Advances and clinical challenges for translating nerve conduit technology from bench to bed side for peripheral nerve repair

Adipose Stem Cells Enhance Nerve Regeneration and Muscle Function In A Peroneal Nerve Ablation Model

(2019) Juliana A. Passipieri et al.   TISSUE ENGINEERING PART A

Adipose-derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model

(2019) Benjamin K. Schilling et al.   MUSCLE & NERVE

3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

(2019) Sanjairaj Vijayavenkataraman et al.   Frontiers in Bioengineering and Biotechnology

Grafted muscle‐derived stem cells promote the therapeutic efficiency of epimysium conduits in mice with peripheral nerve gap injury

(2019) Zhuqiu Xu et al.   ARTIFICIAL ORGANS

Tissue-engineered spiral nerve guidance conduit for peripheral nerve regeneration

(2018) Wei Chang et al.   Acta Biomaterialia

Regenerative potential of chitosan-coated poly-3-hydroxybutyrate conduits seeded with mesenchymal stem cells in a rat sciatic nerve injury model

(2018) Hidir Ozer et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Electrohydrodynamic-jetting (EHD-jet) 3D-printed functionally graded scaffolds for tissue engineering applications

(2018) Sanjairaj Vijayavenkataraman et al.   JOURNAL OF MATERIALS RESEARCH

Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair

(2018) Roghayeh Mozafari et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Rapid continuous 3D printing of customizable peripheral nerve guidance conduits

(2018) Wei Zhu et al.   Materials Today

Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit

(2018) Elias Volkmer et al.   Neural Regeneration Research

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration

(2018) Ying Bu et al.   RSC Advances

Electrohydrodynamic Jet 3D Printed Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

(2018) Sanjairaj Vijayavenkataraman et al.   Polymers

Use new poly (ε-caprolactone/collagen/NBG) nerve conduits along with NGF for promoting peripheral (sciatic) nerve regeneration in a rat

(2018) Forouzan Mohamadi et al.   Artificial Cells Nanomedicine and Biotechnology

Voluntary Exercise Positively Affects the Recovery of Long-Nerve Gap Injury Following Tube-Bridging with Human Skeletal Muscle-Derived Stem Cell Transplantation

(2018) Hiroya Seta et al.   Journal of Clinical Medicine

3D-Printed PCL/rGO Conductive Scaffolds for Peripheral Nerve Injury Repair

(2018) Sanjairaj Vijayavenkataraman et al.   ARTIFICIAL ORGANS

Novel spiral structured nerve guidance conduits with multichannels and inner longitudinally aligned nanofibers for peripheral nerve regeneration

(2018) Munish B. Shah et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Adipose-derived stem cells and the stromal vascular fraction in polyglycolic-acid (PGA)-collagen nerve conduits promote rat facial nerve regeneration

(2018) Mari Shimizu et al.   WOUND REPAIR AND REGENERATION

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

Muscle-derived stem cells: important players in peripheral nerve repair

(2018) Leila Musavi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Poly (lactide-co-glycolide) (PLGA) Scaffold Induces Short-term Nerve Regeneration and Functional Recovery Following Sciatic Nerve Transection in Rats

(2018) Franciele Pereira dos Santos et al.   NEUROSCIENCE

Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo

(2018) Hanna K. Frost et al.   Scientific Reports

Electrohydrodynamic jet 3D-printed PCL/PAA conductive scaffolds with tunable biodegradability as nerve guide conduits (NGCs) for peripheral nerve injury repair

(2018) Sanjairaj Vijayavenkataraman et al.   MATERIALS & DESIGN

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

(2017) Se Heang Oh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Chitosan conduits filled with simvastatin/Pluronic F-127 hydrogel promote peripheral nerve regeneration in rats

(2017) Qi Guo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Bioabsorbable nerve conduits coated with induced pluripotent stem cell-derived neurospheres enhance axonal regeneration in sciatic nerve defects in aged mice

(2017) Takuya Yokoi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Electrospun silk fibroin-based neural scaffold for bridging a long sciatic nerve gap in dogs

(2017) Chengbin Xue et al.   Journal of Tissue Engineering and Regenerative Medicine

Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?

(2017) Kathleen Sanen et al.   Journal of Tissue Engineering and Regenerative Medicine

Stabilization, Rolling, and Addition of Other Extracellular Matrix Proteins to Collagen Hydrogels Improve Regeneration in Chitosan Guides for Long Peripheral Nerve Gaps in Rats

(2017) Francisco Gonzalez-Perez et al.   NEUROSURGERY

Transplantation of Human Dental Pulp-Derived Stem Cells or Differentiated Neuronal Cells from Human Dental Pulp-Derived Stem Cells Identically Enhances Regeneration of the Injured Peripheral Nerve

(2017) Imran Ullah et al.   STEM CELLS AND DEVELOPMENT

Bone Marrow Stromal Cells Associated with Poly L-Lactic-Co-Glycolic Acid (PLGA) Nanofiber Scaff old Improve Transected Sciatic Nerve Regeneration

(2017) Gholamreza Kaka et al.   Iranian Journal of Biotechnology

Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells

(2017) Sa Cai et al.   Stem Cell Reports

Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair

(2017) William A. Lackington et al.   ACS Biomaterials-Science & Engineering

Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair

(2017) William A. Lackington et al.   ACS Biomaterials Science & Engineering

Trophic Effects of Dental Pulp Stem Cells on Schwann Cells in Peripheral Nerve Regeneration

(2016) Tsubasa Yamamoto et al.   CELL TRANSPLANTATION

Peripheral Nerve Regeneration through Hydrogel-Enriched Chitosan Conduits Containing Engineered Schwann Cells for Drug Delivery

(2016) Cora Meyer et al.   CELL TRANSPLANTATION

3D printing of functional biomaterials for tissue engineering

(2016) Wei Zhu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Autograft Substitutes

(2016) Bauback Safa et al.   HAND CLINICS

3D printed nervous system on a chip

(2016) Blake N. Johnson et al.   LAB ON A CHIP

Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue–Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration–Approved Nerve Conduit

(2016) Silvan M. Klein et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Adipose-Derived Stem Cells Promote Peripheral Nerve Regeneration In Vivo without Differentiation into Schwann-Like Lineage

(2016) Yoshihiro Sowa et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Biomimetic Nerve Guidance Conduit Containing Intraluminal Microchannels with Aligned Nanofibers Markedly Facilitates in Nerve Regeneration

(2016) David J. Lee et al.   ACS Biomaterials-Science & Engineering

Biomimetic Nerve Guidance Conduit Containing Intraluminal Microchannels with Aligned Nanofibers Markedly Facilitates in Nerve Regeneration

(2016) David J. Lee et al.   ACS Biomaterials Science & Engineering

A Silk Fibroin/Collagen Nerve Scaffold Seeded with a Co-Culture of Schwann Cells and Adipose-Derived Stem Cells for Sciatic Nerve Regeneration

(2016) Yunqiang Xu et al.   PLoS One

3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration

(2016) Yu Hu et al.   Scientific Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Peripheral nerve regeneration: Experimental strategies and future perspectives

(2015) Alessandro Faroni et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Printed Anatomical Nerve Regeneration Pathways

(2015) Blake N. Johnson et al.   ADVANCED FUNCTIONAL MATERIALS

In vivo studies of silk based gold nano-composite conduits for functional peripheral nerve regeneration

(2015) Suradip Das et al.   BIOMATERIALS

Long-Term Efficacy and Safety Outcomes of Transplantation of Induced Pluripotent Stem Cell-Derived Neurospheres with Bioabsorbable Nerve Conduits for Peripheral Nerve Regeneration in Mice

(2015) Takuya Uemura et al.   CELLS TISSUES ORGANS

Biological conduits combining bone marrow mesenchymal stem cells and extracellular matrix to treat long-segment sciatic nerve defects

(2015) Ke-qiang Zhang et al.   Neural Regeneration Research

Biological behavior of mesenchymal stem cells on poly-ε-caprolactone filaments and a strategy for tissue engineering of segments of the peripheral nerves

(2015) A. Carrier-Ruiz et al.   Stem Cell Research & Therapy

Nerve Guidance Conduits Based on Double-Layered Scaffolds of Electrospun Nanofibers for Repairing the Peripheral Nervous System

(2014) Jingwei Xie et al.   ACS Applied Materials & Interfaces

Conductive polymers: Towards a smart biomaterial for tissue engineering

(2014) Richard Balint et al.   Acta Biomaterialia

A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers

(2014) Andrew Li et al.   BIOMATERIALS

Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair

(2014) Helene T. Khuong et al.   EXPERIMENTAL NEUROLOGY

Recent Advances in Nerve Tissue Engineering

(2014) Bill G.X. Zhang et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Human muscle–derived stem/progenitor cells promote functional murine peripheral nerve regeneration

(2014) Mitra Lavasani et al.   JOURNAL OF CLINICAL INVESTIGATION

Sensory recovery after cell therapy in peripheral nerve repair: effects of naïve and skin precursor-derived Schwann cells

(2014) Antos Shakhbazau et al.   JOURNAL OF NEUROSURGERY

Undifferentiated and differentiated adipose-derived stem cells improve nerve regeneration in a rat model of facial nerve defect

(2014) Yorikatsu Watanabe et al.   Journal of Tissue Engineering and Regenerative Medicine

Peptide functionalized polyhydroxyalkanoate nanofibrous scaffolds enhance Schwann cells activity

(2014) Elahe Masaeli et al.   Nanomedicine-Nanotechnology Biology and Medicine

A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair

(2014) Qingtang Zhu et al.   Neural Regeneration Research

Complementary Effects of Two Growth Factors in Multifunctionalized Silk Nanofibers for Nerve Reconstruction

(2014) Tony M. Dinis et al.   PLoS One

Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration

(2014) Murat Demirbilek et al.   Artificial Cells Nanomedicine and Biotechnology

Engineering Three-Dimensional Collagen-IKVAV Matrix to Mimic Neural Microenvironment

(2013) Hossein Hosseinkhani et al.   ACS Chemical Neuroscience

Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps

(2013) Yun Gu et al.   BIOMATERIALS

Mesenchymal bone marrow stem cells within polyglycolic acid tube observed in vivo after six weeks enhance facial nerve regeneration

(2013) Heloisa Juliana Zabeu Rossi Costa et al.   BRAIN RESEARCH

Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro

(2013) Wendy Martens et al.   FASEB JOURNAL

Nerve Allografts and Conduits in Peripheral Nerve Repair

(2013) Michael Y. Lin et al.   HAND CLINICS

Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system

(2013) Mikinori Ikeda et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Aligned SF/P(LLA-CL)-blended nanofibers encapsulating nerve growth factor for peripheral nerve regeneration

(2013) Zhang Kuihua et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Correction: A Biosynthetic Nerve Guide Conduit Based on Silk/SWNT/Fibronectin Nanocomposite for Peripheral Nerve Regeneration

(2013) Fatemeh Mottaghitalab et al.   PLoS One

Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair

(2012) Takuya Uemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts

(2012) Nan Hu et al.   BIOMATERIALS

Nanofibrous nerve conduit-enhanced peripheral nerve regeneration

(2012) Xu Jiang et al.   Journal of Tissue Engineering and Regenerative Medicine

Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications

(2012) Hojae Bae et al.   Journal of Tissue Engineering and Regenerative Medicine

Nanocomposite Gold-Silk Nanofibers

(2012) Tzahi Cohen-Karni et al.   NANO LETTERS

Fibrin conduit supplemented with human mesenchymal stem cells and immunosuppressive treatment enhances regeneration after peripheral nerve injury

(2012) Aleksandra M. McGrath et al.   NEUROSCIENCE LETTERS

Mesenchymal Stem Cells in a Polycaprolactone Conduit Promote Sciatic Nerve Regeneration and Sensory Neuron Survival after Nerve Injury

(2012) Flávia Frattini et al.   TISSUE ENGINEERING PART A

Human Neural Crest Stem Cells Derived from Human ESCs and Induced Pluripotent Stem Cells: Induction, Maintenance, and Differentiation into Functional Schwann Cells

(2012) Qiuyue Liu et al.   Stem Cells Translational Medicine

Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats

(2011) W. Huang et al.   BIOMATERIALS

FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy

(2011) S. Kehoe et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Peripheral nerve regeneration using autologous porcine skin-derived mesenchymal stem cells

(2011) Bong-Wook Park et al.   Journal of Tissue Engineering and Regenerative Medicine

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

(2011) Laleh Ghasemi-Mobarakeh et al.   Journal of Tissue Engineering and Regenerative Medicine

Nerve repair with adipose-derived stem cells protects dorsal root ganglia neurons from apoptosis

(2011) A.J. Reid et al.   NEUROSCIENCE

Rapid repair of rat sciatic nerve injury using a nanosilver-embedded collagen scaffold coated with laminin and fibronectin

(2011) Tan Ding et al.   Regenerative Medicine

Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein

(2011) Mohammad T. Abu-Rub et al.   Soft Matter

Nerve growth factor (NGF)-conjugated electrospun nanostructures with topographical cues for neuronal differentiation of mesenchymal stem cells

(2010) Young Il Cho et al.   Acta Biomaterialia

Aligned natural–synthetic polyblend nanofibers for peripheral nerve regeneration

(2010) Chun-Yang Wang et al.   Acta Biomaterialia

Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit

(2010) Li Yao et al.   BIOMATERIALS

Fibrin matrices with affinity-based delivery systems and neurotrophic factors promote functional nerve regeneration

(2010) Matthew D. Wood et al.   BIOTECHNOLOGY AND BIOENGINEERING

Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration

(2010) Shohei Wakao et al.   EXPERIMENTAL NEUROLOGY

Peripheral nerve regeneration using composite poly(lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning

(2010) Jun-Jian Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

In vivo MR imaging tracking of transplanted mesenchymal stem cells in a rabbit model of acute peripheral nerve traction injury

(2010) Jun Shen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Regeneration and repair of peripheral nerves with different biomaterials: Review

(2010) Maria Siemionow et al.   MICROSURGERY

Use of Templates to Fabricate Nanoscale Spherical Structures for Defined Architectural Control

(2010) Gildas Réthoré et al.   Small

Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres

(2010) Lina Ziegler et al.   Stem Cell Reviews and Reports

Use of Tissue-Engineered Nerve Grafts Consisting of a Chitosan/Poly(lactic-co-glycolic acid)-Based Scaffold Included with Bone Marrow Mesenchymal Cells for Bridging 50-mm Dog Sciatic Nerve Gaps

(2010) Fei Ding et al.   TISSUE ENGINEERING PART A

Polymers for Fabricating Nerve Conduits

(2010) Shanfeng Wang et al.   International Journal of Polymer Science

Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering

(2009) Deepika Gupta et al.   Acta Biomaterialia

The application of nanofibrous scaffolds in neural tissue engineering

(2009) Haoqing Cao et al.   ADVANCED DRUG DELIVERY REVIEWS

US Food and Drug Administration/Conformit Europe-Approved Absorbable Nerve Conduits for Clinical Repair of Peripheral and Cranial Nerves

(2009) M F. Meek et al.   ANNALS OF PLASTIC SURGERY

Incorporation of double-walled microspheres into polymer nerve guides for the sustained delivery of glial cell line-derived neurotrophic factor

(2009) Lauren E. Kokai et al.   BIOMATERIALS

Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy

(2009) Wilson Z. Ray et al.   EXPERIMENTAL NEUROLOGY

Current applications and future perspectives of artificial nerve conduits

(2009) Xu Jiang et al.   EXPERIMENTAL NEUROLOGY

Preparation and characterization of collagen-based composite conduit for peripheral nerve regeneration

(2009) Wang Xiangmei et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration

(2009) Ming-Chin Lu et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Biodegradable fibrin conduit promotes long-term regeneration after peripheral nerve injury in adult rats

(2009) Jonas Pettersson et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Designing ideal conduits for peripheral nerve repair

(2009) Godard C. W. de Ruiter et al.   Neurosurgical Focus

Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration

(2008) Matthew D. Wood et al.   Acta Biomaterialia

Artificial nerve tubes and their application for repair of peripheral nerve injury: an update of current concepts

(2008) Satoshi Ichihara et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Schwann Cell Strip for Peripheral Nerve Repair

(2008) D. F. KALBERMATTEN et al.   Journal of Hand Surgery-European Volume

Clinical evaluation of a resorbable wrap-around implant as an alternative to nerve repair: A prospective, assessor-blinded, randomised clinical study of sensory, motor and functional recovery after peripheral nerve repair

(2008) Maria Åberg et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Antioxidant Levels Represent a Major Determinant in the Regenerative Capacity of Muscle Stem Cells

(2008) Kenneth L. Urish et al.   MOLECULAR BIOLOGY OF THE CELL

Collagen Tissue Engineering: Development of Novel Biomaterials and Applications

(2008) Lian Cen et al.   PEDIATRIC RESEARCH

Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps

(2007) Mahesh Chandra Dodla et al.   BIOMATERIALS