Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice

Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway

(2017) Idu Azogu et al.   HORMONES AND BEHAVIOR

The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain

(2017) Zhi-Kun Qiu et al.   METABOLIC BRAIN DISEASE

Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways

(2017) Li Wang et al.   Scientific Reports

The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

(2016) Ligia Mendes Soares et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Prevalence of antipsychotic prescriptions among patients with anxiety disorders treated in inpatient and outpatient psychiatric settings

(2016) Samuel R. Weber et al.   JOURNAL OF AFFECTIVE DISORDERS

CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors

(2016) Jing Zhang et al.   Scientific Reports

Generalized Anxiety Disorder

(2015) Murray B. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

(2014) Lianshu Ding et al.   BEHAVIOURAL BRAIN RESEARCH

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

(2013) Gaurav Patki et al.   BRAIN RESEARCH

Enhancement of Behavioral Sensitization, Anxiety-Like Behavior, and Hippocampal and Frontal Cortical CREB Levels Following Cocaine Abstinence in Mice Exposed to Cocaine during Adolescence

(2013) Maria Cristina Valzachi et al.   PLoS One

The distribution of phosphodiesterase 2A in the rat brain

(2012) D.T. Stephenson et al.   NEUROSCIENCE

Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

(2009) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice

(2008) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Estradiol Regulates Corticotropin-Releasing Hormone Gene (crh) Expression in a Rapid and Phasic Manner that Parallels Estrogen Receptor-α and -β Recruitment to a 3′,5′-Cyclic Adenosine 5′-Monophosphate Regulatory Region of the ProximalcrhPromoter

(2007) Avin S. Lalmansingh et al.   ENDOCRINOLOGY