Identification of two subtilisin‐like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana

Peptide signaling for drought-induced tomato flower drop

(2020) S. Reichardt et al.   SCIENCE

Extracellular proteolytic cascade in tomato activates immune protease Rcr3

(2020) Judith K. Paulus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avoiding Proteolysis during the Extraction and Purification of Active Plant Enzymes

(2019) William C Plaxton   PLANT AND CELL PHYSIOLOGY

Genome and transcriptome characterization of the glycoengineered Nicotiana benthamiana line ΔXT/FT

(2019) Matteo Schiavinato et al.   BMC GENOMICS

Steric Accessibility of the Cleavage Sites Dictates the Proteolytic Vulnerability of the Anti‐HIV‐1 Antibodies 2F5, 2G12, and PG9 in Plants

(2019) Alejandro A. Puchol Tarazona et al.   Biotechnology Journal

A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana

(2019) Jiorgos Kourelis et al.   BMC GENOMICS

Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana

(2018) Friederike Grosse-Holz et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant glyco-biotechnology

(2018) Jennifer Schoberer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

(2018) Julia Bally et al.   Annual Review of Phytopathology

The tomato subtilase family includes several cell death-related proteinases with caspase specificity

(2018) Sven Reichardt et al.   Scientific Reports

Exploring Site-Specific N-Glycosylation of HEK293 and Plant-Produced Human IgA Isotypes

(2017) Kathrin Göritzer et al.   JOURNAL OF PROTEOME RESEARCH

From structure to function - a family portrait of plant subtilases

(2017) Andreas Schaller et al.   NEW PHYTOLOGIST

Phytaspase-mediated precursor processing and maturation of the wound hormone systemin

(2017) Roman E. Beloshistov et al.   NEW PHYTOLOGIST

The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire

(2017) Friederike Grosse-Holz et al.   PLANT BIOTECHNOLOGY JOURNAL

The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

(2017) Evelien Moorkens et al.   Frontiers in Pharmacology

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity

(2016) Melanie Paireder et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment

(2016) G. P. Lomonossoff et al.   SCIENCE

Precursor processing for plant peptide hormone maturation by subtilisin-like serine proteinases

(2016) Katharina Schardon et al.   SCIENCE

A non canonical subtilase attenuates the transcriptional activation of defence responses in Arabidopsis thaliana

(2016) Irene Serrano et al.   eLife

Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming

(2016) Manoj K. Mandal et al.   Frontiers in Plant Science

Agroinfiltration contributes to VP1 recombinant protein degradation

(2016) Priyen Pillay et al.   Bioengineered

An Accessory Protease Inhibitor to Increase the Yield and Quality of a Tumour-Targeting mAb in Nicotiana benthamiana Leaves

(2016) Philippe V. Jutras et al.   PLoS One

The increasing value of plant-made proteins

(2015) Markus Sack et al.   CURRENT OPINION IN BIOTECHNOLOGY

Substrate Specificity and Possible Heterologous Targets of Phytaspase, a Plant Cell Death Protease

(2015) Raisa A. Galiullina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycan modulation and sulfoengineering of anti–HIV-1 monoclonal antibody PG9 in plants

(2015) Andreas Loos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification, Characterization and Down-Regulation of Cysteine Protease Genes in Tobacco for Use in Recombinant Protein Production

(2015) Kishor Duwadi et al.   PLoS One

The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: Down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

(2014) Melanie Niemer et al.   Biotechnology Journal

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

(2014) Cawas B. Engineer et al.   NATURE

Proteolytic and N-Glycan Processing of Human  1-Antitrypsin Expressed in Nicotiana benthamiana

(2014) A. Castilho et al.   PLANT PHYSIOLOGY

Proteolysis of recombinant proteins in bioengineered plant cells

(2013) Priyen Pillay et al.   Bioengineered

Antibody degradation in tobacco plants: a predominantly apoplastic process

(2011) Verena K Hehle et al.   BMC BIOTECHNOLOGY

Phytaspase, a relocalisable cell death promoting plant protease with caspase specificity

(2010) Nina V Chichkova et al.   EMBO JOURNAL

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL