A comprehensive review on potential therapeutics interventions for COVID-19

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

(2020) Tuan M. Nguyen et al.   CELL RESEARCH

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle

(2020) Hongzhou Lu et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

SARS-CoV-2 is an appropriate name for the new coronavirus

(2020) Yuntao Wu et al.   LANCET

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

(2020) Matteo Chinazzi et al.   SCIENCE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks

(2020) Hossam M. Ashour et al.   Pathogens

Airborne transmission of severe acute respiratory syndrome coronavirus‐2 to healthcare workers: a narrative review

(2020) N. M. Wilson et al.   ANAESTHESIA

COVID-19 infection and rheumatoid arthritis: Faraway, so close!

(2020) Ennio Giulio Favalli et al.   AUTOIMMUNITY REVIEWS

Current pharmacological treatments for COVID‐19: What's next?

(2020) Cristina Scavone et al.   BRITISH JOURNAL OF PHARMACOLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019‐nCoV Infection

(2020) Yin‐Xiao Du et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Public Health Approach of Ayurveda and Yoga for COVID-19 Prophylaxis

(2020) Girish Tillu et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Deployment of convalescent plasma for the prevention and treatment of COVID-19

(2020) Evan M. Bloch et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019

(2020) Qing-Lei Zeng et al.   JOURNAL OF INFECTIOUS DISEASES

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial

(2020) Richard O Phillips et al.   LANCET

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

(2020) Irani Thevarajan et al.   NATURE MEDICINE

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

COVID-19: faecal–oral transmission?

(2020) Jordan Hindson   Nature Reviews Gastroenterology & Hepatology

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developing Covid-19 Vaccines at Pandemic Speed

(2020) Nicole Lurie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease

(2020) Rachel M. Golonka et al.   PHYSIOLOGICAL GENOMICS

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

Immunogenicity of a DNA vaccine candidate for COVID-19

(2020) Trevor R. F. Smith et al.   Nature Communications

The hallmarks of COVID-19 disease

(2020) Daolin Tang et al.   PLoS Pathogens

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

(2020) Samuel James Brake et al.   Journal of Clinical Medicine

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

(2020) Qingxian Cai et al.   Engineering

Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease

(2020) Irogue Igbinosa et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19

(2020) Samia Arshad et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Therapeutic potential of ciclesonide inhalation for COVID-19 pneumonia: Report of three cases

(2020) Keisuke Iwabuchi et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply

(2020) Chris De Savi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study

(2020) Ruocong Yang et al.   PHARMACOLOGICAL RESEARCH

Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   RESPIRATORY MEDICINE

The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells

(2020) Shutoku Matsuyama et al.   JOURNAL OF VIROLOGY

Ayurvedic treatment of COVID-19/SARS-CoV-2: A case report

(2020) P.L.T. Girija et al.   Journal of Ayurveda and Integrative Medicine

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux

(2019) Leandro Silva da Costa et al.   Cell Death & Disease

The Molecular Aspect of Antitumor Effects of Protease Inhibitor Nafamostat Mesylate and Its Role in Potential Clinical Applications

(2019) Xi Chen et al.   Frontiers in Oncology

Favipiravir as a potential countermeasure against neglected and emerging RNA viruses

(2018) Leen Delang et al.   ANTIVIRAL RESEARCH

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Baricitinib in rheumatoid arthritis: evidence-to-date and clinical potential

(2017) Bindee Kuriya et al.   Therapeutic Advances in Musculoskeletal Disease

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Baricitinib in Patients with Refractory Rheumatoid Arthritis

(2016) Mark C. Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

(2016) Rameshwar U. Kadam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

(2016) Daouda Sissoko et al.   PLOS MEDICINE

Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report

(2015) Uh Jin Kim et al.   ANTIVIRAL THERAPY

Arbidol as a broad-spectrum antiviral: An update

(2014) Julie Blaising et al.   ANTIVIRAL RESEARCH

Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders

(2014) Rami A. Al-Horani et al.   MEDICINAL RESEARCH REVIEWS

Indian Traditional Ayurvedic System of Medicine and Nutritional Supplementation

(2013) M. M. Pandey et al.   Evidence-based Complementary and Alternative Medicine

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Preadmission Use of Inhaled Corticosteroids Is Associated With a Reduced Risk of Direct Acute Lung Injury/Acute Respiratory Distress Syndrome

(2011) Enrique Ortiz-Diaz et al.   CHEST

Early Use of Glucocorticoids Was a Risk Factor for Critical Disease and Death From pH1N1 Infection

(2011) K. Han et al.   CLINICAL INFECTIOUS DISEASES

Tocilizumab

(2010) Adith Venkiteshwaran   mAbs

Tocilizumab

(2009) Vicki Oldfield et al.   DRUGS