Review
Neurosciences
Esperanza Mata-Martinez, Mauricio Diaz-Munoz, Francisco G. Vazquez-Cuevas
Summary: Inflammation is a crucial defense mechanism in the body, but chronic activation can lead to various pathological processes. The nervous system is a key focus in the study of inflammation, and understanding the regulation of inflammasomes in the central nervous system is essential for innovation in treatments.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Nour F. Al-Ghraiybah, Junwei Wang, Amer E. Alkhalifa, Andrew B. Roberts, Ruchika Raj, Euitaek Yang, Amal Kaddoumi
Summary: This review provides an overview of recent advances on the role of microglia and astrocytes in neuroinflammation and provides updates on neuroinflammation diagnostic markers and investigational therapeutics currently in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lee Wei Lim, Md . Sahab Uddin
Summary: Alzheimer's disease is a neurodegenerative disorder with unclear pathogenesis. Recent research suggests that microglia and astrocytes may play a role in the development of AD and could be potential therapeutic targets.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell Biology
Elodie Kip, Louise C. Parr-Brownlie
Summary: This article discusses the role of neuroinflammation in the onset and progression of Parkinson's disease (PD) and emphasizes the importance of reducing neuroinflammation early on to prevent PD. The article also mentions some risk and protective factors and discusses treatments for neuroinflammation associated with PD.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli
Summary: This study systematically reviewed the role of glial cells in Lafora disease (LD). The findings suggest that glial cells accumulate polyglucosan bodies (PBs) in LD and contribute to neurodegeneration and epilepsy. Future research should consider glial cells as a potential therapeutic target.
Article
Clinical Neurology
Semra Smajic, Cesar A. Prada-Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre, Carola Dietrich, Javier Jarazo, Jana Henck, Saranya Balachandran, Sinthuja Pachchek, Christopher M. Morris, Paul Antony, Bernd Timmermann, Sascha Sauer, Sandro L. Pereira, Jens C. Schwamborn, Patrick May, Anne Gruenewald, Malte Spielmann
Summary: In this study, the contribution of different cell types to Parkinson's disease pathology was investigated using single-nuclei RNA sequencing. The results revealed a disease-specific neuronal cell cluster and changes in glial cells, as well as the enrichment of Parkinson's disease risk genes. These findings highlight the importance of inflammatory signaling and immunomodulatory treatments in Parkinson's disease.
Review
Immunology
Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wang
Summary: Recent studies have shown that the excessive activation of microglia and release of pro-inflammatory cytokines play crucial roles in the pathogenesis and progression of Parkinson's disease (PD). The elevated level of NLRP3 inflammasome in activated microglia in the substantia nigra of PD patients exacerbates the pathology and accelerates disease progression. Current therapeutic drugs for PD primarily focus on relieving clinical symptoms, as there are no established strategies to stop or reverse the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Haiyang Yu, Qing Chang, Tong Sun, Xin He, Jing An, Lulu Wen, Juan Feng, Yuhong Zhao
Summary: Parkinson's disease is characterized by α-synuclein aggregation and dopaminergic neuronal death. Neuroinflammation is an early event in the pathogenesis of Parkinson's disease. Microglia play a crucial role in neuroinflammation and can be polarized into pro-inflammatory M1 or anti-inflammatory M2 phenotype. Inflammasomes activation and iron accumulation induce metabolic reprogramming in microglia, leading to neuroinflammation and neurodegeneration. Understanding the interplay between microglial polarization and metabolic reprogramming provides potential therapeutic targets for Parkinson's disease and other neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Junhan Liang, Chaolei Wang, Yulin Deng, Zixuan Chen
Summary: Neuroinflammation plays a significant role in the initiation and progression of Parkinson's disease, activating the neuronal immune system and triggering a vicious cycle of inflammation-induced dopaminergic neuron damage. Epigenetic mechanisms are at the forefront of regulating neuroinflammatory factors, offering potential for breaking this cycle. These mechanisms do not work independently but cooperatively, impacting various neuroinflammatory pathways and potentially influencing PD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiaoli Guo, Atsuko Kimura, Kazuhiko Namekata, Chikako Harada, Nobutaka Arai, Kohsuke Takeda, Hidenori Ichijo, Takayuki Harada
Summary: This study found that the lack of ASK1 in microglia/macrophages can reduce neuroinflammation in both early and later stages of experimental autoimmune encephalomyelitis (EAE), while the lack of ASK1 in astrocytes only improves neuroinflammation in the later stage. The deficiency of ASK1 in T cells and dendritic cells has no significant effect on the severity of EAE. These findings demonstrate the cell-type-specific roles of ASK1 and the phase-specific ASK1-dependent glial cell interactions in the pathophysiology of EAE.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Jingru Qiu, Ye Chen, Jing Zhuo, Li Zhang, Jia Liu, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lou
Summary: The study showed that Urolithin A (UA) can protect dopaminergic neurons from loss in Parkinson's disease (PD) by promoting microglial mitophagy and inhibiting neuroinflammation.
Article
Immunology
Dewei He, Shoupeng Fu, Ang Zhou, Yingchun Su, Xiyu Gao, Yufei Zhang, Bingxu Huang, Jian Du, Dianfeng Liu
Summary: The study found that Camptothecin (CPT) can regulate the phenotype of microglia, promote neuroprotection, and inhibit neuroinflammatory responses. Additionally, CPT also protects neurons and neuroblastoma cells from damage caused by microglia activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hung-Li Wang, Yi-Chuan Cheng, Tu-Hsueh Yeh, Han-Fang Liu, Yi-Hsin Weng, Rou-Shayn Chen, Yi-Chun Chen, Juu-Chin Lu, Tsong-Long Hwang, Kuo-Chen Wei, Yu-Chuan Liu, Yu-Ting Wang, Chia-Chen Hsu, Tai-Ju Chiu, Ching-Chi Chiu
Summary: Microglial activation-induced neuroinflammation plays a role in the onset and progression of Parkinson's disease. Activated microglia secrete pro-inflammatory and neurotoxic cytokines, which contribute to neurodegeneration. This study suggests that the activation of microglia through FPR1 leads to loss of dopaminergic neurons by activating inflammasome and upregulating pro-inflammatory cytokines, and that the FPR1 antagonist HCH6-1 has a neuroprotective effect on dopaminergic neurons.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhiyou Yang, Junxin Liu, Shuai Wei, Jiahang Deng, Xinyue Feng, Shucheng Liu, Mingxin Liu
Summary: Alzheimer's disease is an ageing-related neurodegenerative disorder characterized by neuritic plaques and neurofibrillary tangles. Neuroinflammation, especially the activation of NLRP3 inflammasome, plays a crucial role in the pathogenesis of AD. Targeting NLRP3 inflammasome seems to be an efficient strategy for AD treatment through regulating brain immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Janeli Viil, Kelli Somelar-Duracz, Kulli Jaako, Kaili Anier, Alexander Zharkovsky
Summary: Mouse microglial cell line IMG is suitable for studying NLRP3 inflammasome, as it shows stronger upregulation of NLRP3 inflammasome-associated genes and robust activation of inflammasome following short incubation with lipopolysaccharide (LPS) and ATP, respectively. Inhibitor glibenclamide can effectively suppress NLRP3 inflammasome activation in IMG cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Fillipe Mendes De Araujo, Annyta Fernandes Frota, Livia Bacelar de Jesus, Ticiane Caribe Macedo, Lorena Cuenca-Bermejo, Consuelo Sanchez-Rodrigo, Kariny Maria Silva Ferreira, Juciele Valeria Ribeiro de Oliveira, Maria de Fatima Dias Costa, Juan Segura-Aguilar, Silvia Lima Costa, Maria Trinidad Herrero, Victor Diogenes Amaral Silva
Summary: This study observed that aminochrome induced neuroinflammation, including microgliosis, astrogliosis, and dopaminergic neuronal loss, in an in vivo model. The findings reinforce the potential of aminochrome as a useful preclinical model for finding anti-inflammatory and neuroprotective drugs for Parkinson's disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Adriana L. Silva, Joana L. Oliveira, Ravena P. do Nascimento, Leticia O. Santos, Fillipe M. de Aranjo, Balbino L. dos Santos, Rejane C. Santana, Eduardo Luiz T. Moreira, Maria Jose M. Batatinha, Iura M. Alves, Eudes S. Velozo, Mauricio M. Victor, Adriano M. Assis, Roberto F. Almeida, Diogo O. G. de Souza, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The ingestion of MCT induces cerebrovascular lesions and toxicity to neurons in rats, accompanied by astroglial cell response and neuroinflammation in the cortex and hippocampus.
Article
Neurosciences
Fillipe Mendes De Araujo, Annyta F. Frota, Livia B. de Jesus, Lorena Cuenca-Bermejo, Kariny Maria S. Ferreira, Cleonice Creusa Santos, Erica N. Soares, Jessica T. Souza, Flavia S. Sanches, Ana Carla S. Costa, Alana A. Farias, Maria de Fatima Dias Costa, Patricia Munoz, Jose A. Menezes-Filho, Juan Segura-Aguilar, Silvia Lima Costa, Maria Trinidad Herrero, Victor Diogenes Amaral Silva
Summary: The causes of dopaminergic neuronal loss in Parkinson's disease (PD) are not fully understood, but research suggests that a compound called Aminochrome is one of the main contributors. This study found that rutin, a naturally-occurring flavonoid, can protect against Aminochrome-induced cell death and prevent the loss of dopaminergic neurons in animal models of PD.
NEUROTOXICITY RESEARCH
(2023)
Article
Chemistry, Analytical
Nieves Pavon-Pulido, Jesus Damian Blasco-Garcia, Juan Antonio Lopez-Riquelme, Jorge Feliu-Batlle, Roberto Oterino-Bono, Maria Trinidad Herrero
Summary: This paper describes the main results of the JUNO project, which developed a smart assistant robot with capabilities for smart navigation and natural human interaction. The robot is being validated in an elderly institution and focuses on helping people with cognitive stimulation exercises and entertainment activities. It combines classic techniques and new Deep Learning-based methods to carry out requested tasks, and can share information through the Cloud. The paper also discusses limitations and proposes solutions for this complex environment.
Article
Chemistry, Medicinal
Raquel B. M. de Almeida, Deyse B. B. Barbosa, Mayra R. R. do Bomfim, Jessika A. O. Amparo, Bruno S. S. Andrade, Silvia L. L. Costa, Joaquin M. Campos, Jorddy N. Cruz, Cleydson B. R. Santos, Franco H. A. Leite, Mariana B. B. Botura
Summary: The compound ZINC390718 was found to exhibit inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and showed low cytotoxicity in vitro. Molecular dynamics (MD) simulation revealed that ZINC390718 interacted with the catalytic residue sites of both enzymes. These findings suggest that ZINC390718 could be a potential chemotype for the development of new dual cholinesterase inhibitors.
Review
Biochemistry & Molecular Biology
Lorena Cuenca-Bermejo, Alessandro Prinetti, Karolina Kublickiene, Valeria Raparelli, Alexandra M. Kautzky-Willer, Colleen Norris, Louise Pilote, Maria Trinidad Herrero, GOING FWD Consortium
Summary: Brain aging leads to cognitive decline and increased vulnerability to age-related disorders. Lipid metabolism plays a crucial role in brain function, and changes in lipid composition have been linked to aging and neurodegenerative diseases. This study focuses on sex differences in brain lipid changes during aging and in Alzheimer's and Parkinson's diseases. The findings highlight the need to consider sex as an experimental variable in precision medicine research.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Maria del Carmen Macias Ruiz, Lorena Cuenca Bermejo, Nicola Veronese, Emiliano Fernandez Villalba, Ana Maria Gonzalez Cuello, Karolina Kublickiene, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Louise Pilote, Mario Barbagallo, Ligia Dominguez, Maria Trinidad Herrero
Summary: This article reviews the role of magnesium in health and illness, with emphasis on the elderly population with chronic kidney disease (CKD) and potential sex differences. It is found that magnesium can be used as an adjunctive treatment for CKD patients to improve glomerular filtration, but further research and characterization are needed for its clinical applications. Therefore, well-designed prospective clinical trials are needed to establish guidelines for magnesium supplementation, considering age and sex.
Article
Biochemistry & Molecular Biology
M. T. Herrero, J. E. Yuste, L. Cuenca-Bermejo, P. Almela, L. Arenas-Betancur, V. De Pablos, A. Gonzalez-Cuello, E. Del Bel, J. Navarro-Zaragoza, E. Fernandez-Villalba
Summary: This study aimed to determine whether the nitric oxide synthase inhibitor, 7-nitroindazole (7-NI), can reduce L-DOPA-induced dyskinesias (LIDs) in a non-human primate model of Parkinson disease (PD). The results showed that the dyskinetic monkeys treated with 7-NI had a significant decrease in LIDs compared to their scores without 7-NI treatment. However, the anti-Parkinsonian effect of L-DOPA remained unchanged. This study suggests that 7-NI could be a promising therapy to improve the quality of life of PD patients.
Article
Pharmacology & Pharmacy
Balbino Lino dos Santos, Cleonice Creusa dos Santos, Janaina R. P. Soares, Karina C. C. da Silva, Juciele Valeria R. de Oliveira, Gabriele S. S. Pereira, Fillipe M. M. de Araujo, Maria de Fatima D. Costa, Jorge Mauricio David, Victor Diogenes A. da Silva, Arthur Morgan Butt, Silvia Lima Costa
Summary: Agathisflavone from Cenostigma pyramidale has shown neuroprotective effects in in vitro models of glutamate-induced excitotoxicity and inflammatory damage. This study investigated the potential role of agathisflavone in regulating microglia and its neuroprotective effects. The results demonstrated that agathisflavone can inhibit inflammation in microglia and reduce the expression of inflammatory factors, thereby exerting anti-inflammatory and neuroprotective effects.
Article
Integrative & Complementary Medicine
Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro e Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fatima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, Jose Claudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silva
Summary: This study demonstrates that the compound EDAC extracted from Amburana cearensis seeds exhibits cytoprotective activity against ischemia and glutamate excitotoxicity in hippocampal brain slices. EDAC increases the expression of glutamate transporters and glutamine synthetase, modulating astrocyte responses and their glutamate homeostatic mechanisms.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)