Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

Genomic Perspectives of Transcriptional Regulation in Forebrain Development

(2015) Alex S. Nord et al.   NEURON

Crafting the Brain – Role of Histone Acetyltransferases in Neural Development and Disease

(2014) Bilal N. Sheikh   CELL AND TISSUE RESEARCH

A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos

(2014) Shipra Bhatia et al.   DEVELOPMENTAL BIOLOGY

The long non-coding RNA Paupar regulates the expression of both local and distal genes

(2014) K. W. Vance et al.   EMBO JOURNAL

Principles of regulatory information conservation between mouse and human

(2014) Yong Cheng et al.   NATURE

Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons

(2014) Gabrielle Pouchelon et al.   NATURE

Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex

(2014) Matthew J Eckler et al.   Neural Development

Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex

(2014) Kartik Pattabiraman et al.   NEURON

Postmitotic control of sensory area specification during neocortical development

(2014) C. Alfano et al.   Nature Communications

Involvement of Genetic and Environmental Factors in the Onset of Depression

(2014) Toshitaka Nabeshima et al.   Experimental Neurobiology

Disruption of Autoregulatory Feedback by a Mutation in a Remote, Ultraconserved PAX6 Enhancer Causes Aniridia

(2013) Shipra Bhatia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

A High-Resolution Enhancer Atlas of the Developing Telencephalon

(2013) Axel Visel et al.   CELL

The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network

(2013) Jovica Ninkovic et al.   Cell Stem Cell

Characterization of Enhancers Active in the Mouse Embryonic Cerebral Cortex Suggests Sox/Pou cis-Regulatory Logics and Heterogeneity of Cortical Progenitors

(2013) A. Bery et al.   CEREBRAL CORTEX

Sp8 and COUP-TF1 Reciprocally Regulate Patterning and Fgf Signaling in Cortical Progenitors

(2013) Ugo Borello et al.   CEREBRAL CORTEX

Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation

(2013) T. Walcher et al.   DEVELOPMENT

Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness

(2013) Tran Cong Tuoc et al.   DEVELOPMENTAL CELL

Epigenetic regulation of neural stem cell fate during corticogenesis

(2013) Chai MuhChyi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

An Allelic Series at the Paired Box Gene 6 (Pax6) Locus Reveals the Functional Specificity ofPaxGenes

(2013) Christian Carbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes

(2013) Marilena Raciti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

From neural development to cognition: unexpected roles for chromatin

(2013) Jehnna L. Ronan et al.   NATURE REVIEWS GENETICS

Molecular logic of neocortical projection neuron specification, development and diversity

(2013) Luciano Custo Greig et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetics and Psychiatry

(2013) Melissa Mahgoub et al.   Neurotherapeutics

Pax6 Interactions with Chromatin and Identification of Its Novel Direct Target Genes in Lens and Forebrain

(2013) Qing Xie et al.   PLoS One

Identification of Genomic Regions Regulating Pax6 Expression in Embryonic Forebrain Using YAC Reporter Transgenic Mouse Lines

(2013) Da Mi et al.   PLoS One

MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain

(2013) T. J. Nowakowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

(2013) G. E. Elsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geniculocortical Input Drives Genetic Distinctions Between Primary and Higher-Order Visual Areas

(2013) S.-J. Chou et al.   SCIENCE

Divergence of Mammalian Higher Order Chromatin Structure Is Associated with Developmental Loci

(2013) Emily V. Chambers et al.   PLoS Computational Biology

The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3

(2013) Mareike Albert et al.   PLoS Genetics

The Enhancer Landscape during Early Neocortical Development Reveals Patterns of Dense Regulation and Co-option

(2013) Aaron M. Wenger et al.   PLoS Genetics

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

(2013) Ohad Shaham et al.   PLoS Genetics

SNF5 Is an Essential Executor of Epigenetic Regulation during Differentiation

(2013) Jueng Soo You et al.   PLoS Genetics

FGF Signalling Regulates Chromatin Organisation during Neural Differentiation via Mechanisms that Can Be Uncoupled from Transcription

(2013) Nishal S. Patel et al.   PLoS Genetics

Transcriptional Analysis of Gli3 Mutants Identifies Wnt Target Genes in the Developing Hippocampus

(2012) Kerstin Hasenpusch-Theil et al.   CEREBRAL CORTEX

A map of the cis-regulatory sequences in the mouse genome

(2012) Yin Shen et al.   NATURE

Pax6: A multi-level regulator of ocular development

(2012) Ohad Shaham et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The role of Pax6 in forebrain development

(2011) Petrina A. Georgala et al.   Developmental Neurobiology

Discovery and assessment of conserved Pax6 target genes and enhancers

(2011) Pedro Coutinho et al.   GENOME RESEARCH

Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus

(2011) Cavit Agca et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer

(2011) Cathy B Moelans et al.   JOURNAL OF PATHOLOGY

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid

(2011) Berry Juliandi et al.   NEUROSCIENCE RESEARCH

Regulation of Pax6 by CTCF during Induction of Mouse ES Cell Differentiation

(2011) Jie Gao et al.   PLoS One

DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region

(2011) David J. McBride et al.   PLoS One

A Mammalian Conserved Element Derived from SINE Displays Enhancer Properties Recapitulating Satb2 Expression in Early-Born Callosal Projection Neurons

(2011) Kensuke Tashiro et al.   PLoS One

Epigenetic control of stem cell fate to neurons and glia

(2010) Hyun-Jung Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

The Generation of Superficial Cortical Layers Is Regulated by Levels of the Transcription Factor Pax6

(2010) Petrina A. Georgala et al.   CEREBRAL CORTEX

The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone

(2010) Y. Suda et al.   DEVELOPMENT

Widespread transcription at neuronal activity-regulated enhancers

(2010) Tae-Kyung Kim et al.   NATURE

The Transcription Factor Pax6 Regulates Survival of Dopaminergic Olfactory Bulb Neurons via Crystallin αA

(2010) Jovica Ninkovic et al.   NEURON

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

(2010) J. D. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

(2010) F. Bedogni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular pathology of schizophrenia—Focus on histone and DNA modifications

(2009) Schahram Akbarian   BRAIN RESEARCH BULLETIN

Mechanisms Underlying the Specification, Positional Regulation, and Function of the Cortical Hem

(2009) L. Subramanian et al.   CEREBRAL CORTEX

Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution

(2009) Bárbara Pernaute et al.   DEVELOPMENTAL DYNAMICS

Selective Cortical Layering Abnormalities and Behavioral Deficits in Cortex-Specific Pax6 Knock-Out Mice

(2009) T. C. Tuoc et al.   JOURNAL OF NEUROSCIENCE

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex

(2009) Shen-Ju Chou et al.   NATURE NEUROSCIENCE

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Differential Regulation of Telencephalic Pallial–Subpallial Boundary Patterning by Pax6 and Gsh2

(2008) Rosalind S.E. Carney et al.   CEREBRAL CORTEX

The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation

(2008) Nicolas Tétreault et al.   DEVELOPMENTAL BIOLOGY

Frontal cortex subdivision patterning is coordinately regulated byFgf8,Fgf17, andEmx2

(2008) Jeremy A. Cholfin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Altered Molecular Regionalization and Normal Thalamocortical Connections in Cortex-Specific Pax6 Knock-Out Mice

(2008) M. C. Pinon et al.   JOURNAL OF NEUROSCIENCE

Bhlhb5 Regulates the Postmitotic Acquisition of Area Identities in Layers II-V of the Developing Neocortex

(2008) Pushkar S. Joshi et al.   NEURON

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

(2008) Dirk A. Kleinjan et al.   PLoS Genetics

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

(2008) M MEHLER   PROGRESS IN NEUROBIOLOGY

Epigenetic background of neuronal fate determination

(2008) Shu Wen et al.   PROGRESS IN NEUROBIOLOGY

Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate

(2008) V. S. Mangale et al.   SCIENCE

Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator

(2008) Noriko Osumi et al.   STEM CELLS

Gli2 Is a Novel Regulator of Sox2 Expression in Telencephalic Neuroepithelial Cells

(2008) Hiromi Takanaga et al.   STEM CELLS