Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors

Activity-Based Detection of Cannabinoids in Serum and Plasma Samples

(2018) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds

(2018) Clara T. Schoeder et al.   Forensic Toxicology

Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS

(2018) Marie Mardal et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of a new tert -leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

(2017) Martijn D.P. Risseeuw et al.   FORENSIC SCIENCE INTERNATIONAL

Acute and residual effects in adolescent rats resulting from exposure to the novel synthetic cannabinoids AB-PINACA and AB-FUBINACA

(2017) Richard C Kevin et al.   JOURNAL OF PSYCHOPHARMACOLOGY

“Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York

(2017) Axel J. Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues

(2016) Samuel D. Banister et al.   ACS Chemical Neuroscience

Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay

(2016) Annelies Cannaert et al.   ANALYTICAL CHEMISTRY

Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC

(2016) Janez Klavž et al.   FORENSIC SCIENCE INTERNATIONAL

Death Associated With the Use of the Synthetic Cannabinoid ADB-FUBINACA

(2016) Kevin G. Shanks et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135

(2015) Samuel D. Banister et al.   ACS Chemical Neuroscience

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA

(2015) Samuel D. Banister et al.   ACS Chemical Neuroscience

A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment

(2015) Robert J. Tait et al.   CLINICAL TOXICOLOGY

Identification of AB-FUBINACA metabolites in authentic urine samples suitable as urinary markers of drug intake using liquid chromatography quadrupole tandem time of flight mass spectrometry

(2015) Svante Vikingsson et al.   Drug Testing and Analysis

Risk of emergency medical treatment following consumption of cannabis or synthetic cannabinoids in a large global sample

(2015) Adam Winstock et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cannabinoids as therapeutic agents in cancer: current status and future implications

(2015) Bandana Chakravarti et al.   Oncotarget

The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse

(2013) Samuel D. Banister et al.   ACS Chemical Neuroscience

Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products

(2013) Nahoko Uchiyama et al.   Forensic Toxicology

Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism

(2013) Melanie Hutter et al.   JOURNAL OF MASS SPECTROMETRY

Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors

(2013) Maheswari Rajasekaran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity

(2012) Lisa K. Brents et al.   BIOCHEMICAL PHARMACOLOGY

Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids

(2012) Tim Sobolevsky et al.   Drug Testing and Analysis

New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products

(2012) Nahoko Uchiyama et al.   Forensic Toxicology

Identification and quantitation of a benzoylindole (2-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone and a naphthoylindole 1-(5-fluoropentyl-1H-indol-3-yl)-(naphthalene-1-yl)methanone (AM-2201) found in illegal products obtained via the Internet and their cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays

(2011) Jun’ichi Nakajima et al.   Forensic Toxicology

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity

(2011) Lisa K. Brents et al.   PLoS One

‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

(2009) Volker Auwärter et al.   JOURNAL OF MASS SPECTROMETRY

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY