Article
Medicine, Research & Experimental
Hany H. Arab, Ahmed M. Ashour, Ahmed H. Eid, El-Shaimaa A. Arafa, Hana J. Al Khabbaz, Sarah A. Abd El-Aal
Summary: This study found that galangin can attenuate cadmium-induced nephrotoxicity through reducing oxidative stress and apoptosis, as well as promoting autophagy.
Article
Chemistry, Analytical
Sherif A. Abdel-Gawad, Hany H. Arab
Summary: The application of ion-selective electrodes in the detection and determination of environmental pollutants is crucial. By using membrane electrodes and adjusting assay settings, bromazepam can be accurately measured in real wastewater samples without tedious pretreatment procedures.
Article
Environmental Sciences
Barakat M. ALRashdi, Hassan A. Elgebaly, Mousa O. Germoush, Moath M. Qarmush, Mona S. Azab, Reem S. Alruhaimi, Ahmad F. Ahmeda, Mohammad H. Abukhalil, Emadeldin M. Kamel, Hany H. Arab, Mohammed A. Alzoghaibi, Mohammed F. Alotaibi, Ayman M. Mahmoud
Summary: This study investigated the effects of Monolluma quadrangula extract (MQE) on hyperuricemic rats and found that MQE exhibited renoprotective properties by inhibiting xanthine oxidase activity, reducing oxidative stress and inflammation, and modulating urate transporters.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Alaa M. Alqahtani, Asmaa G. Safi El-Din, Randa Abdou, Ali H. Amin, Hany H. Arab, Ahmed H. Abdelazeem
Summary: A series of novel compounds with a benzothiazolotriazole scaffold were synthesized and evaluated for their antimicrobial activity against bacteria and fungi. The results showed significant antifungal activity but limited antibacterial potential. Compound 7b exhibited the strongest antifungal activity with a low MIC value against Candida albicans and Penicillium chrysogenum.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Article
Medicine, Research & Experimental
Ahmed M. Kabel, Hany H. Arab, Aliaa Atef, Remon S. Estfanous
Summary: The combination of omarigliptin and galangin may be a promising therapeutic approach for mitigating LPS-induced neuroinflammation.
Article
Neurosciences
Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Hany H. Arab
Summary: This study found that rosuvastatin may have a beneficial effect in halting the cognitive decline induced by estrogen decline through interfering with the TLR4/NF-κB/NLRP1/3 axis and inflammasomes activation and the subsequent pyroptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ekta Singh, Riyaz Ali M. Osmani, Rinti Banerjee, Amr Selim Abu Lila, Afrasim Moin, Khaled Almansour, Hany H. Arab, Hadil Faris Alotaibi, El-Sayed Khafagy
Summary: This study developed leflunomide-loaded nanoparticles as a local drug delivery system for the treatment of rheumatoid arthritis. The nanoparticles showed sustained drug release in simulated synovial fluid and demonstrated efficacy in reducing inflammation and immune responses without notable toxicity in animal models. These findings suggest that intra-articularly administered leflunomide nanoparticles could be a potential alternative to systemic drugs for the treatment of rheumatoid arthritis.
Article
Chemistry, Medicinal
Ahmed M. Kabel, Aliaa Atef, Hany M. Borg, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, Hany H. Arab, Remon S. Estfanous
Summary: This study investigated the effects of perindopril and ambrosin, alone or in combination, on DSS-induced colitis in mice. The results showed that both perindopril and ambrosin were able to alleviate oxidative stress, suppress proinflammatory pathways, inhibit apoptosis, and enhance autophagy in colonic tissues. The combination of perindopril and ambrosin had the most remarkable effects compared to either agent alone.
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Amany M. Gad
Summary: The study investigated the neuroprotective potential of magnesium sulfate in a rat model of chronic-restraint stress (CRS)-induced depression-like behavioral disturbance and the underlying molecular mechanisms. The results demonstrated that magnesium sulfate attenuated the depression-like behavioral outcomes and histopathological changes in the brain by dampening inflammation, ER stress, and the associated PERK/GRP78/CHOP pathway. These findings suggest the promising neuroprotective/antidepressant actions of magnesium sulfate in CRS.
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Mostafa K. Mohammad, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Amany M. Gad
Summary: This study demonstrates the potential antidepressant effect of meloxicam in a chronic restraint stress model. Meloxicam improved depression-like behavior, neurohistopathological changes, and decreased neurotransmitter levels. These effects may be mediated through inhibition of the COX-2/NOX1/NOX4 pathway and activation of the Nrf2/HO-1 antioxidant pathway.
Article
Chemistry, Medicinal
Maha M. Abdel-Fattah, Emad H. M. Hassanein, Ahmed M. Sayed, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Hany H. Arab, Wafaa R. Mohamed
Summary: The current study aimed to investigate the ameliorative effect of rebamipide in a rat model of acetic acid-evoked ulcerative colitis and the molecular mechanisms involved. The findings demonstrated that rebamipide significantly improved colonic injury by combating inflammation and oxidative stress, which may be mediated by regulating the SIRT1/FoxO3a/Nrf2 and PI3K/AKT pathways.
Article
Chemistry, Medicinal
Hany H. Arab, Ebtehal Mohammad Fikry, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Abdullah M. Al-Hossaini, Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Ahmed H. Eid
Summary: The study demonstrated that dapagliflozin has a positive effect on Cd-induced testicular dysfunction by improving testicular weight, serum testosterone, and sperm count/motility, and reducing sperm abnormalities. It also showed antioxidative, anti-apoptotic, and pro-autophagic effects to mitigate testicular impairment and spermatogenesis disruption caused by Cd. Therefore, dapagliflozin could be a potential therapeutic tool for the management of Cd-induced testicular dysfunction.
Article
Chemistry, Medicinal
Hany H. Arab, Ahmed H. Eid, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Gehan S. Georgy
Summary: This study investigated the potential neuroprotective effect of linagliptin against cadmium-induced cognitive deficits in rats. The results showed that linagliptin improved learning and memory impairment caused by cadmium and reduced hippocampal neurodegeneration. Additionally, linagliptin regulated the signaling pathways in the hippocampus by inhibiting DPP-4 and increasing GLP-1 levels, resulting in a neuroprotective impact.
Article
Chemistry, Medicinal
Maaly A. Abd Elmaaboud, Remon S. Estfanous, Aliaa Atef, Ahmed M. Kabel, Khalid A. Alnemari, Tamer M. Naguib, Shuruq E. Alsufyani, Hany W. Darwish, Hany H. Arab
Summary: In this study, the potential ameliorative effects of dapagliflozin and/or hesperidin on lipopolysaccharide-induced Alzheimer's disease (AD) were investigated. The results showed that both dapagliflozin and hesperidin improved the biochemical parameters, behavioral tests, and histopathological parameters in a rat model of AD. These favorable effects were significantly enhanced when the two agents were used in combination.
Article
Chemistry, Medicinal
Hany H. Arab, Ahmed H. Eid, Rania Yahia, Shuruq E. Alsufyani, Ahmed M. Ashour, Azza A. K. El-Sheikh, Hany W. Darwish, Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Marwa A. Masoud
Summary: The study found that topiramate has the potential to combat cadmium neurotoxicity and improve cognitive deficits. Topiramate is able to alleviate hippocampal oxidative damage, apoptosis, and autophagy induced by cadmium through multiple mechanisms, as well as increase hippocampal glutamate content and enhance acetylcholine and GABA neurotransmitters. These findings suggest that topiramate may be useful in mitigating cadmium-induced cognitive deficits.