Article
Clinical Neurology
Xuezhen Shen, Feng Qu, Yilun Pei, Simeng Lei, Suhang Xia, Jing Liang, Shan Li, Xun Sun, Liang Liu
Summary: This study demonstrates that the combined application of functionalized self-assembling peptide gels and chitosan nerve conduits accelerates nerve healing and enhances morphological repair, providing a promising therapy for peripheral nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Fadong Liu, Fei Hao, Peng Hao, Wen Zhao, Yudan Gao, Hongmei Duan, Zhaoyang Yang, Xiaoguang Li
Summary: A novel chitosan scaffold loaded with bFGF was used to successfully repair a 20 mm sciatic nerve defect in adult rats, promoting nerve regeneration and behavioral recovery. The approach showed great potential for clinical application in treating peripheral nerve injuries.
BIOMEDICAL MATERIALS
(2021)
Article
Critical Care Medicine
Zahra Taherian Mobarakeh, Elham Hasanzadeh, Ali Farzin, Arash Goodarzi, Morteza Sagharjoghi Farahani, Sadegh Shirian, Narges Mahmoodi, Narges Zamani, Anita Karimi, Jafar Ai
Summary: This study investigated the regeneration of sciatic nerves using human endometrial stem cells (hEnSCs) encapsulated in fibrin gel containing chitosan nanoparticles loaded with insulin (Ins-CPs). The results demonstrated that the combination of these nanoparticles and stem cells significantly improved motor function and sensory recovery.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Engineering, Biomedical
Shuai Wei, Qian Hu, Jianxiong Ma, Xiu Dai, Yu Sun, Gonghai Han, Haoye Meng, Wenjing Xu, Lei Zhang, Xinlong Ma, Jiang Peng, Yu Wang
Summary: Compared to conventional artificial nerve guide conduits, acellular nerve grafts derived from natural nerves have natural advantages. In this study, a composite technology based on supercritical carbon dioxide was used to process the peripheral nerve of a large mammal and obtain acellular nerve xenografts. The extracted grafts showed improved cell adhesion and proliferation, reduced inflammatory response, and promoted nerve regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Fa-Dong Liu, Hong-Mei Duan, Fei Hao, Wen Zhao, Yu-Dan Gao, Peng Hao, Zhao-Yang Yang, Xiao-Guang Li
Summary: This study used chitosan scaffolds loaded with nerve growth factor to repair long-segment sciatic nerve defects in adult rats. The treatment significantly promoted the recovery of motor and sensory functions and reconstructed neural circuits.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Luca Scaccini, Roberta Mezzena, Alessia De Masi, Mariacristina Gagliardi, Giovanna Gambarotta, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method using chitosan scaffolds to promote nerve regeneration, showing that asymmetric directional topographies can enhance cell proliferation and migration speed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Maki Ando, Ryosuke Ikeguchi, Tomoki Aoyama, Mai Tanaka, Takashi Noguchi, Yudai Miyazaki, Shizuka Akieda, Koichi Nakayama, Shuichi Matsuda
Summary: The study compared the long-term safety and nerve regeneration of Bio3D conduit with artificial nerve conduit and autologous nerve transplantation in treating rat sciatic nerve defect. Results showed that the Bio3D group exhibited significantly better nerve regeneration compared to the silicon group, and there was no significant difference between the Bio3D group and the nerve autograft group in all endpoints.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Liangfu Jiang, Xingyu Ouyang, Dupiao Zhang, Gang Wang, Zhe Zhang, Wei Wang, Hede Yan
Summary: This study presents a Gel-Ppy modified nerve conduit with excellent biocompatibility and conductivity, and evaluates its performance in promoting nerve regeneration in vitro and in vivo. The results demonstrate that Gel-Ppy modified nerve conduit can significantly enhance Schwann cell proliferation, contribute to Schwann cell regeneration in vivo, and improve axon diameters and myelin sheath thickness, leading to the amelioration of muscle atrophy, nerve conduction, and motor function recovery. Further investigation indicates that the Gel-Ppy conduit facilitates nerve regeneration by upregulating the Rap1 pathway to induce neurite outgrowth. Therefore, Gel-Ppy modified nerve conduit can provide a favorable microenvironment for nerve regeneration and be popularized as a novel therapeutic strategy for peripheral nerve injury.
Review
Engineering, Biomedical
Yasaman Ebrahimi-kia, Parivash Davoudi, Sima Bordbar
Summary: This study offers a thorough examination of tissue engineering approaches for sciatic nerve repair, including scaffold-based techniques, cell-based therapies, and bioactive molecule delivery systems. Promising materials and strategies have been identified, but further research is needed to overcome challenges and improve the methods.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo
Summary: The natural drug lentinan has been found to regulate autophagy, promoting the clearance of myelin debris and enhancing nerve regeneration. The study demonstrated that lentinan activates the AMPK/mTOR signaling pathway, accelerating autophagic flux and promoting the phagocytosis of myelin debris by Schwann cells. These findings suggest that lentinan may be a cost-effective and natural treatment for peripheral nerve injury.
PHYTOTHERAPY RESEARCH
(2023)
Review
Health Care Sciences & Services
Maximilian Mayrhofer-Schmid, Tess T. Klemm, Martin Aman, Ulrich Kneser, Kyle R. Eberlin, Leila Harhaus, Arne H. Boecker
Summary: Wrapping peripheral nerves can prevent scar tissue formation and adhesions, but the optimal material and technique have yet to be determined. Further research is needed to identify the most effective nerve wrapping method for clinical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell & Tissue Engineering
Arman Ai, Jamileh Saremi, Somayeh Ebrahimi-Barough, Narges Fereydouni, Tara Mahmoodi, Nastaran Kazemi Rad, Pedram Sarikhani, Arash Goodarzi, Fardin Amidi
Summary: Reconstruction of nerve conduits using PCL/Taurine/Cell conduits has shown promising results in improving peripheral nerve repair. The addition of Taurine and human endothelial stem cells (hEnSCs) in the conduits has led to functional recovery of motor and sensory nerves, as well as remarkable nerve regeneration and bridging in a rat model. These findings suggest that PCL/Taurine/Cell conduits may be a suitable option for sciatic nerve regeneration.
REGENERATIVE THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yingshuai Wang, Tao Yu, Feihu Hu
Summary: This study explores the application of miRNAs and exosomes in peripheral nerve regeneration and finds that a hypocapnia environment can enhance exosome function. By delivering miR-218 through engineered exosomes, sciatic nerve regeneration can be facilitated, and hypocapnia stimuli-responsive exosomes show better results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
