Article
Biochemistry & Molecular Biology
Yuluan Wang, Charlotte Soneson, Anna L. Malinowska, Artur Laski, Souvik Ghosh, Alexander Kanitz, Luca F. R. Gebert, Mark D. Robinson, Jonathan Hall
Summary: The study introduced a new class of miR-CLIP probes to capture targetomes of miR-124 and miR-132, revealing overlapping targetomes between isoforms and potential synergistic effects of isomirs. Interestingly, it was found that pre-miR-124 processed into isomiRs can repress targets more strongly than individual treatments with miR-124 and iso-miR-124. Mining the miR-CLIP targetome identified G-bulged target-sites regulated at the protein level by miR-124 but not isomiR-124, proposing a model involving AGO2 helix-7 for site engagement.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sandra Dubes, Anais Soula, Sebastien Benquet, Beatrice Tessier, Christel Poujol, Alexandre Favereaux, Olivier Thoumine, Mathieu Letellier
Summary: This study reveals the molecular mechanism of synapse-specific homeostatic plasticity. The synaptic tagging mechanism, driven by synaptopodin, regulates the enhancement of synaptic strength in a synapse-specific manner. This finding shifts the understanding of homeostatic plasticity towards the idea that the ability for changes depends on the functional and biochemical state of individual synapses.
Review
Biochemistry & Molecular Biology
Lluis Rusinol, Luis Puig
Summary: The Jak/STAT pathways play a crucial role in cytokine signaling and have become a focus of research for immune-mediated inflammatory diseases. Dysfunction of Tyk2, a member of the Jak family, has been linked to protection from psoriasis and prevention of IMID without increasing the risk of serious infections. Deucravacitinib, an allosteric inhibitor that binds to the regulatory domain of Tyk2, has shown greater selectivity and a reduced risk of adverse events. In September 2022, deucravacitinib became the first Tyk2 inhibitor approved for the treatment of moderate-to-severe psoriasis. Tyk2 inhibitors hold promise for the future with the development of newer drugs and broader indications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Shun Yuan, Qi Wu, Zhiwei Wang, Yanjia Che, Sihao Zheng, Yuanyang Chen, Xiaohan Zhong, Feng Shi
Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jessica E. Kenison, Nikolas A. Stevens, Francisco J. Quintana
Summary: Immune tolerance is crucial for disease management, and recent breakthroughs have provided new avenues for therapeutic intervention. This article reviews the mechanisms of immune tolerance and novel methods for inducing it, while updating the progress and challenges in achieving antigen-specific immune tolerance.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou, Jianbin Tong
Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.
Review
Medicine, Research & Experimental
Naoual El Menyiy, Aicha El Allam, Sara Aboulaghras, Imane Jaouadi, Saad Bakrim, Nasreddine El Omari, Mohammad Ali Shariati, Alevtin Miftakhutdinov, Polrat Wilairatana, Mohammad S. Mubarak, Abdelhakim Bouyahya
Summary: Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Natural compounds derived from medicinal plants have shown potential in modulating the inflammatory responses of these diseases, presenting a promising approach for treatment and prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Anik Banerjee, Louise D. McCullough
Summary: Both biological sex and aging play important roles in the host immune response in ischemic stroke. Older women tend to have poorer functional outcomes compared to men, possibly due to their older age at first stroke and increased comorbidities. In addition, the immune response differs between men and women, potentially contributing to sex differences in poststroke recovery.
Article
Immunology
Anne-Charlotte Heba, Simon Toupance, Djesia Arnone, Laurent Peyrin-Biroulet, Anthanase Benetos, Ndeye Coumba Ndiaye
Summary: Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that play a crucial role in maintaining the integrity and stability of the genome. Research has shown a close connection between telomere length dynamics and immune-mediated inflammatory diseases, although the causality between these diseases and telomere attrition remains controversial.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Immunology
Beatriz Garcillan, Miguel Salavert, Jose R. Regueiro, Sabela Diaz-Castroverde
Summary: Patients with immune-mediated inflammatory diseases (IMIDs) receiving biologic therapies may experience attenuated vaccine responses. Certain therapies impair the immunogenicity and antibody responses to vaccines, while others do not affect immune responses. SARS-CoV-2 vaccination appears to be safe and well tolerated in IMID patients, but the efficacy may be reduced compared to healthy individuals.
Review
Cell Biology
Jinying Xu, Yangyang Zheng, Liangjia Wang, Yining Liu, Xishu Wang, Yulin Li, Guangfan Chi
Summary: Studies have shown that microRNA-124 is closely related to the occurrence and development of pathology within the central nervous system. Understanding the molecular regulatory functions and effective delivery methods of miR-124 may hold potential for therapeutic targets in treating central nervous system injuries or diseases.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Oh Chan Kwon, See Young Lee, Jaeyoung Chun, Kyungdo Han, Yuna Kim, Ryul Kim, Min-Chan Park, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This population-based cohort study in Korea found that patients with immune-mediated inflammatory diseases (IMIDs) had a lower risk of all-cause mortality compared to individuals without IMIDs. The risks of cancer-specific and cardiovascular disease-specific mortalities were also lower in IMID patients.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Qian Liu, Yang Shen, Yifang Xiao, Hong Xiang, Ling Chu, Tiansheng Wang, Honghui Liu, Guolin Tan
Summary: miR-124-3p may attenuate type 2 inflammation in AR by regulating IL-4R alpha signaling and may be a promising new target in AR treatment.
INFLAMMATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Alfonso Cordero-Barreal, Djedjiga Ait Eldjoudi, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Recent research has shown that adipokines play important roles not only in adipose signaling, but also in musculoskeletal diseases, potentially impacting disease progression and treatment response.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Yinghong Wang, Xiaojie Hu, Yancai Sun, Yan Huang
Summary: This review focuses on the role of ASIC1a in several inflammatory immune diseases, providing new perspectives for clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Celine Fernando, Agnes Audibert, Francoise Simon, Jamal Tazi, Francois Juge
Article
Virology
Noelie Campos, Renier Myburgh, Aude Garcel, Audrey Vautrin, Laure Lapasset, Erika Schlaepfer Nadal, Florence Mahuteau-Betzer, Romain Najman, Pauline Fornarelli, Katjana Tantale, Eugenia Basyuk, Martial Seveno, Julian P. Venables, Bernard Pau, Edouard Bertrand, Mark A. Wainberg, Roberto F. Speck, Didier Scherrer, Jamal Tazi
Article
Genetics & Heredity
Celine Fernando, Agnes Audibert, Francoise Simon, Jamal Tazi, Francois Juge
Article
Endocrinology & Metabolism
J. Santo, C. Lopez-Herrera, C. Apolit, Y. Bareche, L. Lapasset, C. Chavey, S. Capozi, F. Mahuteau-Betzer, R. Najman, P. Fornarelli, Ic Lopez-Meja, G. Beranger, F. Casas, E-Z Amri, B. Pau, D. Scherrer, J. Tazi
INTERNATIONAL JOURNAL OF OBESITY
(2017)
Article
Cell Biology
Satya K. Kota, David Lleres, Tristan Bouschet, Ryutaro Hirasawa, Alice Marchand, Christina Begon-Pescia, Ildem Sanli, Philippe Arnaud, Laurent Journot, Michael Girardot, Robert Feil
DEVELOPMENTAL CELL
(2014)
Article
Biochemistry & Molecular Biology
Isabel C. Lopez-Mejia, Marion de Toledo, Carine Chavey, Laure Lapasset, Patricia Cavelier, Celia Lopez-Herrera, Karim Chebli, Philippe Fort, Guillaume Beranger, Lluis Fajas, Ez Z. Amri, Francois Casas, Jamal Tazi
Article
Multidisciplinary Sciences
Sophie Martin, Jamal Tazi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Multidisciplinary Sciences
Neus Bayo-Puxan, Ana Paula Terrasso, Sophie Creyssels, Daniel Simao, Christina Begon-Pescia, Marina Lavigne, Sara Salinas, Florence Bernex, Assumpcio Bosch, Vasiliki Kalatzis, Thierry Levade, Ana Maria Cuervo, Philippe Lory, Antonella Consiglio, Catarina Brito, Eric J. Kremer
SCIENTIFIC REPORTS
(2018)
Editorial Material
Cell Biology
Helene Tourriere, Jamal Tazi
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Abdelhamid Mahdi Laaref, Laurent Manchon, Yacine Bareche, Laure Lapasset, Jamal Tazi
Article
Immunology
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Gross, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi
Summary: This study investigated the signaling cascade necessary for macrophage recruitment and activation after injury, using transparent zebrafish larvae as a model system. The findings suggest that inhibiting intracellular Ca-2+ release impairs macrophage recruitment and activation, while ROS is necessary for macrophage activation independently of calcium. Neutrophils were found not to be essential for macrophage recruitment and activation in this process. Additionally, Src family kinases Lyn and Yrk and NF-kappa B were identified as key regulators of macrophage activation in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Christina Begon-Pescia, Stephanie Boireau, Myriam Boyer-Clavel, Georges Lutfalla, Mai Nguyen-Chi
Summary: This study describes an optimized protocol for extracting high-quality RNA from zebrafish macrophages, including the use of an enzyme-free and osmotically controlled buffer for cell dissociation to prevent changes in macrophage activation status and cell mortality, as well as the production of high-integrity RNA from a small number of isolated macrophages.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)