Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

“Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York

(2017) Axel J. Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues

(2016) Samuel D. Banister et al.   ACS Chemical Neuroscience

Protocols for Molecular Modeling with Rosetta3 and RosettaScripts

(2016) Brian J. Bender et al.   BIOCHEMISTRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Fatal intoxication with synthetic cannabinoid MDMB-CHMICA

(2016) Piotr Adamowicz   FORENSIC SCIENCE INTERNATIONAL

Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice

(2016) Cornelius Hess et al.   Forensic Toxicology

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Acute Poisonings from Synthetic Cannabinoids — 50 U.S. Toxicology Investigators Consortium Registry Sites, 2010–2015

(2016) Anne M. Riederer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA

(2015) Samuel D. Banister et al.   ACS Chemical Neuroscience

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

(2014) V. Rempel et al.   MedChemComm

Two new synthetic cannabinoids, AM-2201 benzimidazole analog (FUBIMINA) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM), and three phenethylamine derivatives, 25H-NBOMe 3,4,5-trimethoxybenzyl analog, 25B-NBOMe, and 2C-N-NBOMe, identified in illegal products

(2013) Nahoko Uchiyama et al.   Forensic Toxicology

Subtleties in GPCR drug discovery: a medicinal chemistry perspective

(2012) Masahiko Fujioka et al.   DRUG DISCOVERY TODAY

7-Alkyl-3-benzylcoumarins: A Versatile Scaffold for the Development of Potent and Selective Cannabinoid Receptor Agonists and Antagonists

(2012) Viktor Rempel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55

(2012) Viktor Rempel et al.   ACS Medicinal Chemistry Letters

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

(2011) Douglas McHugh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Practically Useful: What the RosettaProtein Modeling Suite Can Do for You

(2010) Kristian W. Kaufmann et al.   BIOCHEMISTRY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Spice: A never ending story?

(2009) Rainer Lindigkeit et al.   FORENSIC SCIENCE INTERNATIONAL

Identification of a cannabimimetic indole as a designer drug in a herbal product

(2009) Nahoko Uchiyama et al.   Forensic Toxicology

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands

(2009) Ankur Kapur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

(2009) Volker Auwärter et al.   JOURNAL OF MASS SPECTROMETRY

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

CB2receptors in the brain: role in central immune function

(2007) G A Cabral et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB2receptor-mediated migration of immune cells: it can go either way

(2007) A M Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY