Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells

Long-term environmental exposure to microcystins increases the risk of nonalcoholic fatty liver disease in humans: A combined fisher-based investigation and murine model study

(2020) Yanyan Zhao et al.   ENVIRONMENT INTERNATIONAL

Application of passive sampling for sensitive time-integrative monitoring of cyanobacterial toxins microcystins in drinking water treatment plants

(2019) Libor Jasa et al.   WATER RESEARCH

Learning and memory deficits and Alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR

(2019) Jing Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Assessment of microcystin contamination of Amaranthus hybridus, Brassica oleracea, and Lactuca sativa sold in markets: a case study of Zaria, Nigeria

(2019) Mathias Ahii Chia et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

High ecological and human health risks from microcystins in vegetable fields in southern China

(2019) Lei Xiang et al.   ENVIRONMENT INTERNATIONAL

RAD18 promotes the migration and invasion of esophageal squamous cell cancer via the JNK-MMPs pathway

(2018) Shitao Zou et al.   CANCER LETTERS

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

(2018) Kimberly McClinch et al.   CANCER RESEARCH

The role of IL-8/CXCR2 signaling in microcystin-LR triggered endothelial cell activation and increased vascular permeability

(2018) Limei Chen et al.   CHEMOSPHERE

The differential effects of microcystin-LR on mitochondrial DNA in the hippocampus and cerebral cortex

(2018) Xiaofen Wang et al.   ENVIRONMENTAL POLLUTION

COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer

(2018) Rachana Garg et al.   ONCOGENE

The dose makes the poison

(2018) Liang Chen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells

(2018) Hong-qiang Chen et al.   TOXICOLOGY LETTERS

Exposure routes and health effects of microcystins on animals and humans: A mini-review

(2018) Isaac Yaw Massey et al.   TOXICON

Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia

(2018) Chun Pan et al.   ENVIRONMENTAL POLLUTION

Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway

(2018) Qilong Wang et al.   CHEMOSPHERE

Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose–Response Analysis

(2017) Gail S. Prins et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Management of toxic cyanobacteria for drinking water production of Ain Zada Dam

(2017) Amel Saoudi et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Effects of microcystin-LR and cylindrospermopsin on plant-soil systems: A review of their relevance for agricultural plant quality and public health

(2017) J. Machado et al.   ENVIRONMENTAL RESEARCH

Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case-control study in southwest China

(2017) Chuanfen Zheng et al.   HEPATOLOGY

Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

(2017) C-J Ko et al.   ONCOGENE

Toxic effects of microcystin-LR on the development of prostate in mice

(2017) Hui Zhang et al.   TOXICOLOGY

Microcystin-LR promotes epithelial-mesenchymal transition in colorectal cancer cells through PI3-K/AKT and SMAD2

(2017) Yan Ren et al.   TOXICOLOGY LETTERS

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells

(2017) Javier Rodríguez-Ubreva et al.   Cell Reports

Adsorption of Ten Microcystin Congeners to Common Laboratory-Ware Is Solvent and Surface Dependent

(2017) Stefan Altaner et al.   Toxins

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Physical Activity and Cancer Outcomes: A Precision Medicine Approach

(2016) C. M. Friedenreich et al.   CLINICAL CANCER RESEARCH

Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)

(2016) Panida Lertkiatmongkol et al.   CURRENT OPINION IN HEMATOLOGY

Lettuce irrigated with contaminated water: Photosynthetic effects, antioxidative response and bioaccumulation of microcystin congeners

(2016) Maria do Carmo Bittencourt-Oliveira et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Determination of Environmental Exposure to Microcystin and Aflatoxin as a Risk for Renal Function Based on 5493 Rural People in Southwest China

(2016) Hui Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Inorganic Arsenic–Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model

(2015) Joseph J. Shearer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Microcystins contamination of surface water supply sources in Zaria-Nigeria

(2015) Mathias Ahii Chia et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Effects of Chronic Exposure to Microcystin-LR on Hepatocyte Mitochondrial DNA Replication in Mice

(2015) Xinxiu Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats

(2015) Xiaochun Guo et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Microcystins Induces Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Activation of NF-κB

(2015) Jun Shi et al.   MEDIATORS OF INFLAMMATION

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells

(2015) Maqbool Ahmed et al.   Molecular Cancer

Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation

(2015) Chen Miao et al.   MOLECULAR CARCINOGENESIS

Occupational exposure to pesticides and prostate cancer: a systematic review and meta-analysis

(2015) Anne-Mary Lewis-Mikhael et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Species- and congener-differences in microcystin-LR and -RR GSH conjugation in human, rat, and mouse hepatic cytosol

(2015) Franca M. Buratti et al.   TOXICOLOGY LETTERS

Cadmium Exposure and Cancer Mortality in a Prospective Cohort: The Strong Heart Study

(2014) Esther García-Esquinas et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

Why mammals more susceptible to the hepatotoxic microcystins than fish: evidences from plasma and albumin protein binding through equilibrium dialysis

(2013) Wei Zhang et al.   ECOTOXICOLOGY

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

(2013) Rachana Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D

(2013) I-C Wang et al.   ONCOGENE

Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia

(2013) Jennifer L.O. Merrimen et al.   PATHOLOGY

Microcystin-LR Promotes Melanoma Cell Invasion and Enhances Matrix Metalloproteinase-2/-9 Expression Mediated by NF-κB Activation

(2012) Xu-Xiang Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The link between benign prostatic hyperplasia and prostate cancer

(2012) David D. Ørsted et al.   Nature Reviews Urology

Association of Symptomatic Benign Prostatic Hyperplasia and Prostate Cancer: Results from the Prostate Cancer Prevention Trial

(2011) J. M. Schenk et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer Therapy

(2011) Shahab Uddin et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of microcystin-LR exposure on matrix metalloproteinase-2/-9 expression and cancer cell migration

(2011) Zongyao Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

A Cross-Sectional Investigation of Chronic Exposure to Microcystin in Relationship to Childhood Liver Damage in the Three Gorges Reservoir Region, China

(2011) Yan Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation

(2011) Mónica Alvarez-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxM1 and Its Association with Matrix Metalloproteinases (MMP) Signaling Pathway in Papillary Thyroid Carcinoma

(2011) Maqbool Ahmed et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

SLCO2B1 and SLCO1B3 May Determine Time to Progression for Patients Receiving Androgen Deprivation Therapy for Prostate Cancer

(2011) Ming Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Factors Affecting Temporal and Spatial Variations of Microcystins in Gonghu Bay of Lake Taihu, with Potential Risk of Microcystin Contamination to Human Health

(2011) Qing Wang et al.   TheScientificWorldJOURNAL

Vasoactive intestinal peptide (VIP) induces malignant transformation of the human prostate epithelial cell line RWPE-1

(2010) Ana B. Fernández-Martínez et al.   CANCER LETTERS

Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell Growth

(2010) Nanqin Gan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Strategies to prolong the plasma residence time of peptide drugs

(2010) Lisa Pollaro et al.   MedChemComm

Cadmium Malignantly Transforms Normal Human Breast Epithelial Cells into a Basal-like Phenotype

(2009) Lamia Benbrahim-Tallaa et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

First Identification of the Hepatotoxic Microcystins in the Serum of a Chronically Exposed Human Population Together with Indication of Hepatocellular Damage

(2009) Jun Chen et al.   TOXICOLOGICAL SCIENCES

Human Health Risk Assessment Related to Cyanotoxins Exposure

(2008) Enzo Funari et al.   CRITICAL REVIEWS IN TOXICOLOGY

FoxM1 Regulates Transcription ofJNK1to Promote the G1/S Transition and Tumor Cell Invasiveness

(2008) I-Ching Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY