Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways
Authors
Keywords
-
Journal
Scientific Reports
Volume 7, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-09-15
DOI
10.1038/s41598-017-08070-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition
- (2016) Liang Zhang et al. HUMAN REPRODUCTION
- The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling
- (2016) Gang Wang et al. Oncotarget
- Apoptogenic effects of β-sitosterol glucoside fromCastanopsis indicaleaves
- (2015) Narayan Dolai et al. NATURAL PRODUCT RESEARCH
- Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE1 in mice
- (2015) Alejandro Galindo-Tovar et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors
- (2015) E. Bollen et al. NEUROPHARMACOLOGY
- Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4)
- (2015) Kelle M. Franklin et al. PSYCHOPHARMACOLOGY
- Alzheimer disease, inflammation, and novel inflammatory marker: resistin
- (2015) Muhammet Cemal KIZILARSLANOĞLU et al. Turkish Journal Of Medical Sciences
- Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25–35 peptide-injected mice, a nontransgenic Alzheimer’s disease model
- (2015) Valentine Lahmy et al. Frontiers in Cellular Neuroscience
- Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?
- (2015) Michelle M. Williams et al. Oncotarget
- The Interplay between Cyclic AMP, MAPK, and NF-κB Pathways in Response to Proinflammatory Signals in Microglia
- (2015) Mousumi Ghosh et al. Biomed Research International
- Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms
- (2014) Lianshu Ding et al. BEHAVIOURAL BRAIN RESEARCH
- The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems
- (2014) Chong Zhang et al. CURRENT PHARMACEUTICAL DESIGN
- Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview
- (2014) P.R.A. Heckman et al. CURRENT PHARMACEUTICAL DESIGN
- Role of AKAP 149–PKA–PDE4A complex in cell survival and cell differentiation processes
- (2014) A. Fernández-Araujo et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Combined administration of curcumin and gallic acid inhibits gallic acid-induced suppression of steroidogenesis, sperm output, antioxidant defenses and inflammatory responsive genes
- (2014) Sunny O. Abarikwu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
- (2013) Yen Ying Lim et al. NEUROBIOLOGY OF AGING
- Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice
- (2013) Róisín M. McManus et al. NEUROBIOLOGY OF AGING
- Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats
- (2013) Jun Zhang et al. PLoS One
- The oligopeptide DT-2 is a specific PKG I inhibitor onlyin vitro, not in living cells
- (2012) Stepan Gambaryan et al. BRITISH JOURNAL OF PHARMACOLOGY
- Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway
- (2012) Ying Xu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease
- (2012) Annerieke S.R. Sierksma et al. NEUROPHARMACOLOGY
- Toll-like receptor (TLR) and inflammasome actions in the central nervous system
- (2012) Richa Hanamsagar et al. TRENDS IN IMMUNOLOGY
- IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
- (2011) John S. Tzartos et al. AMERICAN JOURNAL OF PATHOLOGY
- Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics
- (2011) R. Scott Bitner BIOCHEMICAL PHARMACOLOGY
- The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats
- (2011) Chuang Wang et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Active Immunization with Amyloid- 1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System
- (2010) P. Vollmar et al. JOURNAL OF IMMUNOLOGY
- The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups
- (2010) Sang-Bin Baek et al. NEUROSCIENCE LETTERS
- Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats
- (2010) Yu-Fang Cheng et al. PSYCHOPHARMACOLOGY
- ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO
- (2009) Marieke A.D. van Zoelen et al. SHOCK
- The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging
- (2008) K. Domek-Łopacińska et al. BRAIN RESEARCH
- Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice
- (2007) Yves Porte et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started