Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults

A novel technique for intraduodenal administration of drug suspensions / solutions with concurrent pH monitoring applied to ibuprofen formulations

(2019) Michael Hofmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates

(2017) Chara Litou et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

(2017) Bart Hens et al.   MOLECULAR PHARMACEUTICS

In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions

(2017) Mark J. Koenigsknecht et al.   MOLECULAR PHARMACEUTICS

FaSSIF-V3, but not compendial media, appropriately detects differences in the peak and extent of exposure between reference and test formulations of ibuprofen

(2016) Rodrigo Cristofoletti et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

(2016) Chara Litou et al.   PHARMACEUTICAL RESEARCH

Characterisation of human saliva as a platform for oral dissolution medium development

(2015) Sally Gittings et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A mathematical model of pH, based on the total stoichiometric concentration of acids, bases and ampholytes dissolved in water

(2015) Roberto Mioni et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Composition and Physicochemical Properties of Fasted‐State Human Duodenal and Jejunal Fluid: A Critical Evaluation of the Available Data

(2014) Alexander Fuchs et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The buffer capacity of airway epithelial secretions

(2014) Dusik Kim et al.   Frontiers in Physiology

Buffer capacity of biologics-from buffer salts to buffering by antibodies

(2013) Anne R. Karow et al.   BIOTECHNOLOGY PROGRESS

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

(2013) Christel A.S. Bergström et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

(2013) Pernille Barbre Pedersen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evolution of a physiological pH6.8 bicarbonate buffer system: Application to the dissolution testing of enteric coated products

(2011) Fang Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Precipitation in and Supersaturation of Contents of the Upper Small Intestine After Administration of Two Weak Bases to Fasted Adults

(2011) Dimitrios Psachoulias et al.   PHARMACEUTICAL RESEARCH

Pancreatic Bicarbonate Secretion Involves Two Proton Pumps

(2010) Ivana Novak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Solubility in Luminal Fluids from Different Regions of the Small and Large Intestine of Humans

(2010) H. M. Fadda et al.   MOLECULAR PHARMACEUTICS

Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?

(2008) John L. Wallace   PHYSIOLOGICAL REVIEWS