Article
Developmental Biology
Nicole Roberto, Isabelle Becam, Anne Plessis, Robert A. Holmgren
Summary: Morphogen gradients require robustness and can be tailored for specific tissues through negative regulators and feedback loops. In the Drosophila wing imaginal disc, genes like Engrailed and Roadkill modulate Hh signaling and affect the formation of the Hh gradient.
Review
Cell Biology
Josie E. Bircher, Anthony J. Koleske
Summary: The Trio family of proteins, including Trio and kalirin, play crucial roles in regulating cell morphology, tissue organization, and protein trafficking, and have been linked to various human diseases. Their functions are carried out through interactions with cell surface receptors, substrates, and various partners, making them important players in cytoskeletal dynamics and protein trafficking pathways.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biology
Justine M. Pinskey, Tyler M. Hoard, Xiao-Feng Zhao, Nicole E. Franks, Zoe C. Frank, Alexandra N. McMellen, Roman J. Giger, Benjamin L. Allen
Summary: Hedgehog signaling is crucial throughout the life of an organism, and this study reveals Plexin as a novel component of this pathway and investigates its functionality and mechanism of action.
Article
Anatomy & Morphology
Li Xu, Caixia Ji, Tingting Yu, Jinyong Luo
Summary: Diseases such as bone nonunion and osteoporosis seriously impact people's quality of life, and bone tissue engineering using mesenchymal stem cells is an effective solution. Previous studies have shown the efficacy of BMP9 in promoting osteogenic differentiation of MSCs, but the underlying mechanisms remain unclear. This study investigated the role of Gli1 and Gli2 in BMP9-induced osteogenic differentiation of MSCs. The results demonstrated that inhibition of Gli1 and Gli2 weakened BMP9-induced osteogenic differentiation and reduced the expression of key osteogenic markers, as well as the activation of p-Smad1/5/8 and p-p38 induced by BMP9. In conclusion, this study highlights the importance of Gli1 and Gli2 in BMP9-induced osteogenic differentiation.
Article
Biology
Shu Yang, Xuefeng Wu, Euphrosyne Daoutidou, Ya Zhang, MaryJane Shimell, Kun-Han Chuang, Aidan J. Peterson, Michael B. O'Connor, Xiaoyan Zheng
Summary: This study reveals a novel mechanism by which the Hedgehog (Hh) protein modulates the activity of Bone Morphogenetic Proteins (BMPs) in the developing Drosophila wing. The findings suggest that Hh-induced expression of the Nord protein fine-tunes the range and strength of BMP signaling by regulating their release and activity. Nord acts as a dosage-dependent BMP modulator, promoting signaling at low levels and inhibiting it at high levels.
Review
Cell Biology
Lucia Sophie Kilian, Jakob Voran, Derk Frank, Ashraf Yusuf Rangrez
Summary: RhoA, as a founding member of the Rho GTPase superfamily, plays a critical role in controlling actin dynamics and regulating various physiological functions such as cardiac remodeling and cardiomyopathies. However, its specific role in the development of cardiomyopathies remains unclear due to conflicting study results.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Cell Biology
Philip P. Yost, Abdulqater Al-Nouman, Jennifer Curtiss
Summary: In this study, the effects of Rap1, a small GTPase, on the development of different cell types in the Drosophila melanogaster eye were investigated. It was found that the activity of Rap1 is regulated by the Delta/Notch signaling pathway and plays a role in determining cell fate during eye development. Manipulation of Rap1 function also affected cone cell contact switching, primary pigment cell enwrapment, and sorting of secondary and tertiary pigment cells. These findings suggest that Rap1 is involved in both cell recruitment/survival and morphogenesis during pupal eye development, providing a basis for further research on its role in these events.
Review
Biochemistry & Molecular Biology
Wiwin Is Effendi, Tatsuya Nagano
Summary: The hedgehog pathway is important for cell specification and proliferation, and can be reactivated in adulthood to contribute to tissue-injury-associated diseases such as IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sri Pratima Nandamuri, Sarah Lusk, Kristen M. Kwan
Summary: Cilia play an essential role in the development and function of various tissues. However, their specific role in early eye development and morphogenesis is still not well understood. This study used a zebrafish dzip1 mutant to investigate eye development and found that the loss of cilia resulted in eye malformation. The misplacement of neural crest cells during optic fissure closure was identified as a potential cause of the eye malformation.
Review
Cell Biology
Shouying Xu, Chao Tang
Summary: The Hedgehog signaling pathway plays a crucial role in the developmental processes of multicellular organisms. Cholesterol is essential for the maturation, secretion, and transduction of Hedgehog protein, and the pathway also has reciprocal effects on cholesterol metabolism and homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christophe Ferrante, Lionel Cavin
Summary: Since the split of the coelacanth lineage from other osteichthyans 420 million years ago, the morphological disparity of this clade has remained remarkably stable. Only few outliers with peculiar body shape stood out over the evolutionary history, but they were phylogenetically and stratigraphically independent of each other. Here, we report the discovery of a new clade of ancient latimeriid coelacanths representing a small flock of species present in the Western Tethys between 242 and 241 million years ago.
SCIENTIFIC REPORTS
(2023)
Review
Microbiology
Eve Wai Ling Chow, Li Mei Pang, Yue Wang
Summary: Candida albicans is a major fungal pathogen in humans, capable of causing both commensalism and infections. Its virulence is attributed to its ability to transition between yeast and filamentous forms.
Article
Genetics & Heredity
Uira Souto Melo, Juliette Piard, Bjorn Fischer-Zirnsak, Marius-Konstantin Klever, Robert Schopflin, Martin Atta Mensah, Manuel Holtgrewe, Francine Arbez-Gindre, Alain Martin, Virginie Guigue, Dominique Gaillard, Emilie Landais, Virginie Roze, Valerie Kremer, Rajeev Ramanah, Christelle Cabrol, Frederike L. Harms, Uwe Kornak, Malte Spielmann, Stefan Mundlos, Lionel Van Maldergem
Summary: This study investigated the molecular basis of bilateral isolated lung agenesis in three fetuses, revealing a complex genomic rearrangement involving regulatory elements for lung development. The rearrangement led to the formation of new 3D chromatin structures, potentially causing the observed lung malformations.
Article
Plant Sciences
Daewon Kim, Jiyuan Yang, Fangwei Gu, Sungjin Park, Jonathon Combs, Alexander Adams, Heather B. Mayes, Su Jeong Jeon, Jeong Dong Bahk, Erik Nielsen
Summary: This study identified a temperature-sensitive root hair mutant, feronia-temperature sensitive (fer-ts), through genetic screening and mapping, revealing a temperature-dependent regulation mechanism for root hair formation.
Article
Multidisciplinary Sciences
Abdel Rahman Abdel Fattah, Brian Daza, Gregorius Rustandi, Miguel Angel Berrocal-Rubio, Benjamin Gorissen, Suresh Poovathingal, Kristofer Davie, Jorge Barrasa-Fano, Mar Condor, Xuanye Cao, Derek Hadar Rosenzweig, Yunping Lei, Richard Finnell, Catherine Verfaillie, Maurilio Sampaolesi, Peter Dedecker, Hans Van Oosterwyck, Stein Aerts, Adrian Ranga
Summary: The complex spatial organization of tissues is achieved through a combination of gene regulatory networks, cell-cell communication, and mechanical forces. Applying active mechanical forces to developing neural tubes can increase growth and enhance patterning in organoids. Organoids respond to mechanical regulation through a temporally restricted competence window, mediated by matrix stiffness, cytoskeleton contractility, and planar cell polarity.
NATURE COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Ashley Truong, M. Mercedes Sayago, William H. Kutteh, Raymond W. Ke
FERTILITY AND STERILITY
(2016)
Article
Cell Biology
Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden
Article
Biology
Daniel P. Stewart, Suresh Marada, William J. Bordeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M. Pruett-Miller, Stacey K. Ogden
Review
Cell Biology
Eric T. Hall, Elizabeth R. Cleverdon, Stacey K. Ogden
TRENDS IN CELL BIOLOGY
(2019)
Article
Cell Biology
Mengle Shao, Qianbin Zhang, Ashley Truong, Bo Shan, Lavanya Vishvanath, Lin Li, Patrick Seale, Rana K. Gupta
Summary: The protein-protein interaction between ZFP423 and EBF2 plays a crucial role in maintaining the identity of white adipocytes and preventing browning. Disruption of this interaction leads to widespread browning of WAT. ZFP423 controls the thermogenic plasticity of adipocytes by regulating EBF2 coactivator recruitment and PPAR gamma occupancy.
GENES & DEVELOPMENT
(2021)
Article
Biology
Eric T. Hall, Stacey K. Ogden
Review
Developmental Biology
Tanushree Pandit, Stacey K. Ogden
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2017)
Article
Developmental Biology
William J. Bodeen, Suresh Marada, Ashley Truong, Stacey K. Ogden
Meeting Abstract
Biochemistry & Molecular Biology
Tanja Mittag, Jill Bouchard, Erik Martin, Joel Otero, Suresh Marada, Stacey Ogden
Article
Multidisciplinary Sciences
Suresh Marada, Ashley Truong, Stacey K. Ogden
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)