Structural hybridization as a facile approach to new drug candidates

The past, present and future of anti-malarial medicines

(2019) Edwin G. Tse et al.   MALARIA JOURNAL

Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria

(2019) Aysun Çapcı et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ferrocene-Based Compounds with Antimalaria/Anticancer Activity

(2019) Sijongesonke Peter et al.   MOLECULES

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

(2018) Aysun Çapcı Karagöz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action

(2018) Tony Fröhlich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

(2018) Ronald Domalaon et al.   CLINICAL MICROBIOLOGY REVIEWS

Molecular Consortia—Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds

(2018) Lisa Gruber et al.   MOLECULES

In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model

(2018) Eric Sonntag et al.   ANTIVIRAL RESEARCH

Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine

(2018) Jigang Wang et al.   Engineering

A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria

(2017) Xuan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quinoline-Based Hybrid Compounds with Antimalarial Activity

(2017) Xhamla Nqoro et al.   MOLECULES

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

(2017) Felix E. Held et al.   Nature Communications

Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties

(2016) Surendra R. Punganuru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of novel hybrids β -carboline-4-thiazolidinones as potential antitumor and antiviral agents

(2016) Valéria Aquilino Barbosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Linkers Having a Crucial Role in Antibody–Drug Conjugates

(2016) Jun Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma

(2016) Thomas Powles et al.   JOURNAL OF CLINICAL ONCOLOGY

Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux

(2016) Bala Kishan Gorityala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

(2016) Tony Fröhlich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial

(2016) Anas Younes et al.   LANCET ONCOLOGY

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

(2015) Bala Kishan Gorityala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

(2015) Aryun Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor

(2015) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of length and flexibility of spacers on the binding affinity of divalent ligands

(2015) Susanne Liese et al.   Beilstein Journal of Organic Chemistry

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities

(2015) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

(2015) Surender Singh Jadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma

(2015) T. J. Galloway et al.   CLINICAL CANCER RESEARCH

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitroantimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

(2015) Akinobu Ito et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway

(2015) Kathy K. Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells

(2014) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on pharmacophoric designs of antiproliferative agents

(2014) Anil Rana et al.   MEDICINAL CHEMISTRY RESEARCH

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa

(2014) Gaëtan L. A. Mislin et al.   Metallomics

Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates

(2014) Ning Wang et al.   MedChemComm

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

A primaquine–chloroquine hybrid with dual activity against Plasmodium liver and blood stages

(2013) Melanie Lödige et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Structural Characteristics of Chloroquine-Bridged Ferrocenophane Analogues of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms

(2013) Paloma F. Salas et al.   JOURNAL OF MEDICINAL CHEMISTRY

The antimalarial ferroquine: from bench to clinic

(2013) C. Biot et al.   Parasite

Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program

(2013) Hernan Carol et al.   PEDIATRIC BLOOD & CANCER

Antimalarial and anticancer activities of artemisinin–quinoline hybrid-dimers and pharmacokinetic properties in mice

(2012) Marli C. Lombard et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Overview of the therapeutic potential of piplartine (piperlongumine)

(2012) Daniel P. Bezerra et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Design, Synthesis, and Antiviral Evaluation of Purine-β-lactam and Purine-aminopropanol Hybrids

(2012) Matthias D’hooghe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modular Synthesis of 1,2- and 1,1′-Disubstituted Ferrocenyl Carbohydrate Chloroquine and Mefloquine Conjugates as Potential Antimalarial Agents

(2012) Christoph Herrmann et al.   ORGANOMETALLICS

Prodrugs for improving tumor targetability and efficiency

(2011) Rubi Mahato et al.   ADVANCED DRUG DELIVERY REVIEWS

The Application of Tandem Aza-Wittig Reaction to Synthesize Artemisinin-Guanidine Hybrids and Their Anti-Tumor Activity

(2011) Lijun Xie et al.   ARCHIV DER PHARMAZIE

Synthesis and in vitro antiplasmodial activityof quinoline-ferrocene esters

(2011) David N-Da et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling

(2010) Paul P. Geurink et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity

(2010) Marli C. Lombard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity

(2010) Cheng-Jung Lai et al.   CANCER RESEARCH

Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia

(2010) Harald Noedl et al.   CLINICAL INFECTIOUS DISEASES

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer

(2010) Xiong Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Progress in the Development of Synthetic Hybrids of Natural or Unnatural Bioactive Compounds for Medicinal Chemistry

(2010) Svetlana B. Tsogoeva   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Plasmodium falciparum Drug Resistance in Madagascar: Facing the Spread of Unusual pfdhfr and pfmdr-1 Haplotypes and the Decrease of Dihydroartemisinin Susceptibility

(2009) V. Andriantsoanirina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

(2009) Desmond Slade et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hybrid Drugs for Malaria

(2009) J. Walsh et al.   CURRENT PHARMACEUTICAL DESIGN

Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics

(2009) Varvara Pokrovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Patent issues relating to hybrid drugs

(2008) John Richards   EXPERT OPINION ON THERAPEUTIC PATENTS

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH