PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR

Protease-activated receptor signalling initiates α5β1-integrin-mediated adhesion in non-haematopoietic cells

(2020) Patrizia M. Spoerri et al.   NATURE MATERIALS

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

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Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

(2018) Liang Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer

(2018) Vitor Hugo de Almeida et al.   Oncotarget

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer

(2017) Alice Chanakira et al.   GYNECOLOGIC ONCOLOGY

Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma

(2017) Murasaki Aman et al.   HUMAN PATHOLOGY

A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells

(2017) Yuhong Jiang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)

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Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

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A pathology atlas of the human cancer transcriptome

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In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles

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Genetic modifiers of EGFR dependence in non-small cell lung cancer

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Gαs regulates the post-endocytic sorting of G protein-coupled receptors

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Metastasis of ovarian cancer is mediated by kallikrein related peptidases

(2013) Ying Dong et al.   CLINICAL & EXPERIMENTAL METASTASIS

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

(2013) Junxian Lim et al.   FASEB JOURNAL

Protease activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP dependent manner

(2013) Kun Shi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Paclitaxel Resistance and Multicellular Spheroid Formation Are Induced by Kallikrein-Related Peptidase 4 in Serous Ovarian Cancer Cells in an Ascites Mimicking Microenvironment

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SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

(2013) Raul Aguirre-Gamboa et al.   PLoS One

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(2013) Vanessa L. Wehbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

Tissue Factor-Factor VIIa Complex Induces Epithelial Ovarian Cancer Cell Invasion and Metastasis Through a Monocytes-Dependent Mechanism

(2011) Zhengwen Ma et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Structure, function and pathophysiology of protease activated receptors

(2011) Mark N. Adams et al.   PHARMACOLOGY & THERAPEUTICS

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

(2010) F. Schaffner et al.   BLOOD

PAR1 and PAR2 Couple to Overlapping and Distinct Sets of G Proteins and Linked Signaling Pathways to Differentially Regulate Cell Physiology

(2010) K. L. McCoy et al.   MOLECULAR PHARMACOLOGY

Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

(2009) N Yokota et al.   BRITISH JOURNAL OF CANCER

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

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