Eradicating, retaining, balancing, swarming, shuttling and dumping: a myriad of tasks for neutrophils during fungal infection

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

(2020) Paige E. Negoro et al.   mBio

Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus

(2020) Iordana A. Shopova et al.   mBio

During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk

(2020) Yahui Guo et al.   Cell Host & Microbe

Chronic Granulomatous Disease: a Comprehensive Review

(2020) Hsin-Hui Yu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection

(2020) Brendan D. Snarr et al.   PLoS Pathogens

Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo

(2020) Bilal Mir et al.   Cells

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils

(2019) Josephine Fischer et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil–derived acidic mammalian chitinase

(2019) Steven de Jesus Carrion et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

(2019) Rebecca A. Drummond et al.   NATURE IMMUNOLOGY

EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection

(2019) Marc Swidergall et al.   Cell Reports

Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature

(2019) Xiaofan Yang et al.   Cell Communication and Signaling

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection

(2019) Marc Swidergall et al.   JOURNAL OF INFECTIOUS DISEASES

Mac‐1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination

(2019) Juliana C. Silva et al.   JOURNAL OF LEUKOCYTE BIOLOGY

β-glucan–dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment

(2019) Vahid Pazhakh et al.   PLOS BIOLOGY

The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling

(2019) William M Nauseef   CURRENT OPINION IN IMMUNOLOGY

Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis

(2019) Astrid Alflen et al.   IMMUNOBIOLOGY

Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2

(2019) Sheng-Yang Wu et al.   PLoS Pathogens

Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

(2018) Michail S. Lionakis et al.   Annual Review of Immunology

Echinocandin treatment of Candida albicans biofilms enhances neutrophil extracellular trap (NET) formation.

(2018) Amanda R. Hoyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis

(2018) Esther K.S. Lee et al.   Cell Host & Microbe

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

Neutrophil extracellular traps in fungal infection

(2018) Constantin F. Urban et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections

(2018) J. Scott Fites et al.   PLoS Pathogens

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

(2018) Eva Guiducci et al.   Frontiers in Immunology

Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

(2018) Heather L. Clark et al.   Frontiers in Immunology

Host-Derived Leukotriene B4 Is Critical for Resistance against Invasive Pulmonary Aspergillosis

(2018) Alayna K. Caffrey-Carr et al.   Frontiers in Immunology

Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation

(2018) Cynthia M. de Bont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection

(2018) Yan Sun et al.   JOURNAL OF IMMUNOLOGY

JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia

(2018) Avinash Khandagale et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack

(2018) Chad J. Johnson et al.   mBio

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

(2018) Ning-Ning Liu et al.   PLoS Pathogens

The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size

(2018) Katharina Fuchs et al.   EMBO REPORTS

Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size

(2017) Annika Warnatsch et al.   IMMUNITY

Immunotherapeutic approaches to treatment of fungal diseases

(2017) Darius Armstrong-James et al.   LANCET INFECTIOUS DISEASES

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death

(2017) Neta Shlezinger et al.   SCIENCE

Mechanisms involved in the triggering of neutrophil extracellular traps (NETs) by Candida glabrata during planktonic and biofilm growth

(2017) Chad J. Johnson et al.   Scientific Reports

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Cell Intrinsic Galectin-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation

(2017) Sheng-Yang Wu et al.   Frontiers in Immunology

EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans

(2017) Marc Swidergall et al.   Nature Microbiology

Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4

(2016) Donglei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How neutrophils kill fungi

(2016) Roel P. Gazendam et al.   IMMUNOLOGICAL REVIEWS

Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans–Induced Inflammation in Mouse Lungs

(2016) Daiki Endo et al.   INFLAMMATION

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa

(2016) Simon Altmeier et al.   PLoS Pathogens

The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps

(2016) Chad J. Johnson et al.   PLoS Pathogens

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

(2016) Maximilian F. Konig et al.   Frontiers in Immunology

Human neutrophils dump Candida glabrata after intracellular killing

(2015) Fabian Essig et al.   FUNGAL GENETICS AND BIOLOGY

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

(2015) Alayna K. Caffrey et al.   PLoS Pathogens

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

(2014) R. P. Gazendam et al.   BLOOD

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

(2014) Kaan Boztug et al.   NATURE GENETICS

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Candida and Host Determinants of Susceptibility to Invasive Candidiasis

(2013) Michail S. Lionakis et al.   PLoS Pathogens

A Role for NADPH Oxidase in Antigen Presentation

(2013) Gail J. Gardiner et al.   Frontiers in Immunology

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

The Impact of the Host on Fungal Infections

(2011) John R. Perfect   AMERICAN JOURNAL OF MEDICINE

Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

(2011) Thomas E. Kehl-Fie et al.   Cell Host & Microbe

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens