Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Arbidol and other Low Molecular Weight Drugs That Inhibit Lassa and Ebola Viruses

(2019) C. E. Hulseberg et al.   JOURNAL OF VIROLOGY

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis

(2019) Gaurav Sharma et al.   Autophagy

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

(2018) Julie Dyall et al.   JOURNAL OF INFECTIOUS DISEASES

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry

(2018) Shirley Qiu et al.   VIROLOGY

Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis

(2017) Chang Chen et al.   MOLECULES

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

(2017) Elizabeth A. Nelson et al.   PLoS Neglected Tropical Diseases

Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition

(2016) Osamu Sano et al.   FEBS LETTERS

Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor

(2016) Yi-ying Chou et al.   JOURNAL OF VIROLOGY

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

(2016) Jennifer S. Spence et al.   mBio

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly

(2015) Timothy K. Soh et al.   JOURNAL OF VIROLOGY

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A

(2014) Yingying Lu et al.   Autophagy

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Lassa virus entry requires a trigger-induced receptor switch

(2014) L. T. Jae et al.   SCIENCE

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

Uptake of Rabies Virus into Epithelial Cells by Clathrin-Mediated Endocytosis Depends upon Actin

(2013) S. Piccinotti et al.   JOURNAL OF VIROLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The First Five Seconds in the Life of a Clathrin-Coated Pit

(2012) Emanuele Cocucci et al.   CELL

Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis

(2012) Yumiko Wada et al.   PLoS One

The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry

(2012) Christian D.S. Nelson et al.   VIROLOGY

Brief Report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

(2011) Sarah Krausz et al.   ARTHRITIS AND RHEUMATISM

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport

(2011) Giulia Pasqual et al.   PLoS Pathogens

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohnʼs disease

(2009) Bruce E. Sands et al.   INFLAMMATORY BOWEL DISEASES

A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry

(2009) A. C. Wong et al.   JOURNAL OF VIROLOGY

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS