Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism

An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

(2020) Richard J. Caselli et al.   Alzheimers & Dementia

Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms

(2019) Lon S. Schneider et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

(2019) Martin Tolar et al.   Alzheimers & Dementia

Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides

(2018) Baiping Ren et al.   ACS Chemical Neuroscience

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

(2018) Michele Zoli et al.   Current Neuropharmacology

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region

(2018) Mukta Agrawal et al.   Expert Opinion on Drug Delivery

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

(2018) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial

(2018) Kejal Kantarci et al.   NEUROLOGY

Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice

(2017) Sin-Woo Kang et al.   TOXICOLOGY LETTERS

Amyloid-β Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells

(2017) Gerard Ill-Raga et al.   JOURNAL OF ALZHEIMERS DISEASE

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

(2016) Jie Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

(2015) Yisong Qian et al.   PHARMACEUTICAL BIOLOGY

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

(2015) Sharadha Dayalan Naidu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer's Disease

(2015) Gargi Chatterjee et al.   Aging and Disease

α7 Nicotinic Acetylcholine Receptor-Specific Antibody Induces Inflammation and Amyloid β42 Accumulation in the Mouse Brain to Impair Memory

(2015) Olena Lykhmus et al.   PLoS One

Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture

(2014) Zhenying Han et al.   JOURNAL OF NEUROCHEMISTRY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Involvement of α7 nAChR Signaling Cascade in Epigallocatechin Gallate Suppression of β-Amyloid-Induced Apoptotic Cortical Neuronal Insults

(2013) Xijing Zhang et al.   MOLECULAR NEUROBIOLOGY

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice

(2012) Rena Li et al.   MOLECULAR NEUROBIOLOGY

Long-term soy isoflavone supplementation and cognition in women: A randomized, controlled trial

(2012) V. W. Henderson et al.   NEUROLOGY

α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice

(2012) M. Hijioka et al.   NEUROSCIENCE

Genistein inhibits aggregation of exogenous amyloid-beta1–40 and alleviates astrogliosis in the hippocampus of rats

(2011) Maryam Bagheri et al.   BRAIN RESEARCH

α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling

(2011) Wenfeng Yu et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimers Disease and Retinal Neurodegeneration

(2010) L. Guo et al.   Current Alzheimer Research

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

(2010) Kyeong-Ah Jung et al.   MOLECULES

Long-Term Primary Culture of Highly-Pure Rat Embryonic Hippocampal Neurons of Low-Density

(2010) Hao Yang et al.   NEUROCHEMICAL RESEARCH

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Thymosin-β4 Attenuates Ethanol-induced Neurotoxicity in Cultured Cerebral Cortical Astrocytes by Inhibiting Apoptosis

(2009) Hao Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

(2009) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of Neuroprotective Effects of Nicotine and Acetylcholinesterase Inhibitors: Role of α4 and α7 Receptors in Neuroprotection

(2009) Akinori Akaike et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Nuclear Factor E2-Related Factor 2-Dependent Myocardiac Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

(2008) Dietmar Rudolf Thal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Comparative Study of β-Amyloid Peptides Aβ1-42 and Aβ25-35 Toxicity in Organotypic Hippocampal Slice Cultures

(2008) Rudimar Luiz Frozza et al.   NEUROCHEMICAL RESEARCH

Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease

(2007) Marina et al.   Frontiers in Bioscience-Landmark

Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

(2007) Li-Xing Liu et al.   NEUROSCIENCE RESEARCH