标题
Structural hybridization as a facile approach to new drug candidates
作者
关键词
Structural hybridization, Antimalarial hybrids, Antibacterial hybrids, Anticancer hybrids, Antiviral hybrids
出版物
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 30, Issue 23, Pages 127514
出版商
Elsevier BV
发表日期
2020-08-26
DOI
10.1016/j.bmcl.2020.127514
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The past, present and future of anti-malarial medicines
- (2019) Edwin G. Tse et al. MALARIA JOURNAL
- Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria
- (2019) Aysun Çapcı et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ferrocene-Based Compounds with Antimalaria/Anticancer Activity
- (2019) Sijongesonke Peter et al. MOLECULES
- Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin
- (2018) Aysun Çapcı Karagöz et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action
- (2018) Tony Fröhlich et al. CHEMISTRY-A EUROPEAN JOURNAL
- Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?
- (2018) Ronald Domalaon et al. CLINICAL MICROBIOLOGY REVIEWS
- Molecular Consortia—Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis
- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Treatment of Multidrug-Resistant Leukemia Cells by Novel Artemisinin-, Egonol-, and Thymoquinone-Derived Hybrid Compounds
- (2018) Lisa Gruber et al. MOLECULES
- In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model
- (2018) Eric Sonntag et al. ANTIVIRAL RESEARCH
- Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
- (2018) Jigang Wang et al. Engineering
- A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria
- (2017) Xuan Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quinoline-Based Hybrid Compounds with Antimalarial Activity
- (2017) Xhamla Nqoro et al. MOLECULES
- Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
- (2017) Felix E. Held et al. Nature Communications
- Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties
- (2016) Surendra R. Punganuru et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and evaluation of novel hybrids β -carboline-4-thiazolidinones as potential antitumor and antiviral agents
- (2016) Valéria Aquilino Barbosa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Linkers Having a Crucial Role in Antibody–Drug Conjugates
- (2016) Jun Lu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma
- (2016) Thomas Powles et al. JOURNAL OF CLINICAL ONCOLOGY
- Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux
- (2016) Bala Kishan Gorityala et al. JOURNAL OF MEDICINAL CHEMISTRY
- Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents
- (2016) Tony Fröhlich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial
- (2016) Anas Younes et al. LANCET ONCOLOGY
- Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy
- (2015) Bala Kishan Gorityala et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy
- (2015) Aryun Kim et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor
- (2015) Andrew P. Tomaras et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Influence of length and flexibility of spacers on the binding affinity of divalent ligands
- (2015) Susanne Liese et al. Beilstein Journal of Organic Chemistry
- Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities
- (2015) Christoph Reiter et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors
- (2015) Surender Singh Jadav et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma
- (2015) T. J. Galloway et al. CLINICAL CANCER RESEARCH
- New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
- (2015) Christoph Reiter et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- In vitroantimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria
- (2015) Akinobu Ito et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway
- (2015) Kathy K. Wang et al. MOLECULAR BIOLOGY AND EVOLUTION
- Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
- (2015) Nicholas Butowski et al. NEURO-ONCOLOGY
- Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
- (2014) Kunal Nepali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms
- (2014) Zhu-Ping Xiao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells
- (2014) Christoph Reiter et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A review on pharmacophoric designs of antiproliferative agents
- (2014) Anil Rana et al. MEDICINAL CHEMISTRY RESEARCH
- Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa
- (2014) Gaëtan L. A. Mislin et al. Metallomics
- Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates
- (2014) Ning Wang et al. MedChemComm
- Advances in the development of hybrid anticancer drugs
- (2013) Sébastien Fortin et al. Expert Opinion on Drug Discovery
- Clinical relevance of the ESKAPE pathogens
- (2013) Jack N Pendleton et al. Expert Review of Anti-Infective Therapy
- A primaquine–chloroquine hybrid with dual activity against Plasmodium liver and blood stages
- (2013) Melanie Lödige et al. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- Structural Characteristics of Chloroquine-Bridged Ferrocenophane Analogues of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms
- (2013) Paloma F. Salas et al. JOURNAL OF MEDICINAL CHEMISTRY
- The antimalarial ferroquine: from bench to clinic
- (2013) C. Biot et al. Parasite
- Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program
- (2013) Hernan Carol et al. PEDIATRIC BLOOD & CANCER
- Antimalarial and anticancer activities of artemisinin–quinoline hybrid-dimers and pharmacokinetic properties in mice
- (2012) Marli C. Lombard et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Overview of the therapeutic potential of piplartine (piperlongumine)
- (2012) Daniel P. Bezerra et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Design, Synthesis, and Antiviral Evaluation of Purine-β-lactam and Purine-aminopropanol Hybrids
- (2012) Matthias D’hooghe et al. JOURNAL OF MEDICINAL CHEMISTRY
- Modular Synthesis of 1,2- and 1,1′-Disubstituted Ferrocenyl Carbohydrate Chloroquine and Mefloquine Conjugates as Potential Antimalarial Agents
- (2012) Christoph Herrmann et al. ORGANOMETALLICS
- Prodrugs for improving tumor targetability and efficiency
- (2011) Rubi Mahato et al. ADVANCED DRUG DELIVERY REVIEWS
- The Application of Tandem Aza-Wittig Reaction to Synthesize Artemisinin-Guanidine Hybrids and Their Anti-Tumor Activity
- (2011) Lijun Xie et al. ARCHIV DER PHARMAZIE
- Synthesis and in vitro antiplasmodial activityof quinoline-ferrocene esters
- (2011) David N-Da et al. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling
- (2010) Paul P. Geurink et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity
- (2010) Marli C. Lombard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity
- (2010) Cheng-Jung Lai et al. CANCER RESEARCH
- Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia
- (2010) Harald Noedl et al. CLINICAL INFECTIOUS DISEASES
- Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer
- (2010) Xiong Cai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent Progress in the Development of Synthetic Hybrids of Natural or Unnatural Bioactive Compounds for Medicinal Chemistry
- (2010) Svetlana B. Tsogoeva MINI-REVIEWS IN MEDICINAL CHEMISTRY
- The Molecular Mechanism of Action of Artemisinin—The Debate Continues
- (2010) Paul M. O’Neill et al. MOLECULES
- Plasmodium falciparum Drug Resistance in Madagascar: Facing the Spread of Unusual pfdhfr and pfmdr-1 Haplotypes and the Decrease of Dihydroartemisinin Susceptibility
- (2009) V. Andriantsoanirina et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers
- (2009) Desmond Slade et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Hybrid Drugs for Malaria
- (2009) J. Walsh et al. CURRENT PHARMACEUTICAL DESIGN
- Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics
- (2009) Varvara Pokrovskaya et al. JOURNAL OF MEDICINAL CHEMISTRY
- Patent issues relating to hybrid drugs
- (2008) John Richards EXPERT OPINION ON THERAPEUTIC PATENTS
- Drug interactions modulate the potential for evolution of resistance
- (2008) J.-B. Michel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†
- (2007) Bernard Meunier ACCOUNTS OF CHEMICAL RESEARCH
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