Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries

Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case-control study in southwest China

(2017) Chuanfen Zheng et al.   HEPATOLOGY

Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

(2017) Soomin Ryu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reproduction impairment and endocrine disruption in female zebrafish after long-term exposure to MC-LR: A life cycle assessment

(2016) Jie Hou et al.   ENVIRONMENTAL POLLUTION

High diversity of microcystins in a Microcystis bloom from an Algerian lake

(2016) Ratiba Bouhaddada et al.   ENVIRONMENTAL POLLUTION

First Identification of the Toxicity of Microcystins on Pancreatic Islet Function in Humans and the Involved Potential Biomarkers

(2016) Yanyan Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A review of neurotoxicity of microcystins

(2016) Yufei Hu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

A review of reproductive toxicity of microcystins

(2016) Liang Chen et al.   JOURNAL OF HAZARDOUS MATERIALS

New Insights on the Mode of Action of Microcystins in Animal Cells - A Review

(2016) Elisabete Valério et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Novel Role of ER Stress and Autophagy in Microcystin-LR Induced Apoptosis in Chinese Hamster Ovary Cells

(2016) Shenshen Zhang et al.   Frontiers in Physiology

Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species

(2016) Hui Huang et al.   Frontiers in Physiology

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

(2015) Xiuhua Zhang et al.   BMC CANCER

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Microcystin-LR impairs zebrafish reproduction by affecting oogenesis and endocrine system

(2015) Yanyan Zhao et al.   CHEMOSPHERE

Polypeptide from Chlamys farreri suppresses ultraviolet-B irradiation-induced apoptosis through restoring ER redox homeostasis, scavenging ROS generation, and suppressing the PERK-eIF2a-CHOP pathway in HaCaT cells

(2015) Feng Zhong et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

The roles of oxidative stress, endoplasmic reticulum stress and autophagy in aldosterone/mineralocorticoid receptor-induced podocyte injury

(2015) Yanggang Yuan et al.   LABORATORY INVESTIGATION

Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells

(2015) Yijia Li et al.   Scientific Reports

MC-LR Exposure Leads to Subfertility of Female Mice and Induces Oxidative Stress in Granulosa Cells

(2015) Jiang Wu et al.   Toxins

Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR

(2014) Jie Hou et al.   AQUATIC TOXICOLOGY

Variation in Cyanobacterial Hepatotoxin (Microcystin) Content of Water Samples and Two Species of Fishes Collected from a Shallow Lake in Algeria

(2014) Amina Amrani et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

High Levels of Structural Diversity Observed in Microcystins from Microcystis CAWBG11 and Characterization of Six New Microcystin Congeners

(2014) Jonathan Puddick et al.   Marine Drugs

Seven new microcystin variants discovered from a nativeMicrocystis aeruginosastrain - unambiguous assignment of product ions by tandem mass spectrometry

(2014) Yulin Qi et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Analysis of Individual and Combined Effects of Ochratoxin A and Zearalenone on HepG2 and KK-1 Cells with Mathematical Models

(2014) Yuzhe Li et al.   Toxins

Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction

(2013) Kai Qu et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages

(2013) Yang Song et al.   AGING CELL

Female zebrafish (Danio rerio) are more vulnerable than males to microcystin-LR exposure, without exhibiting estrogenic effects

(2013) Qin Qiao et al.   AQUATIC TOXICOLOGY

Toxicological evaluation of microcystins in aquatic fish species: Current knowledge and future directions

(2013) Shruti Pavagadhi et al.   AQUATIC TOXICOLOGY

PERK-ing up autophagy during MYC-induced tumorigenesis

(2013) Souvik Dey et al.   Autophagy

Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress

(2013) Jun-Min Shi et al.   BIOCHEMICAL PHARMACOLOGY

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distribution of microcystin-LR to testis of male Sprague–Dawley rats

(2013) Lihui Wang et al.   ECOTOXICOLOGY

State of knowledge and concerns on cyanobacterial blooms and cyanotoxins

(2013) Sylvain Merel et al.   ENVIRONMENT INTERNATIONAL

Reproductive toxicity on female mice induced by microcystin-LR

(2013) Jiang Wu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

κ-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice

(2013) Jing Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Risk assessment of microcystins in silver carp (Hypophthalmichthys molitrix) from eight eutrophic lakes in China

(2013) Dawen Zhang et al.   FOOD CHEMISTRY

Mitochondrial and endoplasmic reticulum pathways involved in microcystin-LR-induced apoptosis of the testes of male frog (Rana nigromaculata) in vivo

(2013) Hangjun Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium

(2012) Mei Shi et al.   APOPTOSIS

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis

(2012) U. Kaasalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microcystin–LR causes cytotoxicity effects in rat testicular Sertoli cells

(2011) Yan Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR

(2011) Yu Chen et al.   REPRODUCTIVE TOXICOLOGY

Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR

(2011) Isabelle Trinchet et al.   REPRODUCTIVE TOXICOLOGY

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Tissue Distribution and Depuration of the Extracted Hepatotoxic Cyanotoxin Microcystins in Crucian Carp (Carassius carassius) Intraperitoneally Injected at a Sublethal Dose

(2011) Hehua Lei et al.   TheScientificWorldJOURNAL

Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning

(2009) Mark C. Yarema et al.   ANNALS OF EMERGENCY MEDICINE

XBP1: the last two decades

(2009) L H Glimcher   ANNALS OF THE RHEUMATIC DISEASES

First evidence of estrogenic potential of the cyanobacterial heptotoxins the nodularin-R and the microcystin-LR in cultured mammalian cells

(2009) Lucie Oziol et al.   JOURNAL OF HAZARDOUS MATERIALS

Transfer, distribution and bioaccumulation of microcystins in the aquatic food web in Lake Taihu, China, with potential risks to human health

(2009) Dawen Zhang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Comparative study of cyanotoxins affecting cytoskeletal and chromatin structures in CHO-K1 cells

(2009) Mariann Gácsi et al.   TOXICOLOGY IN VITRO

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)

(2008) Yasuhiro Tagawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

(2008) Qing Wang et al.   TOXICON

Comparison of S-adenosyl-l-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose

(2007) Marcus V. Terneus et al.   TOXICOLOGY