The latest advances in the reproductive toxicity of microcystin-LR

A new method for the simultaneous determination of cyanotoxins (Microcystins and Cylindrospermopsin) in mussels using SPE-UPLC-MS/MS

(2020) Leticia Díez-Quijada Jiménez et al.   ENVIRONMENTAL RESEARCH

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

(2020) Tomomi Kuwana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between cyanobacterial bloom impacted drinking water sources and hepatocellular carcinoma incidence rates

(2020) Tyler Gorham et al.   HARMFUL ALGAE

A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins

(2020) Yingzheng Wang et al.   REPRODUCTIVE TOXICOLOGY

A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium

(2020) Fei Yang et al.   WATER RESEARCH

Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial Strains

(2020) Vittoria Mallia et al.   Toxins

The behaviors of Microcystis aeruginosa and microcystins during the Fe2+/persulfate (PS) preoxidation-coagulation and flocs storage period

(2020) Qi Song et al.   ENVIRONMENTAL RESEARCH

In vitro assessment of cyanotoxins bioaccessibility in raw and cooked mussels

(2020) Leticia Díez-Quijada Jiménez et al.   FOOD AND CHEMICAL TOXICOLOGY

The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice

(2020) Xiannan Meng et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Subcellular localization of microcystin in the liver and the gonads of medaka fish acutely exposed to microcystin-LR

(2019) Qin Qiao et al.   TOXICON

piRNA‐DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin‐leucine arginine

(2019) Ruitong Han et al.   PROSTATE

Microcystin-LR in peripheral circulation worsens the prognosis partly through oxidative stress in patients with hepatocellular carcinoma

(2019) Feifei Lei et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Microcystin-LR disturbs testicular development of giant freshwater prawn Macrobrachium rosenbergii

(2019) Yingying Zhang et al.   CHEMOSPHERE

Microcystin-LR influences the in vitro oocyte maturation of zebrafish by activating the MAPK pathway

(2019) Wanjing Liu et al.   AQUATIC TOXICOLOGY

Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings

(2019) Zorica Svirčev et al.   ARCHIVES OF TOXICOLOGY

p53 ‐Dependent pathway and the opening of mPTP mediate the apoptosis of co‐cultured Sertoli‐germ cells induced by microcystin‐LR

(2019) Jinxia Wu et al.   ENVIRONMENTAL TOXICOLOGY

A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity

(2019) Xiannan Meng et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Down-regulation of GCLC is involved in microcystin-LR-induced malignant transformation of human liver cells

(2019) Xuejiao Jia et al.   TOXICOLOGY

Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways

(2019) Yuan Zhou et al.   ENVIRONMENTAL POLLUTION

Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway

(2019) Ji Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A Review of Cardiovascular Toxicity of Microcystins

(2019) Linghui Cao et al.   Toxins

Effects of Microcystin-LR on the Microstructure and Inflammation-Related Factors of Jejunum in Mice

(2019) Linghui Cao et al.   Toxins

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

(2019) Du et al.   Toxins

The Interplay between Ca2+ Signaling Pathways and Neurodegeneration

(2019) Ureshino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Bayesian risk assessment framework for microcystin violations of drinking water and recreational standards in the Bay of Quinte, Lake Ontario, Canada

(2019) Noreen E. Kelly et al.   WATER RESEARCH

Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells

(2019) Yueqin Wang et al.   CHEMOSPHERE

Responses of the proteome in testis of mice exposed chronically to environmentally relevant concentrations of Microcystin-LR.

(2019) Yuan Zhou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Microcystin-LR exposure decreased the fetal weight of mice by disturbance of placental development and ROS-mediated endoplasmic reticulum stress in the placenta

(2019) Sujuan Zhao et al.   ENVIRONMENTAL POLLUTION

Fucoidan alleviates microcystin-LR-induced hepatic, renal, and cardiac oxidative stress and inflammatory injuries in mice

(2019) Abdullah A. AlKahtane et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Deciphering miRNAs’ Action through miRNA Editing

(2019) Marta Correia de Sousa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microcystin-LR triggers different endoplasmic reticulum stress pathways in the liver, ovary, and offspring of zebrafish (Danio rerio)

(2019) Chunhua Zhan et al.   JOURNAL OF HAZARDOUS MATERIALS

Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice

(2019) Xiping Yi et al.   International Journal of Environmental Research and Public Health

Daphnia enhances relative reproductive allocation in response to toxic microcystis: Changes in the performance of parthenogenetic and sexual reproduction

(2019) Qiming Zhou et al.   ENVIRONMENTAL POLLUTION

Microcystin-LR promotes zebrafish (Danio rerio) oocyte (in vivo) maturation by activating ERK1/2-MPF signaling pathways, and cAMP is involved in this process

(2019) Chunhua Zhan et al.   ENVIRONMENTAL POLLUTION

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels

(2018) Yabing Chen et al.   AQUATIC TOXICOLOGY

N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes

(2018) Sujuan Zhao et al.   CHEMOSPHERE

Developmental neurotoxicity of Microcystis aeruginosa in the early life stages of zebrafish

(2018) Haifeng Qian et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of MCLR exposure on sex hormone synthesis and reproduction-related genes expression of testis in male Rana nigromaculata

(2018) Xiuying Jia et al.   ENVIRONMENTAL POLLUTION

Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: In vitro and in vivo evidence

(2018) Jie Hou et al.   ENVIRONMENTAL POLLUTION

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice

(2018) Jie Ding et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells

(2018) Hong-qiang Chen et al.   TOXICOLOGY LETTERS

Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation

(2018) Haohao Liu et al.   Toxins

Single and combined exposure of microcystin-LR and nitrite results in reproductive endocrine disruption via hypothalamic-pituitary-gonadal-liver axis

(2018) Wang Lin et al.   CHEMOSPHERE

Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus

(2018) Jing Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia

(2018) Chun Pan et al.   ENVIRONMENTAL POLLUTION

Transgenerational effects of cyanobacterial toxins on a tropical micro-crustacean Daphnia lumholtzi across three generations

(2018) Thanh-Son Dao et al.   ENVIRONMENTAL POLLUTION

Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway

(2018) E.O. Adegoke et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries

(2018) Haohao Liu et al.   Frontiers in Physiology

Cyanobacteria reduce motility of quagga mussel (Dreissena rostriformis bugensis ) sperm

(2018) Anna G. Boegehold et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Disruption of oocyte maturation by selected environmental chemicals in zebrafish

(2018) Era Maskey et al.   TOXICOLOGY IN VITRO

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis

(2017) Yabing Chen et al.   ENVIRONMENTAL POLLUTION

Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring

(2017) Qin Wu et al.   ENVIRONMENTAL POLLUTION

MicroRNA expression profiling involved in MC-LR-induced hepatotoxicity using high-throughput sequencing analysis

(2017) Shu Yang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

FoxM1: Repurposing an oncogene as a biomarker

(2017) Deeptashree Nandi et al.   SEMINARS IN CANCER BIOLOGY

From the Cover: Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis

(2017) Ling Zhang et al.   TOXICOLOGICAL SCIENCES

Toxic effects of microcystin-LR on the development of prostate in mice

(2017) Hui Zhang et al.   TOXICOLOGY

Expression analysis of microRNAs and mRNAs in ovarian granulosa cells after microcystin-LR exposure

(2017) Xiaoyan Li et al.   TOXICON

Vertical transmission of microcystins to Nile crocodile ( Crocodylus niloticus ) eggs

(2017) Alukhethi Singo et al.   TOXICON

Cyanobacterial Toxins in Freshwater and Food: Important Sources of Exposure to Humans

(2017) Jiyoung Lee et al.   Annual Review of Food Science and Technology

Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish

(2016) Yujing Su et al.   AQUATIC TOXICOLOGY

Microcystin-LR induced developmental toxicity and apoptosis in zebrafish ( Danio rerio ) larvae by activation of ER stress response

(2016) Mei Qi et al.   CHEMOSPHERE

Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo

(2016) Qin Wu et al.   ENVIRONMENTAL POLLUTION

Determination of Environmental Exposure to Microcystin and Aflatoxin as a Risk for Renal Function Based on 5493 Rural People in Southwest China

(2016) Hui Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A review of reproductive toxicity of microcystins

(2016) Liang Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons

(2016) Xueting Wang et al.   TOXICON

Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish

(2016) Wanjing Liu et al.   Scientific Reports

miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice

(2016) Xiannan Meng et al.   Toxins

Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species

(2016) Hui Huang et al.   Frontiers in Physiology

Microcystin-LR impairs zebrafish reproduction by affecting oogenesis and endocrine system

(2015) Yanyan Zhao et al.   CHEMOSPHERE

Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans

(2015) Yunhui Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MC-LR Exposure Leads to Subfertility of Female Mice and Induces Oxidative Stress in Granulosa Cells

(2015) Jiang Wu et al.   Toxins

Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR

(2014) Jie Hou et al.   AQUATIC TOXICOLOGY

Microcystin-LR exposure to adult zebrafish (Danio rerio) leads to growth inhibition and immune dysfunction in F1 offspring, a parental transmission effect of toxicity

(2014) Wanjing Liu et al.   AQUATIC TOXICOLOGY

Endocrine-disrupting effects and reproductive toxicity of low dose MCLR on male frogs (Rana nigromaculata) in vivo

(2014) Xiuying Jia et al.   AQUATIC TOXICOLOGY

The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos

(2014) Cheng Zeng et al.   AQUATIC TOXICOLOGY

Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions

(2014) Zhuo-Jia Chen et al.   ARCHIVES OF TOXICOLOGY

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

(2014) Lan-Tao Gou et al.   CELL RESEARCH

Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96

(2014) Yuan Zhou et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The role of Pten/Akt signaling pathway involved in BPA-induced apoptosis of rat sertoli cells

(2014) Chengmin Wang et al.   ENVIRONMENTAL TOXICOLOGY

First report of microcystin-producing Fischerella sp. (Stigonematales, Cyanobacteria) in tropical Australia

(2014) Samuel Cirés et al.   TOXICON

Female zebrafish (Danio rerio) are more vulnerable than males to microcystin-LR exposure, without exhibiting estrogenic effects

(2013) Qin Qiao et al.   AQUATIC TOXICOLOGY

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Distribution of microcystin-LR to testis of male Sprague–Dawley rats

(2013) Lihui Wang et al.   ECOTOXICOLOGY

Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients

(2013) Elizabeth D. Hilborn et al.   PLoS One

Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro

(2013) Yu Chen et al.   TOXICON

Can We Effectively Degrade Microcystins? - Implications on Human Health

(2012) Armah A. de la Cruz et al.   Anti-Cancer Agents in Medicinal Chemistry

Toxic effects of microcystin-LR on the reproductive system of male Rana nigromaculata in vitro

(2012) Hangjun Zhang et al.   AQUATIC TOXICOLOGY

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation

(2012) Nicholas J. Leeper et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Assessment of microcystin distribution and biomagnification in tissues of aquatic food web compartments from a shallow lake and evaluation of potential risks to public health

(2012) Theodoti Papadimitriou et al.   ECOTOXICOLOGY

The toxic effects of microcystin-LR on rat spermatogonia in vitro

(2012) Yuan Zhou et al.   TOXICOLOGY LETTERS

The role of environmental estrogens and autoimmunity

(2011) Cecilia Chighizola et al.   AUTOIMMUNITY REVIEWS

Global Gene Expression Profiling in Larval Zebrafish Exposed to Microcystin-LR and Microcystis Reveals Endocrine Disrupting Effects of Cyanobacteria

(2011) Emily D. Rogers et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR

(2011) Guangyu Li et al.   PROTEOMICS

Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR

(2011) Yu Chen et al.   REPRODUCTIVE TOXICOLOGY

Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system

(2011) Xueting Wang et al.   TOXICON

Regulation of Akt signaling activation by ubiquitination

(2010) Wei-Lei Yang et al.   CELL CYCLE

Mitochondria, spermatogenesis and male infertility

(2010) Singh Rajender et al.   MITOCHONDRION

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

(2010) Alexandra Schubert-Unkmeir et al.   PLoS Pathogens

Microcystins from tap water could be a risk factor for liver and colorectal cancer: A risk intensified by global change

(2009) Juan Martínez Hernández et al.   MEDICAL HYPOTHESES

Endocrine/paracrine control of zebrafish ovarian development

(2009) Eric Clelland et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes

(2009) Predrag Krajacic et al.   PHYSIOLOGICAL GENOMICS

Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms

(2009) Jun Chen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro

(2008) Yan Li et al.   REPRODUCTIVE TOXICOLOGY

Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates: A review

(2007) Valerio Matozzo et al.   ENVIRONMENT INTERNATIONAL