In Silico Identification of New Targets for Diagnosis, Vaccine, and Drug Candidates against Trypanosoma cruzi

In silico analysis of four structural proteins of aphthovirus serotypes revealed significant B and T cell epitopes

(2019) Sohail Raza et al.   MICROBIAL PATHOGENESIS

Cysteine proteases in protozoan parasites

(2018) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool

(2017) Evgeny S Gerasimov et al.   NUCLEIC ACIDS RESEARCH

BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes

(2017) Martin Closter Jespersen et al.   NUCLEIC ACIDS RESEARCH

An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae

(2017) Syed Babar Jamal et al.   PLoS One

Characterization and Diagnostic Application of Trypanosoma cruzi Trypomastigote Excreted-Secreted Antigens Shed in Extracellular Vesicles Released from Infected Mammalian Cells

(2016) Norma L. Bautista-López et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Proteomic profile of circulating immune complexes in chronic Chagas disease

(2016) K. Ohyama et al.   PARASITE IMMUNOLOGY

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

(2016) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

Reevaluating the Trypanosoma cruzi proteomic map: The shotgun description of bloodstream trypomastigotes

(2015) Giselle Villa Flor Brunoro et al.   Journal of Proteomics

The immune epitope database (IEDB) 3.0

(2014) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas disease

(2014) Carylinda Serna et al.   VACCINE

Structures of purine nucleosidase fromTrypanosoma bruceibound to isozyme-specific trypanocidals and a novel metalorganic inhibitor

(2013) Francesca Giannese et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Mitochondrial RNA-Binding Protein GRSF1 Localizes to RNA Granules and Is Required for Posttranscriptional Mitochondrial Gene Expression

(2013) Hana Antonicka et al.   Cell Metabolism

Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids

(2013) M. Branquinha et al.   CURRENT MEDICINAL CHEMISTRY

DoGSiteScorer: a web server for automatic binding site prediction, analysis and druggability assessment

(2012) A. Volkamer et al.   BIOINFORMATICS

Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production

(2012) Siomar C. Soares et al.   JOURNAL OF BIOTECHNOLOGY

The MASP Family of Trypanosoma cruzi: Changes in Gene Expression and Antigenic Profile during the Acute Phase of Experimental Infection

(2012) Sara Lopes dos Santos et al.   PLoS Neglected Tropical Diseases

Genetically attenuated Trypanosoma cruzi parasites as a potential vaccination tool

(2012) Cecilia Pérez Brandan et al.   Bioengineered

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens

(2011) Reza Salavati et al.   International Journal for Parasitology-Drugs and Drug Resistance

Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis

(2010) M. Berg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment

(2010) Priscila VSZ Capriles et al.   BMC GENOMICS

Exocytosis and protein secretion in Trypanosoma

(2010) Anne Geiger et al.   BMC MICROBIOLOGY

Chagas’ disease: an update on immune mechanisms and therapeutic strategies

(2010) Silvia Beatriz Boscardin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Trypanosoma cruzi GP63 Proteins Undergo Stage-Specific Differential Posttranslational Modification and Are Important for Host Cell Infection

(2009) M. M. Kulkarni et al.   INFECTION AND IMMUNITY

Vaccine development against Trypanosoma cruzi and Leishmania species in the post-genomic era

(2009) Eric Dumonteil   INFECTION GENETICS AND EVOLUTION

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruzi

(2009) Daniella C. Bartholomeu et al.   NUCLEIC ACIDS RESEARCH