Cysteine proteases in protozoan parasites

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4

(2018) Pollyana M.S. Melo et al.   PARASITOLOGY INTERNATIONAL

Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

(2018) Juan D. Chaparro et al.   PLoS One

The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells

(2018) Sreejoyee Ghosh et al.   PLoS One

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

(2018) James A. Thomas et al.   Nature Microbiology

Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation

(2017) Edgar Deu   FEBS Journal

DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice

(2017) Yali Han et al.   KOREAN JOURNAL OF PARASITOLOGY

Targeting cysteine proteases in trypanosomatid disease drug discovery

(2017) Leonardo G. Ferreira et al.   PHARMACOLOGY & THERAPEUTICS

The regulation of autophagy differentially affects Trypanosoma cruzi metacyclogenesis

(2017) María Cristina Vanrell et al.   PLoS Neglected Tropical Diseases

The macrophage cytoskeleton acts as a contact sensor upon interaction with Entamoeba histolytica to trigger IL-1β secretion

(2017) Joëlle St-Pierre et al.   PLoS Pathogens

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

(2017) Christine S. Hopp et al.   PLoS Pathogens

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

(2017) Christine R. Collins et al.   PLoS Pathogens

Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate

(2017) Clênia S. Azevedo et al.   Frontiers in Chemistry

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

(2017) Manlio Di Cristina et al.   Nature Microbiology

In vitro effects of cysteine protease inhibitors onTrichomonas foetus–induced cytopathic changes in porcine intestinal epithelial cells

(2016) M. Katherine Tolbert et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Comparative Proteomics and Functional Analysis Reveal a Role ofPlasmodium falciparumOsmiophilic Bodies in Malaria Parasite Transmission

(2016) Pablo Suárez-Cortés et al.   MOLECULAR & CELLULAR PROTEOMICS

MappingPlasmodium falciparumMortality in Africa between 1990 and 2015

(2016) Peter W. Gething et al.   NEW ENGLAND JOURNAL OF MEDICINE

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS)

(2016) Samba O. Sow et al.   PLoS Neglected Tropical Diseases

Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression

(2016) Pierre-André Casgrain et al.   PLoS Pathogens

Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1

(2015) Nayara Cristina Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

(2015) Letícia de Almeida et al.   BIOMEDICINE & PHARMACOTHERAPY

Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis

(2015) Le T. Duong et al.   CALCIFIED TISSUE INTERNATIONAL

Cruzain inhibitors: efforts made, current leads and a structural outlook of new hits

(2015) Karina Martinez-Mayorga et al.   DRUG DISCOVERY TODAY

Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors

(2015) Dietmar Steverding   EXPERIMENTAL PARASITOLOGY

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain

(2015) Brian D. Jones et al.   ACS Medicinal Chemistry Letters

Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials

(2014) Trent Conroy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of a novel otubain-like cysteine protease of Cryptosporidium parvum

(2014) Hye-Lim Ju et al.   PARASITOLOGY INTERNATIONAL

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

(2014) Sam Alsford et al.   PLoS Pathogens

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

(2013) Momar Ndao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

(2013) Momar Ndao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis

(2013) Guanghui Zhao et al.   BMC INFECTIOUS DISEASES

Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L

(2013) Veronika Ehmke et al.   ChemMedChem

Mechanism of Trypanosoma brucei gambiense resistance to human serum

(2013) Pierrick Uzureau et al.   NATURE

Cathepsin B Gene Disruption Induced Leishmania donovani Proteome Remodeling Implies Cathepsin B Role in Secretome Regulation

(2013) Teklu Kuru Gerbaba et al.   PLoS One

Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB

(2013) Jörg Schröder et al.   PLoS One

Determinants for the Development of Visceral Leishmaniasis Disease

(2013) Laura-Isobel McCall et al.   PLoS Pathogens

Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics - results from single oral dose studies in healthy volunteers

(2012) S. Aubrey Stoch et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains

(2012) Sara Christina Stolze et al.   CHEMISTRY & BIOLOGY

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

Falcipain Inhibition as a Promising Antimalarial Target

(2012) Maria Marco et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target

(2012) Dietmar Steverding et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte

(2012) Andrea Ruecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles in Autophagy and Importance in Infectivity of the Two ATG4 Cysteine Peptidases ofLeishmania major

(2012) Roderick A. M. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical Maturation of Two Papain-family Proteases inToxoplasma gondii

(2012) Zhicheng Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

In Vitro and In Vivo Activity of an Organic Tellurium Compound on Leishmania (Leishmania) chagasi

(2012) Isabella Aparecida Salerno Pimentel et al.   PLoS One

In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis

(2012) Carolina de Siqueira Paladi et al.   PLoS Neglected Tropical Diseases

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection

(2011) Eduardo R. Cobo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Falcipain Inhibitors: Optimization Studies of the 2-Pyrimidinecarbonitrile Lead Series†

(2010) Jose M. Coterón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

(2010) Katrien Brak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cathepsin B-like and cell death in the unicellular human pathogen Leishmania

(2010) A K El-Fadili et al.   Cell Death & Disease

In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

(2010) Yen Ting Chen et al.   PLoS Neglected Tropical Diseases

Cruzipain, the Major Cysteine Protease of Trypanosoma cruzi: A Sulfated Glycoprotein Antigen as Relevant Candidate for Vaccine Development and Drug Target. A Review

(2009) Vilma Duschak et al.   CURRENT MEDICINAL CHEMISTRY

Toxoplasma gondiiCathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl

(2009) Eric T. Larson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series

(2009) Rafaela S. Ferreira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity‡

(2009) Iain D. Kerr et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

(2009) Camila Bárbara Cantalupo Lima et al.   KOREAN JOURNAL OF PARASITOLOGY

Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus

(2009) Ilaria Russo et al.   MOLECULAR MICROBIOLOGY

Major cysteine peptidases ofEntamoeba histolyticaare required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity

(2009) Henriette Irmer et al.   MOLECULAR MICROBIOLOGY

A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development

(2009) I. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells

(2009) Dennis J. Grab et al.   PLoS Neglected Tropical Diseases

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Malarial proteases and host cell egress: an ‘emerging’ cascade

(2008) Michael J. Blackman   CELLULAR MICROBIOLOGY

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

(2008) Theresa C. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmodium Food Vacuole Plasmepsins Are Activated by Falcipains

(2008) Mark E. Drew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin

(2008) Robert Huang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

(2008) Shirin Arastu-Kapur et al.   Nature Chemical Biology

Cryptopain-1, a cysteine protease of Cryptosporidium parvum, does not require the pro-domain for folding

(2008) B.-K. NA et al.   PARASITOLOGY

Degradation of human secretory IgA1 and IgA2 by Entamoeba histolytica surface-associated proteolytic activity

(2008) Rosa Maria Garcia-Nieto et al.   PARASITOLOGY INTERNATIONAL

An Entamoeba cysteine peptidase specifically expressed during encystation

(2008) Frank Ebert et al.   PARASITOLOGY INTERNATIONAL

RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

(2008) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases