Benzo(a)pyrene-induced cytotoxicity, cell proliferation, DNA damage, and altered gene expression profiles in HT-29 human colon cancer cells

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

(2020) George M. Ramzy et al.   Cancers

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Determination of polycyclic aromatic hydrocarbon content in heat-treated meat retailed in Egypt: Health risk assessment, benzo[a]pyrene induced mutagenicity and oxidative stress in human colon (CaCo-2) cells and protection using rosmarinic and ascorbic acids

(2019) Wageh Sobhy Darwish et al.   FOOD CHEMISTRY

Pharmacokinetics of [ 14 C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

(2018) Jessica M. Hummel et al.   FOOD AND CHEMICAL TOXICOLOGY

Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis

(2018) Ashley C. Huderson et al.   INVESTIGATIONAL NEW DRUGS

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[ a ]pyrene: Effects in human colorectal HCT116 TP53(+/+) , TP53(+/−) and TP53(−/−) cells

(2018) Alexandra J. Willis et al.   TOXICOLOGY

Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models

(2018) Ondřej Zapletal et al.   TOXICOLOGY

Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing

(2018) Erin Madeen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

n-3 Polyunsaturated fatty acids alter benzo[a]pyrene metabolism and genotoxicity in human colon epithelial cell models

(2018) Zuzana Tylichová et al.   FOOD AND CHEMICAL TOXICOLOGY

Benzo[a]pyrene Induces Autophagic and Pyroptotic Death Simultaneously in HL-7702 Human Normal Liver Cells

(2017) Li Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models

(2016) Ondřej Zapletal et al.   ARCHIVES OF TOXICOLOGY

Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice

(2016) Babajide O. Ajayi et al.   FOOD AND CHEMICAL TOXICOLOGY

Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in ApcMin mouse model

(2016) Leah D. Banks et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer

(2016) Kelly L. Harris et al.   Oncotarget

MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo

(2016) Yingqiu Xie et al.   Oncotarget

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi

(2016) Aniekanabassi N. Udoko et al.   PLoS Neglected Tropical Diseases

Human dietary exposure to polycyclic aromatic hydrocarbons: A review of the scientific literature

(2015) José L. Domingo et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation

(2015) Markéta Kabátková et al.   MUTAGENESIS

Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium

(2015) Jiro Sonoda et al.   Journal of Toxicologic Pathology

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

(2014) Laura E. Wohak et al.   ARCHIVES OF TOXICOLOGY

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis

(2013) Kelly L Harris et al.   Expert Opinion on Drug Metabolism & Toxicology

Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer

(2013) Deacqunita L. Diggs et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Understanding the linked kinetics of benzo(a)pyrene and 3-hydroxybenzo(a)pyrene biomarker of exposure using physiologically-based pharmacokinetic modelling in rats

(2013) Roberto Heredia-Ortiz et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Pathogenesis of Human Enterovirulent Bacteria: Lessons from Cultured, Fully Differentiated Human Colon Cancer Cell Lines

(2013) V. Lievin-Le Moal et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Comparative Evaluation of Different Cell Lysis and Extraction Methods for Studying Benzo(a)pyrene Metabolism in HT-29 Colon Cancer Cell Cultures

(2011) Jeremy N. Myers et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2

(2011) Jeanette Niestroy et al.   TOXICOLOGY IN VITRO

Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells

(2010) Hanno Bothe et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures

(2009) Adeline Tarantini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells

(2009) N. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benzo[a]pyrene-induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion

(2008) T. Lin et al.   TOXICOLOGY

Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits

(2007) W.J. de Waard et al.   TOXICOLOGY IN VITRO