Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway

Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice

(2019) Ling Chen et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

trans -Resveratrol ameliorates anxiety-like behaviors and fear memory deficits in a rat model of post-traumatic stress disorder

(2018) Gaowen Li et al.   NEUROPHARMACOLOGY

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

(2018) Robert J. Fenster et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

(2018) Ying Xu et al.   Frontiers in Aging Neuroscience

Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling

(2017) John Lisman   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways

(2017) Li Wang et al.   Scientific Reports

The use of the Emotional-Object Recognition as an assay to assess learning and memory associated to an aversive stimulus in rodents

(2016) Anna Brancato et al.   JOURNAL OF NEUROSCIENCE METHODS

Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder

(2015) Aline Desmedt et al.   BIOLOGICAL PSYCHIATRY

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

(2015) Ying Xu et al.   NEUROBIOLOGY OF AGING

The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus–pituitary–adrenal axis

(2015) Cong Pang et al.   NEUROPHARMACOLOGY

Brain sites involved in fear memory reconsolidation and extinction of rodents

(2015) Elisabetta Baldi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

(2014) Lianshu Ding et al.   BEHAVIOURAL BRAIN RESEARCH

The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems

(2014) Chong Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

The relation of infant attachment to attachment and cognitive and behavioural outcomes in early childhood

(2014) Yan-hua Ding et al.   EARLY HUMAN DEVELOPMENT

Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder

(2014) Li-Ming Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats

(2013) L.I. Serova et al.   NEUROSCIENCE

Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway

(2012) Ying Xu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences

(2012) Yingcong Yu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Unconditioned freezing is enhanced in an appetitive context: Implications for the contextual dependency of unconditioned fear

(2012) Dayan Knox et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2012) Annerieke S.R. Sierksma et al.   NEUROPHARMACOLOGY

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway

(2011) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway

(2011) Y. Xu et al.   NEUROSCIENCE

Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

(2010) Ying Xu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

(2009) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS