The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: Down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycan profiles of the 27 N-glycosylation sites of the HIV envelope protein CN54gp140

(2012) Martin Pabst et al.   BIOLOGICAL CHEMISTRY

Production of different glycosylation variants of the tumour-targeting mAb H10 in Nicotiana benthamiana: influence on expression yield and antibody degradation

(2012) Raffaele Lombardi et al.   TRANSGENIC RESEARCH

Antibody degradation in tobacco plants: a predominantly apoplastic process

(2011) Verena K Hehle et al.   BMC BIOTECHNOLOGY

A protease activity-depleted environment for heterologous proteins migrating towards the leaf cell apoplast

(2011) Charles Goulet et al.   PLANT BIOTECHNOLOGY JOURNAL

Structural basis for the recognition and cleavage of histone H3 by cathepsin L

(2011) Melanie A. Adams-Cioaba et al.   Nature Communications

Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma

(2010) M. Bendandi et al.   ANNALS OF ONCOLOGY

Plant-Produced Trastuzumab Inhibits the Growth of HER2 Positive Cancer Cells

(2010) Brittany M. Grohs et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Production of antibodies in plants: status after twenty years

(2010) Benoit De Muynck et al.   PLANT BIOTECHNOLOGY JOURNAL

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

(2010) R. Pejchal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimisation of the purification process of a tumour-targeting antibody produced in N. benthamiana using vacuum-agroinfiltration

(2010) Raffaele Lombardi et al.   TRANSGENIC RESEARCH

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells

(2009) Benoit De Muynck et al.   TRANSGENIC RESEARCH

Preventing unintended proteolysis in plant protein biofactories

(2008) Meriem Benchabane et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant pharming of a full-sized, tumour-targeting antibody using different expression strategies

(2008) Maria Elena Villani et al.   PLANT BIOTECHNOLOGY JOURNAL

Improvement of recombinant hGM-CSF production by suppression of cysteine proteinase gene expression using RNA interference in a transgenic rice culture

(2008) Nan-Sun Kim et al.   PLANT MOLECULAR BIOLOGY

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission

(2008) K. Ramessar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of peptidases inNicotiana tabacum leaf intercellular fluid

(2008) Mélanie Delannoy et al.   PROTEOMICS