Small‐Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview

Therapeutic potential of targeting SHP2 in human developmental disorders and cancers

(2020) Dadong Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glioblastome Multiforme: A Bibliometric Analysis

(2020) Manahil Akmal et al.   World Neurosurgery

Turn and Face the Strange: A New View on Phosphatases

(2020) Maja Köhn   ACS Central Science

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors

(2020) Wen-Shan Liu et al.   BIOORGANIC CHEMISTRY

Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review

(2019) Arata Tomiyama et al.   Cancers

Signal transduction pathways and resistance to targeted therapies in glioma

(2019) Arata Tomiyama et al.   SEMINARS IN CANCER BIOLOGY

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors

(2019) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics

(2019) Rui-Rui Wang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors

(2019) Sheisi F. L. S. Rocha et al.   BIOPOLYMERS

Targeting PDGFRα-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling

(2019) Youzhou Sang et al.   NEURO-ONCOLOGY

Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority

(2019) Claire L. Niedzwiedz et al.   BMC CANCER

PD-L1/PD-1 Axis in Glioblastoma Multiforme

(2019) Jakub Litak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway

(2019) Fan Yang et al.   OncoTargets and Therapy

Targeting SHP2 as a promising strategy for cancer immunotherapy

(2019) Qianqian Liu et al.   PHARMACOLOGICAL RESEARCH

Dual Allosteric Inhibition of SHP2 Phosphatase

(2018) Michelle Fodor et al.   ACS Chemical Biology

Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

(2018) X Sun et al.   LEUKEMIA

Current Challenges and Opportunities in Treating Glioblastoma

(2018) Andrea Shergalis et al.   PHARMACOLOGICAL REVIEWS

Probing the Dynamic Mechanism of Uncommon Allosteric Inhibitors Optimized to Enhance Drug Selectivity of SHP2 with Therapeutic Potential for Cancer Treatment

(2018) Abdolkarim Farrokhzadeh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

(2018) Ashfaq Ur Rehman et al.   CURRENT PHARMACEUTICAL DESIGN

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2

(2018) Xiaoqin Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

(2018) Bryan G. Harder et al.   Frontiers in Oncology

SHP2 regulates proliferation and tumorigenicity of glioma stem cells

(2017) Laura Roccograndi et al.   JOURNAL OF NEURO-ONCOLOGY

Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation

(2017) Liang Lu et al.   Cell Death & Disease

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

(2016) Jorge Garcia Fortanet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

(2015) Stefanie Grosskopf et al.   ChemMedChem

Functions of Shp2 in cancer

(2015) Jie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glioblastoma multiforme: Pathogenesis and treatment

(2015) Constantinos Alifieris et al.   PHARMACOLOGY & THERAPEUTICS

Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis

(2014) Wen-Qing Huang et al.   CURRENT CANCER DRUG TARGETS

Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells

(2014) C. M. Furcht et al.   JOURNAL OF CELL SCIENCE

Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

(2013) Zhi-Hong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling

(2013) Liang Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Recent advances in the molecular understanding of glioblastoma

(2012) Fonnet E. Bleeker et al.   JOURNAL OF NEURO-ONCOLOGY

Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma

(2011) L-M Sturla et al.   BRITISH JOURNAL OF CANCER

A note from history: Landmarks in history of cancer, part 1

(2010) Steven I. Hajdu   CANCER

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells

(2009) Yi Zhan et al.   EXPERIMENTAL CELL RESEARCH

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Targeting PTPs with small molecule inhibitors in cancer treatment

(2008) Zhong-Xing Jiang et al.   CANCER AND METASTASIS REVIEWS

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING