Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV‐infected rhesus macaques

Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after cART interruption in humanized mice

(2019) Lijun Ling et al.   AIDS

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

(2019) Marion Pardons et al.   PLoS Pathogens

Defining early SIV replication and dissemination dynamics following vaginal transmission

(2019) Claire Deleage et al.   Science Advances

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

(2019) Nadine Bachmann et al.   Nature Communications

Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives

(2019) Monica Baiula et al.   Frontiers in Chemistry

Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques

(2019) Peter Abbink et al.   SCIENCE

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

(2019) M. Di Mascio et al.   SCIENCE

Blocking α4β7 integrin binding to SIV does not improve virologic control

(2019) Nami Iwamoto et al.   SCIENCE

An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals

(2019) Michael C. Sneller et al.   Science Translational Medicine

Activation and suppression of haematopoietic integrins in hemostasis and immunity

(2019) Martijn A. Nolte et al.   BLOOD

Blood biomarkers of expressed and inducible HIV-1

(2018) Anthony R. Cillo et al.   AIDS

Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype

(2018) James D. Lord et al.   CLINICAL IMMUNOLOGY

Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8+ Cells

(2018) Benjamin B. Policicchio et al.   JOURNAL OF VIROLOGY

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

(2018) Fatima Nawaz et al.   Mucosal Immunology

Total HIV DNA: a global marker of HIV persistence

(2018) Christine Rouzioux et al.   Retrovirology

What do we measure when we measure cell-associated HIV RNA

(2018) Alexander O. Pasternak et al.   Retrovirology

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes

(2018) Aida Sivro et al.   Science Translational Medicine

Retroviral RNA Dimerization: From Structure to Functions

(2018) Noé Dubois et al.   Frontiers in Microbiology

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

(2018) Afam A. Okoye et al.   NATURE MEDICINE

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

(2018) Sakaorat Lertjuthaporn et al.   PLoS Pathogens

α4β7 integrin inhibitors: a patent review

(2018) Hao Li et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate to Severe Ulcerative Colitis

(2018) William J. Sandborn et al.   GASTROENTEROLOGY

Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption

(2018) Ching-Lan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

(2018) Mathieu Uzzan et al.   Science Translational Medicine

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

(2018) Constantinos Kurt Wibmer et al.   Nature Communications

The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohnʼs Disease Effector T Cells In Vivo

(2017) Sebastian Zundler et al.   INFLAMMATORY BOWEL DISEASES

Integrin α4β7Blockade Preferentially Impacts CCR6+Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

(2017) Giulia Calenda et al.   JOURNAL OF IMMUNOLOGY

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection

(2017) P J Santangelo et al.   Mucosal Immunology

Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin

(2017) Subhash Chand et al.   VIROLOGY

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals

(2016) Amy E. Baxter et al.   Cell Host & Microbe

α4 β1 integrin promotes accumulation of tissue-resident memory CD8+ T cells in salivary glands

(2016) Sandra Woyciechowski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA

(2016) Feiyu Hong et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Development of real-time PCR for quantitation of simian immunodeficiency virus 2-LTR circles

(2016) Michael Lee et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

(2016) Maja Kiselinova et al.   PLoS Pathogens

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

(2016) Géraldine Arrode-Brusés et al.   PLoS Pathogens

Establishment and stability of the latent HIV-1 DNA reservoir

(2016) Johanna Brodin et al.   eLife

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

(2015) Guillaume Martin-Blondel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Minor Contribution of Chimeric Host-HIV Readthrough Transcripts to the Level of HIV Cell-AssociatedgagRNA

(2015) Alexander O. Pasternak et al.   JOURNAL OF VIROLOGY

Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells

(2015) Huanbin Xu et al.   JOURNAL OF VIROLOGY

Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease

(2015) Ioannis Mitroulis et al.   PHARMACOLOGY & THERAPEUTICS

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Quantification of Integrated HIV DNA by Repetitive-Sampling Alu-HIV PCR on the Basis of Poisson Statistics

(2014) W. De Spiegelaere et al.   CLINICAL CHEMISTRY

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

(2014) James B. Whitney et al.   NATURE

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

(2014) Siddappa N Byrareddy et al.   NATURE MEDICINE

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

The Frequency of α4β7high Memory CD4+ T Cells Correlates With Susceptibility to Rectal Simian Immunodeficiency Virus Infection

(2013) Elena Martinelli et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Preferential HIV Infection of CCR6+ Th17 Cells Is Associated with Higher Levels of Virus Receptor Expression and Lack of CCR5 Ligands

(2013) Y. Alvarez et al.   JOURNAL OF VIROLOGY

Cell-associated HIV RNA: a dynamic biomarker of viral persistence

(2013) Alexander O Pasternak et al.   Retrovirology

IL-7 induces expression and activation of integrin  4 7 promoting naive T-cell homing to the intestinal mucosa

(2012) R. Cimbro et al.   BLOOD

IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques

(2012) H Xu et al.   Mucosal Immunology

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV

(2011) Claudia Cicala et al.   Journal of Translational Medicine

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission

(2011) Fatima Nawaz et al.   PLoS Pathogens

Control of α4β7 Integrin Expression and CD4 T Cell Homing by the β1 Integrin Subunit

(2010) Christopher C. DeNucci et al.   JOURNAL OF IMMUNOLOGY

Blocking of  4 7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2010) A. A. Ansari et al.   JOURNAL OF IMMUNOLOGY

Preliminary in vivo efficacy studies of a recombinant rhesus anti-α4β7 monoclonal antibody

(2009) L.E. Pereira et al.   CELLULAR IMMUNOLOGY

Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention

(2009) G. Gorfu et al.   CURRENT MOLECULAR MEDICINE

Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection

(2009) X Wang et al.   Mucosal Immunology

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

(2009) M Kader et al.   Mucosal Immunology

High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections

(2009) Y. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4

(2008) Eduardo Pauls et al.   AIDS

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

A small molecule, orally active, α4β1/α4β7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats

(2006) Julio Cortijo et al.   BRITISH JOURNAL OF PHARMACOLOGY