Shape matters: The application of activity‐based in vitro bioassays and chiral profiling to the pharmacological evaluation of synthetic cannabinoid receptor agonists in drug‐infused papers seized in prisons

Combination of stable isotope ratio data and chromatographic impurity signatures as a comprehensive concept for the profiling of highly prevalent synthetic cannabinoids and their precursors

(2020) Sascha Münster-Müller et al.   ANALYTICA CHIMICA ACTA

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market

(2020) Caitlyn Norman et al.   Drug Testing and Analysis

Designer drugs: mechanism of action and adverse effects

(2020) Dino Luethi et al.   ARCHIVES OF TOXICOLOGY

Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) synthesised from catechol and eugenol via 4-allylcatechol

(2020) Erin Heather et al.   FORENSIC SCIENCE INTERNATIONAL

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

(2020) Alexander Gillis et al.   Science Signaling

In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

(2020) Marthe M. Vandeputte et al.   ARCHIVES OF TOXICOLOGY

In vitro activity profiling of Cumyl‐PEGACLONE variants at the CB 1 receptor: Fluorination versus isomer exploration

(2020) Liesl Janssens et al.   Drug Testing and Analysis

Cannabinoids and Cannabinoid Receptors: The Story so Far

(2020) Fred Shahbazi et al.   iScience

The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent‐4en and but‐3en analogues including MDMB‐4en‐PINACA

(2020) Alex J. Krotulski et al.   Drug Testing and Analysis

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

Diverse GPCRs exhibit conserved water networks for stabilization and activation

(2019) A. J. Venkatakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional evaluation of carboxy metabolites of synthetic cannabinoid receptor agonists featuring scaffolds based on L‐valine or L‐ tert ‐leucine

(2019) Elise Wouters et al.   Drug Testing and Analysis

Chemical profiling of the synthetic cannabinoid MDMB‐CHMICA: identification, assessment and stability study of synthesis‐related impurities in seized and synthesized samples

(2019) Sascha Münster‐Müller et al.   Drug Testing and Analysis

Profiling of synthesis‐related impurities of the synthetic cannabinoid Cumyl‐5F‐PINACA in seized samples of e‐liquids via multivariate analysis of UHPLC/MS n data

(2019) Sascha Münster‐Müller et al.   Drug Testing and Analysis

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids

(2019) Shivani Sachdev et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthetic cannabinoid receptor agonists: classification and nomenclature

(2019) A. J. Potts et al.   CLINICAL TOXICOLOGY

Review of the most common chemometric techniques in illicit drug profiling

(2019) Ana Popovic et al.   FORENSIC SCIENCE INTERNATIONAL

Case Report: Synthetic Cannabinoid Deaths in State of Florida Prisoners

(2019) Jessica A Hvozdovich et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Attribution of fentanyl analogue synthesis routes by multivariate data analysis of orthogonal mass spectral data

(2019) Lina Mörén et al.   TALANTA

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

(2019) Besma Benredjem et al.   Nature Communications

Analysis of synthetic cannabinoids on paper before and after processing for latent print using DFO and ninhydrin

(2019) Jacquelyn Caterino et al.   FORENSIC SCIENCE INTERNATIONAL

Common activation mechanism of class A GPCRs

(2019) Qingtong Zhou et al.   eLife

Enzymatic asymmetric synthesis of chiral amino acids

(2018) Ya-Ping Xue et al.   CHEMICAL SOCIETY REVIEWS

Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds

(2018) Clara T. Schoeder et al.   Forensic Toxicology

Analytical evidence to show letters impregnated with novel psychoactive substances are a means of getting drugs to inmates within the UK prison service

(2018) Loretta T Ford et al.   ANNALS OF CLINICAL BIOCHEMISTRY

A Novel Impurity-Profiling Workflow with the Combination of Flash-Chromatography, UHPLC-MS, and Multivariate Data Analysis for Highly Pure Drugs: A Study on the Synthetic Cannabinoid MDMB-CHMICA

(2018) Sascha Münster-Müller et al.   ANALYTICAL CHEMISTRY

Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold hopping analogue of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA

(2018) Samuel D. Banister et al.   Drug Testing and Analysis

Simultaneous chiral impurity analysis of methamphetamine and its precursors by supercritical fluid chromatography–tandem mass spectrometry

(2018) Hiroki Segawa et al.   Forensic Toxicology

Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors

(2018) Carolina Noble et al.   Drug Testing and Analysis

Variation in chemical profiles within large seizures of cocaine bricks

(2017) Louise Stride Nielsen et al.   FORENSIC SCIENCE INTERNATIONAL

Evaluation of carboxamide-type synthetic cannabinoids as CB1/CB2 receptor agonists: difference between the enantiomers

(2017) Takahiro Doi et al.   Forensic Toxicology

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

Cocaine profiling: Implementation of a predictive model by ATR-FTIR coupled with chemometrics in forensic chemistry

(2017) Stefano Materazzi et al.   TALANTA

Profiling of cocaine using ratios of GC-MS peaks

(2017) Palle Villesen et al.   Scientific Reports

Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues

(2016) Samuel D. Banister et al.   ACS Chemical Neuroscience

Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay

(2016) Annelies Cannaert et al.   ANALYTICAL CHEMISTRY

Characterization of the synthetic cannabinoid MDMB-CHMCZCA

(2016) Carina Weber et al.   Beilstein Journal of Organic Chemistry

Absolute configuration of the synthetic cannabinoid MDMB-CHMICA with its chemical characteristics in illegal products

(2016) Lars Andernach et al.   Forensic Toxicology

Enantioseparation of the carboxamide-type synthetic cannabinoids N -(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1 H -indazole-3-carboxamide and methyl [1-(5-fluoropentyl)-1 H -indazole-3-carbonyl]-valinate in illicit herbal products

(2016) Takahiro Doi et al.   JOURNAL OF CHROMATOGRAPHY A

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA

(2015) Samuel D. Banister et al.   ACS Chemical Neuroscience

Enantiomer Profiling of Methamphetamine in White Crystal and Tablet Forms (Ma Old) Using LC–MS-MS

(2015) Ting Wang et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Synthetic Cannabinoid–Related Illnesses and Deaths

(2015) Jordan Trecki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

(2014) Guido F. Pauli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain

(2012) Robert F. Wolff et al.   CURRENT MEDICAL RESEARCH AND OPINION

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

The profiling of MDMA tablets: A study of the combination of physical characteristics and organic impurities as sources of information

(2009) Quentin Milliet et al.   FORENSIC SCIENCE INTERNATIONAL