Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97
Authors
Keywords
-
Journal
CELL CYCLE
Volume -, Issue -, Pages 1-15
Publisher
Informa UK Limited
Online
2020-12-31
DOI
10.1080/15384101.2020.1860559
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Spironolactone and XPB: An Old Drug with a New Molecular Target
- (2020) Ryan D. Gabbard et al. Biomolecules
- Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCF FBXL18 E3 ligase
- (2019) Masanobu Ueda et al. GENES TO CELLS
- Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin
- (2018) Michael G. Kemp et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Nucleotide excision repair is a potential therapeutic target in multiple myeloma
- (2017) R Szalat et al. LEUKEMIA
- Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin
- (2016) Jinshan He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor
- (2016) Liang Xue et al. MOLECULAR & CELLULAR PROTEOMICS
- UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein
- (2016) Jinshan He et al. Oncotarget
- A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum
- (2014) Sergey Alekseev et al. CHEMISTRY & BIOLOGY
- Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis
- (2014) Jinshan He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair
- (2014) Or David Shahar et al. NUCLEIC ACIDS RESEARCH
- Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
- (2014) Marjo-Riitta Puumalainen et al. Nature Communications
- p97 complexes as signal integration hubs
- (2012) Hemmo Meyer BMC BIOLOGY
- UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
- (2012) Susanne Bandau et al. BMC BIOLOGY
- Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
- (2012) Hemmo Meyer et al. NATURE CELL BIOLOGY
- A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor
- (2011) Jean-Marc Egly et al. DNA REPAIR
- Cdc48: a power machine in protein degradation
- (2011) Alexandra Stolz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Dissociation of CAK from Core TFIIH Reveals a Functional Link between XP-G/CS and the TFIIH Disassembly State
- (2010) Hany H. Arab et al. PLoS One
- UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover
- (2008) Gabriela Alexandru et al. CELL
- Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease
- (2008) Jeong-Sun Ju et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH
- (2008) Frédéric Coin et al. MOLECULAR CELL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now