C‐Reactive Protein: Marker of risk for post‐traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery

Immune Biomarkers Alterations in Post-traumatic Stress Disorder: A Systematic Review and Meta-analysis

(2020) Juan-Juan Yang et al.   JOURNAL OF AFFECTIVE DISORDERS

Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

(2020) Tammy D. Kim et al.   Antioxidants

Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia

(2020) Mandakh Bekhbat et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women

(2020) Neeti D Mehta et al.   Social Cognitive and Affective Neuroscience

Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways

(2020) Menizibeya O. Welcome et al.   PHARMACOLOGICAL RESEARCH

Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey

(2019) San Lee et al.   Scientific Reports

Neurobiology of Resilience: Interface Between Mind and Body

(2019) Flurin Cathomas et al.   BIOLOGICAL PSYCHIATRY

Inflammation and decreased functional connectivity in a widely-distributed network in depression: Centralized effects in the ventral medial prefrontal cortex

(2019) Lijun Yin et al.   BRAIN BEHAVIOR AND IMMUNITY

Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression

(2019) Roger S. McIntyre et al.   JAMA Psychiatry

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

(2019) Joel Gelernter et al.   NATURE NEUROSCIENCE

Damage-associated molecular patterns in trauma

(2019) Borna Relja et al.   European Journal of Trauma and Emergency Surgery

Inflammation and depressive phenotypes: evidence from medical records from over 12 000 patients and brain morphology

(2019) Maria Ironside et al.   PSYCHOLOGICAL MEDICINE

Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation

(2018) Jessica Deslauriers et al.   BIOLOGICAL PSYCHIATRY

CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein

(2018) M.W. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women

(2018) Jennifer A. Sumner et al.   BRAIN BEHAVIOR AND IMMUNITY

Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β

(2018) Meghan E. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

(2018) Sarah R. Horn et al.   BRAIN BEHAVIOR AND IMMUNITY

A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence?

(2018) K.B. Casaletto et al.   CYTOKINE

Association of Stress-Related Disorders With Subsequent Autoimmune Disease

(2018) Huan Song et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice

(2018) Matthew B. Young et al.   PSYCHONEUROENDOCRINOLOGY

Aggression, Social Stress, and the Immune System in Humans and Animal Models

(2018) Aki Takahashi et al.   Frontiers in Behavioral Neuroscience

Role of C-Reactive Protein at Sites of Inflammation and Infection

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes

(2018) James D. McFadyen et al.   Frontiers in Immunology

Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results

(2018) Neeti D. Mehta et al.   BRAIN BEHAVIOR AND IMMUNITY

Relations of combat stress and posttraumatic stress disorder to 24-hour plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity

(2018) Agorastos Agorastos et al.   PSYCHONEUROENDOCRINOLOGY

Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia

(2018) Ebrahim Haroon et al.   Translational Psychiatry

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks

(2017) Rebecca L. Rosen et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

(2017) D B McKim et al.   MOLECULAR PSYCHIATRY

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma

(2017) Michael S Breen et al.   NEUROPSYCHOPHARMACOLOGY

On the transdiagnostic nature of peripheral biomarkers in major psychiatric disorders: A systematic review

(2017) Jairo Vinícius Pinto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Resilience to traumatic events related to urban violence and increased IL10 serum levels

(2017) Stefania P. Teche et al.   PSYCHIATRY RESEARCH

Complement in the pathogenesis of Alzheimer’s disease

(2017) B. Paul Morgan   Seminars in Immunopathology

Deconvolution of Transcriptional Networks in Post-Traumatic Stress Disorder Uncovers Master Regulators Driving Innate Immune System Function

(2017) Abolfazl Doostparast Torshizi et al.   Scientific Reports

Association of Trauma and Posttraumatic Stress Disorder With Incident Systemic Lupus Erythematosus in a Longitudinal Cohort of Women

(2017) Andrea L. Roberts et al.   Arthritis & Rheumatology

Associations of childhood adversity and adulthood trauma with C-reactive protein: A cross-sectional population-based study

(2016) Joy E. Lin et al.   BRAIN BEHAVIOR AND IMMUNITY

Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials

(2016) Michael V Fedewa et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD and Beyond

(2016) Vasiliki Michopoulos et al.   NEUROPSYCHOPHARMACOLOGY

Relationships between anhedonia, alexithymia, impulsivity, suicidal ideation, recent suicide attempt, C-reactive protein and serum lipid levels among 122 inpatients with mood or anxious disorders

(2016) Gwenolé Loas et al.   PSYCHIATRY RESEARCH

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

(2016) Imanuel Lerman et al.   PSYCHONEUROENDOCRINOLOGY

Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes

(2016) Abigail Powers et al.   NEURAL PLASTICITY

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature

(2015) James B. Lohr et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Association ofCRPGenetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of Trauma

(2015) Vasiliki Michopoulos et al.   AMERICAN JOURNAL OF PSYCHIATRY

C-reactive protein and inflammation: conformational changes affect function

(2015) Yi Wu et al.   BIOLOGICAL CHEMISTRY

Elevated Risk for Autoimmune Disorders in Iraq and Afghanistan Veterans with Posttraumatic Stress Disorder

(2015) Aoife O’Donovan et al.   BIOLOGICAL PSYCHIATRY

Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

(2015) Roshini Prakash et al.   CURRENT OPINION IN NEUROLOGY

Evidence for Epigenetic Regulation of Pro-Inflammatory Cytokines, Interleukin-12 and Interferon Gamma, in Peripheral Blood Mononuclear Cells from PTSD Patients

(2015) Marpe Bam et al.   Journal of Neuroimmune Pharmacology

Gene networks specific for innate immunity define post-traumatic stress disorder

(2015) M S Breen et al.   MOLECULAR PSYCHIATRY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?

(2015) M. Slevin et al.   Scientific Reports

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Elevated Maternal C-Reactive Protein and Increased Risk of Schizophrenia in a National Birth Cohort

(2014) Sarah Canetta et al.   AMERICAN JOURNAL OF PSYCHIATRY

Relationship of PTSD Symptoms With Combat Exposure, Stress, and Inflammation in American Soldiers

(2014) M. W. Groer et al.   Biological Research for Nursing

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal complement C1q and increased odds for psychosis in adult offspring

(2014) Emily G. Severance et al.   SCHIZOPHRENIA RESEARCH

Sleep restoration is associated with reduced plasma C-reactive protein and depression symptoms in military personnel with sleep disturbance after deployment

(2014) Morgan Heinzelmann et al.   SLEEP MEDICINE

Association Between Traumatic Brain Injury and Risk of Posttraumatic Stress Disorder in Active-Duty Marines

(2014) Kate A. Yurgil et al.   JAMA Psychiatry

Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk

(2014) Satish A. Eraly et al.   JAMA Psychiatry

Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis

(2014) M Tursich et al.   Translational Psychiatry

New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease

(2014) James P. Fuller et al.   Frontiers in Neuroscience

Association between posttraumatic stress disorder and inflammation: A twin study

(2013) Laura Plantinga et al.   BRAIN BEHAVIOR AND IMMUNITY

Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment

(2013) Daniel Lindqvist et al.   BRAIN BEHAVIOR AND IMMUNITY

Understanding posttraumatic stress disorder: insights from the methylome

(2013) S. Malan-Müller et al.   GENES BRAIN AND BEHAVIOR

Effects of C-reactive protein on the neutrophil respiratory burst in vitro

(2013) Martin R Ling et al.   Innate Immunity

Human CRP Defends against the Toxicity of Circulating Histones

(2013) S. T. Abrams et al.   JOURNAL OF IMMUNOLOGY

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

Inflammation and Early-Life Abuse in Women

(2012) Elizabeth R. Bertone-Johnson et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

(2012) Randall D. Wight et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study

(2012) Aoife O’Donovan et al.   BRAIN BEHAVIOR AND IMMUNITY

The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure

(2012) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

(2012) Hung Hsuchou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transforming Growth Factor-β, Macrophage Colony-Stimulating Factor and C-Reactive Protein Levels Correlate with CD14highCD16+ Monocyte Induction and Activation in Trauma Patients

(2012) Sonlee D. West et al.   PLoS One

Early Trauma and Inflammation

(2012) Cherie Rooks et al.   PSYCHOSOMATIC MEDICINE

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Biomarkers of PTSD: Neuropeptides and immune signaling

(2011) Dewleen G. Baker et al.   NEUROPHARMACOLOGY

Suppressed monocyte gene expression profile in men versus women with PTSD

(2010) Thomas C. Neylan et al.   BRAIN BEHAVIOR AND IMMUNITY

A short review on the psychoneuroimmunology of posttraumatic stress disorder: From risk factors to medical comorbidities

(2010) Thaddeus W.W. Pace et al.   BRAIN BEHAVIOR AND IMMUNITY

Central memory CD4+ T cells dominate the normal cerebrospinal fluid

(2010) Marieke T. de Graaf et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Proinflammatory cytokines in the cerebrospinal fluid of patients with lumbar radiculopathy

(2010) Seiji Ohtori et al.   EUROPEAN SPINE JOURNAL

Corticotropin-Releasing Factor, Interleukin-6, Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor-1, and Substance P in the Cerebrospinal Fluid of Civilians With Posttraumatic Stress Disorder Before and After Treatment With Paroxetine

(2010) Omer Bonne et al.   JOURNAL OF CLINICAL PSYCHIATRY

Epigenetic and immune function profiles associated with posttraumatic stress disorder

(2010) M. Uddin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks

(2009) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Modified C-Reactive Protein Is Expressed by Stroke Neovessels and Is a Potent Activator of Angiogenesis In Vitro

(2009) Mark Slevin et al.   BRAIN PATHOLOGY

Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder

(2009) E.A. Hoge et al.   DEPRESSION AND ANXIETY

The complement system in schizophrenia

(2009) K.R. Mayilyan et al.   DRUG NEWS & PERSPECTIVES

Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: Evidence from the general population

(2009) Carsten Spitzer et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Mechanisms of C-Reactive Protein-Induced Blood–Brain Barrier Disruption

(2009) Christoph R.W. Kuhlmann et al.   STROKE

C-reactive protein induces M-CSF release and macrophage proliferation

(2008) S. Devaraj et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats

(2008) Ying-Na Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Complement C4B protein in schizophrenia

(2008) Karine R. Mayilyan et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY