Epigenomic regulation by labile iron

Iron in infection and immunity

(2020) Manfred Nairz et al.   MOLECULAR ASPECTS OF MEDICINE

A simple and effective dansyl acid based “turn-on” fluorescent probe for detecting labile ferrous iron in physiological saline and live cells

(2020) Guangqin Gao et al.   TALANTA

Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies

(2020) Ning Zhao et al.   JOURNAL OF NUCLEAR MEDICINE

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

(2020) Anna Picca et al.   Cells

Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography

(2019) Ryan K. Muir et al.   ACS Central Science

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

(2019) Toshitaka Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Visualization of Dynamic Changes in Labile Iron(II) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury

(2019) Lijie Wu et al.   ANALYTICAL CHEMISTRY

Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe

(2018) Masato Niwa et al.   ACS Chemical Biology

A coumarin-based fluorescent probe for monitoring labile ferrous iron in living systems

(2018) Lingliang Long et al.   ANALYST

Bioimaging and Biosensing of Ferrous Ion in Neurons and HepG2 Cells upon Oxidative Stress

(2018) Zhichao Liu et al.   ANALYTICAL CHEMISTRY

Calix[4]arene Based Redox Sensitive Molecular Probe for SERS Guided Recognition of Labile Iron Pool in Tumor Cells

(2018) Padincharapad Sreedevi et al.   ANALYTICAL CHEMISTRY

Iron chelation inhibits cancer cell growth and modulates global histone methylation status in colorectal cancer

(2018) Lin-Lin Cao et al.   BIOMETALS

Activity-based sensing fluorescent probes for iron in biological systems

(2018) Allegra T Aron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

(2018) Isaac J. Carney et al.   Metallomics

Toward a Ferrous Iron-Cleavable Linker for Antibody–Drug Conjugates

(2018) Benjamin Spangler et al.   MOLECULAR PHARMACEUTICS

Oxidative stress and aging: the potential role of iron

(2018) Dimitrios Galaris et al.   Hormones-International Journal of Endocrinology and Metabolism

Brain iron loading impairs DNA methylation and alters GABAergic function in mice

(2018) Qi Ye et al.   FASEB JOURNAL

In vivo bioluminescence imaging of labile iron accumulation in a murine model ofAcinetobacter baumanniiinfection

(2017) Allegra T. Aron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

(2017) Tasuku Hirayama et al.   Chemical Science

Engineering Iron Responses in Mammalian Cells by Signal-Induced Protein Proximity

(2017) Guihua Zeng et al.   ACS Synthetic Biology

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

(2017) Vladimir Camarena et al.   eLife

Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development

(2016) Kyle M. Schachtschneider et al.   BMC GENOMICS

Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

(2016) Vincenzo Abbate et al.   CHEMICAL COMMUNICATIONS

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome

(2016) Liron Danielpur et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells

(2016) Allegra T. Aron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Ferrous on Ten-Eleven Translocation Activity and Epigenetic Modifications of Early Mouse Embryos by Fluorescence Microscopy

(2016) Ming-Hui Zhao et al.   MICROSCOPY AND MICROANALYSIS

A reactivity-based probe of the intracellular labile ferrous iron pool

(2016) Benjamin Spangler et al.   Nature Chemical Biology

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

(2016) Ksenija Slavic et al.   Nature Communications

Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems

(2015) Allegra T. Aron et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus

(2015) Phu V. Tran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Regulation of the Epigenome by Vitamin C

(2015) Juan I. Young et al.   Annual Review of Nutrition

Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity

(2015) Vincenzo Abbate et al.   BIOCHEMICAL JOURNAL

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron Regulatory Protein 1 Sustains Mitochondrial Iron Loading and Function in Frataxin Deficiency

(2015) Alain Martelli et al.   Cell Metabolism

A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(iii) pools in C. elegans

(2015) Atul Goel et al.   CHEMICAL COMMUNICATIONS

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

(2015) Tomasa Barrientos et al.   EBioMedicine

White Spot Syndrome Virus Protein Kinase 1 Defeats the Host Cell's Iron-Withholding Defense Mechanism by Interacting with Host Ferritin

(2014) Shin-Jen Lin et al.   JOURNAL OF VIROLOGY

A new class of high-contrast Fe(ii) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin

(2014) Masato Niwa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Special delivery: distributing iron in the cytosol of mammalian cells

(2014) Caroline C. Philpott et al.   Frontiers in Pharmacology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stagePlasmodium falciparum

(2013) Martha Clark et al.   BRITISH JOURNAL OF HAEMATOLOGY

IRP2 Regulates Breast Tumor Growth

(2013) Wei Wang et al.   CANCER RESEARCH

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents

(2013) IGOR P. POGRIBNY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-On Fluorescent Probe

(2013) Ho Yu Au-Yeung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism

(2013) Bailin Zhao et al.   NUCLEIC ACIDS RESEARCH

The Discovery of Histone Demethylases

(2013) Y. G. Shi et al.   Cold Spring Harbor Perspectives in Biology

Intracellular iron trafficking: role of cytosolic ligands

(2012) Maya Shvartsman et al.   BIOMETALS

Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties

(2012) A. Campanella et al.   HUMAN MOLECULAR GENETICS

A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells

(2012) Tasuku Hirayama et al.   Chemical Science

Bmp6 Regulates Retinal Iron Homeostasis and Has Altered Expression in Age-Related Macular Degeneration

(2011) Majda Hadziahmetovic et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

(2011) Anjali Nandal et al.   Cell Metabolism

Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa

(2011) Alexey Obolensky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

(2011) Atanu Maiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of nickel toxicity in microorganisms

(2011) Lee Macomber et al.   Metallomics

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex

(2010) Guanhu Bao et al.   Nature Chemical Biology

Iron and reactive oxygen species activity in parkinsonian substantia nigra

(2010) Anna Wypijewska et al.   PARKINSONISM & RELATED DISORDERS

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

(2010) Li Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferritin binds and activates p53 under oxidative stress

(2009) Jong-Hyuk Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease

(2009) Deepinder Kaur et al.   BRAIN RESEARCH

Ferritin Heavy Chain–Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition

(2009) Ke-Hua Zhang et al.   CANCER RESEARCH

Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

(2009) Jau Yi Li et al.   DEVELOPMENTAL CELL

The Role of Labile Iron in Kidney Disease and Treatment with Chelation

(2009) Sudhir V. Shah et al.   HEMOGLOBIN

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: Implications for Parkinson's disease

(2008) Deepinder Kaur et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the Lysosome: Fluorescent Iron(III) Chelators To Selectively Monitor Endosomal/Lysosomal Labile Iron Pools

(2008) Sarah Fakih et al.   JOURNAL OF MEDICINAL CHEMISTRY

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

Macrophages function as a ferritin iron source for cultured human erythroid precursors

(2007) Moshe J. Leimberg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY