RADICAL RESEARCH

Can hydroxyurea serve as a free radical scavenger and reduce iron overload in β-thalassemia patients?

(2016) Khushnooma Italia et al.   FREE RADICAL RESEARCH

Analysis of protein profiling studies of β-thalassemia/Hb E disease

(2016) Pathrapol Lithanatudom et al.   Proteomics Clinical Applications

Thalassemia 2016: Modern medicine battles an ancient disease

(2015) Deborah Rund   AMERICAN JOURNAL OF HEMATOLOGY

SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes

(2015) Takujiro Homma et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse

(2015) Takujiro Homma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

(2015) K. Sun et al.   BLOOD

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)

(2015) Tigist Kassa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

(2015) Kenrick A. Waite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further acatalasemia mutations in human patients from Hungary with diabetes and microcytic anemia

(2015) Terez Nagy et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Oxidative stress in β-thalassaemia and sickle cell disease

(2015) S. Voskou et al.   Redox Biology

Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis

(2014) Christopher S. Thom et al.   DEVELOPMENTAL CELL

Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants

(2014) Fook-Choe Cheah et al.   FASEB JOURNAL

Proteasome Inhibition Induces Both Antioxidant and Hb F Responses in Sickle Cell DiseaseViathe Nrf2 Pathway

(2014) Vinod Pullarkat et al.   HEMOGLOBIN

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

(2014) Yujin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

In This Issue

(2014)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

(2014) Kenji Watanabe et al.   Biomed Research International

Endothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?

(2014) Miriam M. Cortese-Krott et al.   Redox Biology

Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand Black mice

(2013) Tasuku Konno et al.   FREE RADICAL BIOLOGY AND MEDICINE

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherited catalase deficiency: Is it benign or a factor in various age related disorders?

(2013) László Góth et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi Anemia cells

(2013) U Kumari et al.   ONCOGENE

Oxidative Stress andβ-Thalassemic Erythroid Cells behind the Molecular Defect

(2013) Lucia De Franceschi et al.   Oxidative Medicine and Cellular Longevity

2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: Altered proteostasis and oxidative stress

(2013) Avik Basu et al.   PROTEOMICS

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease

(2012) Peter A. Hecker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemoglobin Redox Reactions and Red Blood Cell Aging

(2012) Joseph M. Rifkind et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability

(2012) Ying-Hao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The proteasome: molecular machinery and pathophysiological roles

(2012) Keiji Tanaka et al.   BIOLOGICAL CHEMISTRY

Integrated protein quality-control pathways regulate free  -globin in murine  -thalassemia

(2012) E. Khandros et al.   BLOOD

Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

(2012) Ying-Hao Han et al.   BMB Reports

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation

(2012) Joy G. Mohanty et al.   EXPERIMENTAL HEMATOLOGY

Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency

(2012) Daisaku Yoshihara et al.   FREE RADICAL RESEARCH

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in  -thalassemic erythropoiesis

(2011) L. De Franceschi et al.   HAEMATOLOGICA

Role of oxidative stress in the pathogenesis of sickle cell disease

(2011) Erica N. Chirico et al.   IUBMB LIFE

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified AnimalsGuest Editor: Junichi Fujii Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice

(2011) Junichi Fujii et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Erythrocyte Copper Chaperone for Superoxide Dismutase Is Increased following Marginal Copper Deficiency in Adult and Postweanling Mice

(2011) Katie C. Lassi et al.   JOURNAL OF NUTRITION

Circadian clocks in human red blood cells

(2011) John S. O’Neill et al.   NATURE

SOD2 Deficient Erythroid Cells Up-Regulate Transferrin Receptor and Down-Regulate Mitochondrial Biogenesis and Metabolism

(2011) Florent M. Martin et al.   PLoS One

Irreversible Inactivation of Glutathione Peroxidase 1 and Reversible Inactivation of Peroxiredoxin II by H2O2 in Red Blood Cells

(2010) Chun-Seok Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

(2010) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

Current status of globin gene therapy for the treatment of β-thalassaemia

(2010) Leszek Lisowski et al.   BRITISH JOURNAL OF HAEMATOLOGY

Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients

(2010) Susana Rocha et al.   BRITISH JOURNAL OF HAEMATOLOGY

Peroxiredoxin-2 expression is increased in β-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress

(2010) Alessandro Matte et al.   FREE RADICAL BIOLOGY AND MEDICINE

Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice

(2010) Yoshihito Iuchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis

(2010) Eugene Khandros et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Decreased Erythrocyte CCS Content is a Biomarker of Copper Overload in Rats

(2010) Jesse Bertinato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential regulation of redox proteins and chaperones in HbEβ-thalassemia erythrocyte proteome

(2010) Dipankar Bhattacharya et al.   Proteomics Clinical Applications

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

(2009) Chun-Seok Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase

(2009) Rafał R. Starzyński et al.   BIOCHEMICAL JOURNAL

Rescue of anaemia and autoimmune responses inSOD1-deficient mice by transgenic expression of humanSOD1in erythrocytes

(2009) Yoshihito Iuchi et al.   BIOCHEMICAL JOURNAL

Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice

(2009) Daisaku Yoshihara et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism

(2009) Robert M. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin 2 and Peroxide Metabolism in the Erythrocyte

(2008) Felicia M. Low et al.   ANTIOXIDANTS & REDOX SIGNALING

Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with hereditary spherocytosis

(2008) Susana Rocha et al.   BLOOD CELLS MOLECULES AND DISEASES

The Role of Oxidative Stress in Hemolytic Anemia

(2008) Eitan Fibach et al.   CURRENT MOLECULAR MEDICINE

Irreversible Oxidation of the Active-site Cysteine of Peroxiredoxin to Cysteine Sulfonic Acid for Enhanced Molecular Chaperone Activity

(2008) Jung Chae Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunological methods to quantify and characterize proteasome complexes: Development and application

(2008) Matthias Majetschak et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Extensive Analysis of the Cytoplasmic Proteome of Human Erythrocytes Using the Peptide Ligand Library Technology and Advanced Mass Spectrometry

(2008) Florence Roux-Dalvai et al.   MOLECULAR & CELLULAR PROTEOMICS

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Heat-shock protein-27, -70 and peroxiredoxin–II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model

(2008) Andrea Biondani et al.   Proteomics Clinical Applications

Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes

(2007) Kejing Chen et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY