Article
Chemistry, Applied
Marina Pereira-Coelho, Isabel Cristina da Silva Haas, Cassia Katrin Reinke, Jocinei Dognini, Renata Dias de Mello Castanho Amboni, Luciano Vitali, Luiz Augusto dos Santos Madureira
Summary: A simple sample preparation approach employing the dispersive pipette extraction (DPX) technique is proposed to determine twelve polyphenols in wines. The extraction parameters were optimized using univariate and multivariate designs. The analytical performance was satisfactory with high determination coefficients and good precision.
Article
Chemistry, Multidisciplinary
Serkan Topal, Miray Oner, Buse Tugba Zaman, Cansu Demir, Fatma Turak, oemer Tahir Gunkara, Sezgin Bakirdere
Summary: An easy and rapid derivatization and preconcentration method called vortex assisted dispersive liquid-liquid microextraction (VA-DLLME) was proposed for the determination of selenium in lake water samples. The gas chromatography-mass spectrometry (GC-MS) system was utilized to determine inorganic selenium through a developed derivatization procedure. The VA-DLLME method enhanced the detection capability of the GC-MS system through preconcentration of the analyte. Under optimized conditions, the VA-DLLME-Se-PDA-FVD-GC-MS method showed a LOD of 2.2 ng mL(-1) and a LOQ of 7.3 ng mL(-1). Spiking experiments with lake water confirmed the accuracy and applicability of the method with a percent recovery range of 80-106%.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Food Science & Technology
Ainhoa Oller-Ruiz, Natalia Campillo, Manuel Hernandez-Cordoba, Javier Gilabert, Pilar Vinas
Summary: The study proposed using DLLME for preconcentration of lipophilic marine toxins in seawater samples. By optimizing the parameters and validating the method through recovery studies, the analysis showed that the water samples were free of the studied toxins.
Article
Biochemical Research Methods
Lorenza Schettino, Alejandro Garcia-Juan, Laura Fernandez-Lozano, Juan L. Benede, Alberto Chisvert
Summary: This study presents an analytical method for the determination of residual acrylamide in cosmetic products. The method involves vortex-assisted reversed-phase dispersive liquid-liquid microextraction (VA-RP-DLLME) using water as extraction solvent, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for detection. The method shows good analytical features, including high linearity, low limits of detection and quantification, and good repeatability. It is effective, simple, and fast, and can easily determine trace levels of acrylamide in cosmetic products, making it useful for quality control purposes.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Mohamed A. Abdelaziz, Fotouh R. Mansour, Neil D. Danielson
Summary: A hydrophobic gadolinium-based magnetic ionic liquid was studied as an extraction solvent in DLLME for the first time, showing higher extraction efficiency than iron or manganese analogues, leading to improved sensitivity and reproducibility of the method, along with a reduced analysis time.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Sofiyatul Akmal Salim, Rashidah Sukor, Mohd Nazri Ismail, Jinap Selamat
Summary: A method for simultaneous detection of multiple mycotoxins in rice bran was developed and successfully applied to analyze 24 samples. The use of dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry enabled efficient extraction and detection of mycotoxins.
Article
Chemistry, Applied
Hassan Sereshti, Ghazaleh Abdolhosseini, Sara Soltani, Hamed Sadatfaraji, Sajad Karami, Hamid Rashidi Nodeh
Summary: A green dispersive liquid-liquid microextraction method based on a ternary polymeric hydrophobic deep eutectic solvent was developed for monitoring multi-residue pesticides in fruit juices. The method showed low limits of quantification, high linear ranges, and good extraction recoveries under optimized conditions. The effect of different parameters on the extraction efficiency was evaluated and the optimal conditions were determined.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Food Science & Technology
Yi Yang, Shuo Yin, Ling Wu, Yongxin Li, Chengjun Sun
Summary: A novel ionic liquid-based air-assisted dispersive liquid-liquid microextraction combined with high-performance liquid chromatographic method was developed for the simultaneous analysis of six tetracyclines in honey. The method showed good linearities, sensitivity, accuracy, and is convenient for use in the determination of tetracyclines in honey.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Reyla A. S. Dias, Eliane R. Sousa, Gilmar S. Silva, Lanna K. Silva, Arlan S. Freitas, Diana L. D. Lima, Erika M. L. Sousa
Summary: This study developed an HPLC-FLD methodology for the separation of fluoroquinolones and optimized the DLLME process for clean-up and preconcentration of enrofloxacin in water samples. The method showed successful results in samples with low salinity content.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Valfredo Azevedo Lemos, Jeferson Alves Barreto, Luana Bastos Santos, Rosivan dos Santos de Assis, Cleber Galvao Novaes, Ricardo J. Cassella
Summary: Dispersive liquid-liquid microextraction (DLLME) is widely used for the separation and preconcentration of various chemical species, with some systems using a syringe as an extraction environment. This review discusses methods utilizing this approach, critical aspects like dispersion promotion, analytical characteristics, and the pros and cons of the methods, as well as future trends in in-syringe microextraction systems.
Article
Chemistry, Analytical
Maria Consolacion Rodriguez-Palazon, Natalia Arroyo-Manzanares, Pilar Vinas, Natalia Campillo
Summary: This paper presents a new analytical method using DLLME and UHPLC-HRMS for the determination of capsaicin in human urine. The method showed low detection limits and good repeatability, and was successfully applied to the analysis of urine from patients treated with capsaicin-based drugs.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Ainhoa Oller-Ruiz, Pilar Vinas, Manuel Hernandez-Cordoba, Jose Fenoll, Isabel Garrido, Natalia Campillo
Summary: This study determined fifteen aroma compounds in grapes, including their free and glycosylated forms, using dispersive liquid-liquid microextraction with gas chromatography-mass spectrometry. The method involved solid-liquid extraction followed by parallel microextraction for preconcentration. Enzymatic hydrolysis was required for the extraction of bound forms. The method showed good accuracy and precision, with recoveries in the 82-115% range and low relative standard deviations. The analysis revealed the concentrations of several aroma compounds in grapes.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Applied
Yue-Hong Pang, Zhi-Yang Lv, Ji-Cheng Sun, Cheng Yang, Xiao-Fang Shen
Summary: The study developed a method for trace determination of tetracyclines in honey using MOFs for d-SPE. By compounding MIL-101 (Cr), MIL-100 (Fe) and MIL-53 (Al) at a ratio of 7:1:2, effective adsorption-extraction was achieved.
Article
Chemistry, Analytical
Alina Kalyniukova, Ivana Tomaskova, Vitezslava Peskova, Filip Pastierovic, Michal Samek, Jozsef Balogh
Summary: A novel dispersive liquid-liquid microextraction procedure combined with high-performance liquid chromatography and photodiode array detection was developed for the determination of ergosterol. The method showed linear calibration plot, with good recoveries and stability, suitable for the analysis of ergosterol in Norway spruce roots and various fungi samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Muzaffar Iqbal, Essam Ezzeldin, Nazrul Haq, Prawez Alam
Summary: A novel UPLC-MS/MS assay utilizing dispersive liquid-liquid microextraction and ultrasound-assisted reverse extraction has been developed for determination of multiclass pharmaceuticals in water samples. The method showed specificity and reliability for trace analysis of target analytes in waste water samples.
Article
Environmental Sciences
Rosa Penalver, Alberto Ortiz, Natalia Arroyo-Manzanares, Natalia Campillo, Ignacio Lopez-Garcia, Pilar Vinas
Summary: A method for analyzing organic pollutants in seawater using DLLME and GC-MS was proposed, successfully detecting and identifying 18 pollutants, with validation of the method's accuracy using a standard mixture.
Article
Environmental Sciences
Rosa Penalver, Cristina Marin, Natalia Arroyo-Manzanares, Natalia Campillo, Pilar Vinas
Summary: The environment is threatened by increasing plastic residue, and plastic recycling is an interesting solution. A new method using SHS-GC-MS was developed to measure the volatile organic profile of virgin and recycled PET samples. The study identified common compounds in recycled PET samples and proposed a statistical model to quantify the recycled plastic content in PET samples for the first time.
Article
Biochemical Research Methods
Marta Pastor-Belda, Natalia Arroyo-Manzanares, Natalia Campillo, Pilar Vinas, Crystal Guluarte, Carlos Angulo, Maria Angeles Esteban
Summary: This study used ultra-high-performance liquid chromatography with mass spectrometry to identify bioactive compounds from different yeast species. The results showed that these yeasts are a good source of nucleobases, nucleosides, and nucleotides, which have potential as immunostimulants for food additives.
Article
Chemistry, Analytical
Ana Castell, Natalia Arroyo-Manzanares, Juan de Dios Hernandez, Isidro Guillen, Pascuali Vizcaino, Ignacio Lopez-Garcia, Manuel Hernandez-Cordoba, Pilar Vinas
Summary: Headspace gas chromatography coupled to ion mobility spectrometry (HS-GC-IMS) was proposed as an alternative method for detecting and quantifying microbial contamination in pomegranate juice, showing promising results in volatile organic compounds monitoring.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Maria Consolacion Rodriguez-Palazon, Natalia Arroyo-Manzanares, Pilar Vinas, Natalia Campillo
Summary: This paper presents a new analytical method using DLLME and UHPLC-HRMS for the determination of capsaicin in human urine. The method showed low detection limits and good repeatability, and was successfully applied to the analysis of urine from patients treated with capsaicin-based drugs.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
Rosa Penalver, Felix Zapata, Natalia Arroyo-Manzanares, Ignacio Lopez-Garcia, Pilar Vinas
Summary: A reliable and quick strategy for discriminating between recycled and virgin PET water bottles was developed using Raman spectroscopy combined with chemometrics. Chemometric models were created to classify PET samples and determine the level of recycled material in PET bottles.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Biochemical Research Methods
Maria Consolacion Rodriguez-Palazon, Natalia Arroyo-Manzanares, Pilar Vinas, Ignacio Lopez-Garcia, Manuel Hernandez-Cordoba, Natalia Campillo
Summary: A new analytical method combining dispersive magnetic solid-phase extraction (DMSPE) and ultra-high-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF-MS) was developed for the preconcentration and analysis of capsaicin (CAP), dihydrocapsaicin (DCAP), and N-vanillylnonanamide (PCAP) in human serum samples. The use of magnetic multiwalled carbon nanotubes as the adsorbent material yielded the best results. The method was validated by achieving good linearity and low detection limits, and it was also applied for the identification of capsaicinoid metabolites and related compounds in the serum samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Isabel Costa-Gomez, Mariel Suarez-Suarez, Jose Maria Moreno, Stella Moreno-Grau, L. Negral, Natalia Arroyo-Manzanares, Ignacio Lopez-Garcia, Rosa Penalver
Summary: This study aimed to quantify the concentrations of polystyrene microplastics in the smaller fractions, thoracic (PM10) and alveolar (PM2.5) in the air. The majority of polystyrene microplastics were found in the PM2.5 fraction, which is associated with severe cardiopulmonary and respiratory diseases. The main sources of these microplastics could be related to local agricultural practices.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Ana Castell, Natalia Arroyo-Manzanares, Yolanda Guerrero-Nunez, Natalia Campillo, Pilar Vinas
Summary: The botanical origin of honey significantly affects its composition and properties. This study used headspace gas chromatography coupled with mass spectrometry to characterize honey samples from 11 different botanical origins in Spain. The analysis identified 27 volatile compounds, and the samples were classified into five categories based on their botanical origins. The proposed methodology achieved accurate classification of honey samples and could be helpful in determining the authenticity of honey.
Article
Food Science & Technology
Maria Garcia-Nicolas, Natalia Arroyo-Manzanares, Pilar Vinas
Summary: Dispersive magnetic solid-phase extraction (DMSPE) technique combined with high-resolution mass spectrometry and liquid chromatography analysis can be used for sensitive and effective sample treatment of aflatoxins in paprika samples.
Article
Food Science & Technology
Maria Garcia-Nicolas, Marta Pastor-Belda, Natalia Campillo, Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Paloma Abad, Jose Manuel de la Torre, Enrique Guillamon, Alberto Banos, Julio Galvez, Pilar Vinas, Natalia Arroyo-Manzanares
Summary: The present study developed an analytical platform using GC-MS and UHPLC-Q-TOF-MS to analyze the metabolic pathway of PTSO from onion. Two different sample treatments, LLE and SALLE, were used for GC-MS and UHPLC-Q-TOF-MS analysis respectively. An in vivo study was conducted and revealed the presence of DPDS in liver and plasma samples, with highest concentration observed at 0.5 h after ingestion in liver and concentrations between 2.1 and 2.4 μg mL(-1) in plasma. PTSO was only found in plasma at times above 5 h and both PTSO and DPDS were excreted via urine 24 h after ingestion.
Article
Chemistry, Analytical
Maria Garcia-Nicolas, Maria Carmen Perez-Alvarez, Fuensanta Abellan-Alfocea, Natalia Arroyo-Manzanares, Natalia Campillo, Blanca del Val-Oliver, Enrique Jimenez-Santos, Jose Zarauz-Garcia, Luis Saenz, Pilar Vinas
Summary: Inflammatory bowel disease (IBD) is an immune-mediated disease characterized by chronic mucosal inflammation of the digestive tract. This study presents a rapid and reliable diagnostic complementary test for patients with IBD by monitoring the volatile compound fingerprint of serum and urine. The method allows the differentiation between healthy and IBD patients and between different IBD status (remission or active) using integrated markers present in the samples.
Article
Chemistry, Analytical
Lixy Leon-Moran, Marta Pastor-Belda, Natalia Campillo, Natalia Arroyo-Manzanares, Carmen Torres, Pilar Vinas
Summary: This study aimed to develop a novel analytical method for the determination of metabolites of persistent organic pollutants in human tissues. The method achieved good precision and demonstrated no detection of the target compounds in the studied samples.
JOURNAL OF SEPARATION SCIENCE
(2023)
Review
Chemistry, Analytical
Natividad Jurado-Campos, Rocio Rodriguez-Gomez, Natalia Arroyo-Manzanares, Lourdes Arce
Summary: This review explores alternative techniques for classifying olive oils, complementing the current official methods, and provides a detailed description of their advantages and disadvantages. These new techniques can replace or supplement the conventional physicochemical analysis and sensory tasting methods.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Natalia Arroyo-Manzanares, Maria Garcia-Nicolas, Francisco Zafra-Navarro, Natalia Campillo, Pilar Vinas
Summary: Characterization of the botanical origin of honey was carried out using HS-GC-IMS. A chemometric model was established for the classification of honeys with unknown botanical origin.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.