Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review

Theracurmin inhibits intestinal polyp development in Apc ‐mutant mice by inhibiting inflammation‐related factors

(2020) Saeko Adachi et al.   CANCER SCIENCE

Synergistic Combinations of Curcumin, Sulforaphane, and Dihydrocaffeic Acid against Human Colon Cancer Cells

(2020) Jesús Santana-Gálvez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

(2020) Rita Maria Concetta Di Martino et al.   ACS Chemical Neuroscience

Antibacterial Mechanism of Curcumin: A Review

(2020) Dantong Zheng et al.   CHEMISTRY & BIODIVERSITY

Oral co-delivery nanoemulsion of 5-fluorouracil and curcumin for synergistic effects against liver cancer

(2020) Pu Guo et al.   Expert Opinion on Drug Delivery

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

(2019) Viktoriya Ivasiv et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Curcumin analogues and their hybrid molecules as multifunctional drugs

(2019) Sawsan A. Noureddin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Oxindole–Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection

(2019) Yoko Hirata et al.   ACS Chemical Neuroscience

Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment

(2019) Chelliah Selvam et al.   LIFE SCIENCES

Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells

(2018) Sougata Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis

(2017) P Zhang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway

(2017) Sandeep Shrestha et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Regulation of inflammation, antioxidant production, and methyl-carbon metabolism during methionine supplementation in lipopolysaccharide-challenged neonatal bovine hepatocytes

(2017) Qian Zhang et al.   JOURNAL OF DAIRY SCIENCE

Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

(2017) Pan Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sequel of MgO nanoparticles in PLACL nanofibers for anti-cancer therapy in synergy with curcumin/β-cyclodextrin

(2017) Shruthi Vathaluru Sudakaran et al.   Materials Science & Engineering C-Materials for Biological Applications

Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo

(2017) Hui-Hui Zhang et al.   MOLECULAR CARCINOGENESIS

Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles

(2017) Qing Yao et al.   MOLECULAR PHARMACEUTICS

Curcumin mediated down-regulation of αV β3 integrin and up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) in Erlotinib resistant SW480 colon cancer cells

(2017) Samira Javadi et al.   PHYTOTHERAPY RESEARCH

Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer

(2017) Yiqun Shao et al.   OncoTargets and Therapy

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

(2017) Christopher A. Kerantzas et al.   mBio

Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells

(2017) Bin He et al.   Oncology Letters

Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1 Patients

(2017) Teresa Esposito et al.   Nutrients

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells

(2017) Huiying Zhao et al.   Cancer Medicine

Effects and synergy of feed ingredients on canine neoplastic cell proliferation

(2016) Corri B. Levine et al.   BMC Veterinary Research

Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon

(2016) Haogang Duan et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dual drug-loaded biofunctionalized amphiphilic chitosan nanoparticles: Enhanced synergy between cisplatin and demethoxycurcumin against multidrug-resistant stem-like lung cancer cells

(2016) Wei-Ting Huang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Changes in the chemical properties and anti-oxidant activities of curcumin by microwave radiation

(2016) Yu Na Jung et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Potentiator synergy in rectal organoids carrying S1251N, G551D, or F508del CFTR mutations

(2016) Johanna F. Dekkers et al.   Journal of Cystic Fibrosis

Discovery of New Monocarbonyl Ligustrazine–Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer

(2016) Yong Ai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment

(2016) Brian C. Jordan et al.   LIFE SCIENCES

TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma

(2016) Longzhu Piao et al.   Oncotarget

A novel aminoclay–curcumin hybrid for enhanced chemotherapy

(2016) Suhang Wang et al.   Journal of Materials Chemistry B

Short peptide based nanotubes capable of effective curcumin delivery for treating drug resistant malaria

(2016) Shadab Alam et al.   JOURNAL OF NANOBIOTECHNOLOGY

Radiolabeled Polymeric Nanoconstructs Loaded with Docetaxel and Curcumin for Cancer Combinatorial Therapy and Nuclear Imaging

(2015) Cinzia Stigliano et al.   ADVANCED FUNCTIONAL MATERIALS

The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity

(2015) Karin Linnewiel-Hermoni et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma

(2015) Bo Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas

(2015) Alfeu Zanotto-Filho et al.   CANCER LETTERS

Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

(2015) Yunes Panahi et al.   CLINICAL NUTRITION

Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells

(2015) Yuqi Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin

(2015) Ji Ho Kang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C

(2015) Jing Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro

(2015) Jian-Ye Zhang et al.   MOLECULES

Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

(2015) Li Lv et al.   Advanced Healthcare Materials

Curcuma zedoaria (Berg.) Rosc. essential oil and paclitaxel synergistically enhance the apoptosis of SKOV3 cells

(2015) YUNXIAO ZHOU et al.   Molecular Medicine Reports

Targeted Delivery of Curcumin to Tumors via PEG-Derivatized FTS-Based Micellar System

(2014) Yichao Chen et al.   AAPS Journal

Discovery of 5-(4-Hydroxyphenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide as a Neuroprotectant for Alzheimer’s Disease by Hybridization of Curcumin and Melatonin

(2014) Jeremy E. Chojnacki et al.   ACS Chemical Neuroscience

β-Cyclodextrin and Curcumin, a Potent Cocktail for Disaggregating and/or Inhibiting Amyloids: A Case Study with α-Synuclein

(2014) Saurabh Gautam et al.   BIOCHEMISTRY

Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer’s disease therapy

(2014) Yujie Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells

(2014) Padmamalini Thulasiraman et al.   BMC CANCER

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

(2014) Sarandeep S. S. Boyanapalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synergistic Effect of Curcumin in Combination with Anticancer Agents in Human Retinoblastoma Cancer Cell Lines

(2014) Seethalakshmi Sreenivasan et al.   CURRENT EYE RESEARCH

Improvement of Bioavailability and Anti-Inflammatory Potential of Curcumin in Combination with Emu Oil

(2014) Manish Kumar Jeengar et al.   INFLAMMATION

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study

(2014) Pascal F. Durrenberger et al.   JOURNAL OF NEURAL TRANSMISSION

Curcumin inhibits the increase of labile zinc and the expression of inflammatory cytokines after traumatic spinal cord injury in rats

(2014) Hongbin Ni et al.   JOURNAL OF SURGICAL RESEARCH

A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

(2014) Longyan Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluating the costs and benefits of using combination therapies

(2014) Philip M Clarke et al.   MEDICAL JOURNAL OF AUSTRALIA

Hybrid Curcumin Compounds: A New Strategy for Cancer Treatment

(2014) Marie-Hélène Teiten et al.   MOLECULES

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

(2014) Kavirayani Priyadarsini   MOLECULES

Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling

(2014) HAITAO YIN et al.   ONCOLOGY REPORTS

Visualization of Network Target Crosstalk Optimizes Drug Synergism in Myocardial Ischemia

(2014) Xiaojing Wan et al.   PLoS One

Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors

(2014) Filip Janku et al.   Cell Reports

Synergy of bone marrow transplantation and curcumin ensue protective effects at early onset of diabetes in mice 在早期发病的糖尿病小鼠中使用骨髓移植和姜黄素联合治疗具有协同保护作用

(2014) Arivarasan Arivazhagan et al.   Journal of Diabetes

Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature

(2013) Sugata Barui et al.   BIOMATERIALS

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

(2013) Hideaki Ogiwara et al.   CARCINOGENESIS

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

pH-Sensitive Nanoparticles of Curcumin–Celecoxib Combination: Evaluating Drug Synergy in Ulcerative Colitis Model

(2013) Dalapathi Gugulothu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The possible roles of vitamin D and curcumin in treating gonorrhea

(2013) Dima A. Youssef et al.   MEDICAL HYPOTHESES

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma

(2013) Kai Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF- B signaling pathway in vitro and in vivo

(2012) F. Tian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats

(2012) Mallikarjun B. Chougala et al.   CLINICAL NUTRITION

Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin

(2012) Linda Saxe Einbond et al.   FITOTERAPIA

Perifosine sensitizes curcumin-induced anti-colorectal cancer effects by targeting multiple signaling pathways bothin vivoandin vitro

(2012) Min-Bin Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells

(2012) Md. Motarab Hossain et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin-Arteether Combination Therapy of Plasmodium berghei-Infected Mice Prevents Recrudescence Through Immunomodulation

(2012) Palakkod G. Vathsala et al.   PLoS One

Knockdown of Ki-67 by Dicer-Substrate Small Interfering RNA Sensitizes Bladder Cancer Cells to Curcumin-Induced Tumor Inhibition

(2012) Sivakamasundari Pichu et al.   PLoS One

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Sensitization of Head and Neck Cancer to Cisplatin Through the Use of a Novel Curcumin Analog

(2011) Waleed M. Abuzeid et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

(2011) Jeffrey D Altenburg et al.   BMC CANCER

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

(2011) Karuppaiyah Selvendiran et al.   CANCER BIOLOGY & THERAPY

Synergistic apoptotic effect of Arabinoxylan rice bran (MGN-3/Biobran) and Curcumin (Turmeric) on human multiple myeloma cell line U266 in vitro

(2011) M. GHONEUM et al.   NEOPLASMA

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Protective Effect of Curcumin and its Combination with Piperine (Bioavailability Enhancer) Against Haloperidol-Associated Neurotoxicity: Cellular and Neurochemical Evidence

(2010) Mahendra Bishnoi et al.   NEUROTOXICITY RESEARCH

Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid

(2009) Constance Lay Lay Saw et al.   BIOCHEMICAL PHARMACOLOGY

Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin

(2009) Kirti Mishra et al.   MALARIA JOURNAL

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Combination of antiangiogenesis with chemotherapy for more effective cancer treatment

(2008) J. Ma et al.   MOLECULAR CANCER THERAPEUTICS

Inflammation

(2008) Ursula Weiss   NATURE

Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids

(2008) Malisetty V. Swamy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions

(2007) Xiaoyong Wang et al.   FOOD CHEMISTRY