LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development

WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation

(2016) Tamara Ouspenskaia et al.   CELL

The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina

(2016) Marine Lacomme et al.   DEVELOPMENT

SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex

(2016) Catherine W.N. Chiu et al.   DEVELOPMENTAL CELL

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

(2016) Manuel Carminati et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

(2016) Manuel Carminati et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

(2016) Lindsey Seldin et al.   eLife

Esophageal development and epithelial homeostasis

(2015) Sanne L. Rosekrans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Progress and renewal in gustation: new insights into taste bud development

(2015) L. A. Barlow   DEVELOPMENT

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

(2015) Vinod Kumar et al.   JOURNAL OF CELL BIOLOGY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

(2015) Mimmi S. Ballard et al.   Cell Reports

How to make an intestine

(2014) J. M. Wells et al.   DEVELOPMENT

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis

(2014) Laura Ahtiainen et al.   DEVELOPMENTAL CELL

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

(2014) Scott E. Williams et al.   NATURE CELL BIOLOGY

Spindle orientation processes in epithelial growth and organisation

(2014) Eleni Panousopoulou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Development of ectodermal organs

(2014) Irma Thesleff et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Black hairy tongue syndrome

(2014) Grigoriy E Gurvits   WORLD JOURNAL OF GASTROENTEROLOGY

Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population

(2014) Aaron D. DeWard et al.   Cell Reports

Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase

(2013) Tomomi Kiyomitsu et al.   CELL

Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions

(2013) Simone Culurgioni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oriented divisions, fate decisions

(2013) Scott E Williams et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular pathways regulating mitotic spindle orientation in animal cells

(2013) M. S. Lu et al.   DEVELOPMENT

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

(2013) Michaela T. Niessen et al.   JOURNAL OF CELL BIOLOGY

NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions

(2013) Lindsey Seldin et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells

(2013) Toshihiro Tanaka et al.   NATURE CELL BIOLOGY

Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero

(2012) Aaron J. Huebner et al.   DEVELOPMENTAL CELL

Mechanisms regulating epidermal stem cells

(2012) Benjamin Beck et al.   EMBO JOURNAL

Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease

(2011) Jason R. Rock et al.   Annual Review of Cell and Developmental Biology

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development

(2011) Xavier Morin et al.   DEVELOPMENTAL CELL

A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells

(2011) Elise Peyre et al.   JOURNAL OF CELL BIOLOGY

Oblique Radial Glial Divisions in the Developing Mouse Neocortex Induce Self-Renewing Progenitors outside the Germinal Zone That Resemble Primate Outer Subventricular Zone Progenitors

(2011) A. Shitamukai et al.   JOURNAL OF NEUROSCIENCE

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

(2011) Jinwei Zhu et al.   MOLECULAR CELL

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Mouse Inscuteable Induces Apical-Basal Spindle Orientation to Facilitate Intermediate Progenitor Generation in the Developing Neocortex

(2011) Maria Pia Postiglione et al.   NEURON

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

(2011) S. Culurgioni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

(2011) S. Yuzawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Par3 Controls Epithelial Spindle Orientation by aPKC-Mediated Phosphorylation of Apical Pins

(2010) Yi Hao et al.   CURRENT BIOLOGY

Robust control of mitotic spindle orientation in the developing epidermis

(2010) Nicholas D. Poulson et al.   JOURNAL OF CELL BIOLOGY

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells

(2009) Christopher A. Johnston et al.   CELL

Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells

(2009) Ying V. Zhang et al.   Cell Stem Cell

Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence

(2009) Rebecca J. Richardson et al.   HUMAN MOLECULAR GENETICS

Dynamic expression of epidermal caspase 8 simulates a wound healing response

(2009) Pedro Lee et al.   NATURE

Spindle orientation during asymmetric cell division

(2009) Karsten H. Siller et al.   NATURE CELL BIOLOGY

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Hair Follicle Stem Cells Are Specified and Function in Early Skin Morphogenesis

(2008) Jonathan A. Nowak et al.   Cell Stem Cell

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

(2008) Danelle Devenport et al.   NATURE CELL BIOLOGY

Cell Lineage Mapping of Taste Bud Cells and Keratinocytes in the Mouse Tongue and Soft Palate

(2008) Tadashi Okubo et al.   STEM CELLS