Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity

Inhibition effects of some pesticides and heavy metals on carbonic anhydrase enzyme activity purified from horse mackerel (Trachurus trachurus) gill tissues

(2020) Cuneyt Caglayan et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Synthesis and Structure–Activity Relationship of Pyxinol Derivatives as Novel Anti-Inflammatory Agents

(2020) Yixiao Sun et al.   ACS Medicinal Chemistry Letters

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

(2020) Cuizhu Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-choline diet exacerbates cardiac dysfunction, fibrosis, and inflammation in a mouse model of heart failure with preserved ejection fraction

(2020) Wei Shuai et al.   JOURNAL OF CARDIAC FAILURE

Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure

(2020) Hailian Quan et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds – Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibition properties

(2020) İlhami Gülçin et al.   BIOORGANIC CHEMISTRY

Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL‐60, THP‐1, and PC‐3 Cell Lines

(2019) Ziyi Wang et al.   CHEMISTRY & BIODIVERSITY

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

(2019) Satoshi Maekawa et al.   Cell Communication and Signaling

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

(2019) Thong H. Cao et al.   EUROPEAN JOURNAL OF HEART FAILURE

The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos

(2019) Jing Fu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats

(2019) Meichen Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice

(2019) Xu Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Integrated UPLC-Q/TOF-MS Technique and MALDI-MS to Study of the Efficacy of YiXinshu Capsules Against Heart Failure in a Rat Model

(2019) Jing Xu et al.   Frontiers in Pharmacology

A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways

(2018) Fan Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In silico analysis and molecular docking study of angiotensin I-converting enzyme inhibitory peptides from smooth-hound viscera protein hydrolysates fractionated by ultrafiltration

(2018) Ola Abdelhedi et al.   FOOD CHEMISTRY

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis

(2018) Yaru Wang et al.   MOLECULES

Developmental and metabolic responses of zebrafish ( Danio rerio ) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure

(2018) Xiaoqian Ren et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Metabolomic assessment of arsenite toxicity and novel biomarker discovery in early development of zebrafish embryos

(2018) Szu-Yuan Wu et al.   TOXICOLOGY LETTERS

A Zebrafish Heart Failure Model for Assessing Therapeutic Agents

(2018) Xiao-Yu Zhu et al.   Zebrafish

Synopsis of arachidonic acid metabolism: A review

(2018) Violette Said Hanna et al.   Journal of Advanced Research

Simplified plasma essential amino acid-based profiling provides metabolic information and prognostic value additive to traditional risk factors in heart failure

(2018) Chao-Hung Wang et al.   AMINO ACIDS

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones

(2018) Mehtap Tugrak et al.   BIOORGANIC CHEMISTRY

Investigation of the effects of cephalosporin antibiotics on glutathione S-transferase activity in different tissues of rats in vivo conditions in order to drug development research

(2018) Fikret Türkan et al.   DRUG AND CHEMICAL TOXICOLOGY

Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance

(2018) Qianwen Ren et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Antibacterial Evaluation of 3-Substituted Ocotillol-Type Derivatives

(2018) Kai-Yi Wang et al.   MOLECULES

Design, synthesis and biological evaluation of Schiff bases of 4-amino-1,2,4-triazole derivatives as potent angiotensin converting enzyme inhibitors and antioxidant activities

(2018) Ikram Saadaoui et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity

(2018) Dilan Ozmen Ozgun et al.   BIOORGANIC CHEMISTRY

Metabolic disruption of zebrafish ( Danio rerio ) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach

(2017) Elena Ortiz-Villanueva et al.   ENVIRONMENTAL POLLUTION

Prostaglandin E2 Signaling as a Target of Anti-Cardiac Fibrosis in Heart Failure Treatment

(2017) Mutsuo Harada et al.   International Heart Journal

Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(α-aminoalkyl)phosphinic acid derivatives against human breast cancer

(2017) Taner Dastan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Heart failure

(2017) Marco Metra et al.   LANCET

A novel antioxidant and ACE inhibitory peptide from rice bran protein: Biochemical characterization and molecular docking study

(2017) Xiuming Wang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Synthesis and crystal structure of ocotillol-type metabolites derived from (20R)-protopanaxadiol

(2017) Zhi Liu et al.   JOURNAL OF CHEMICAL RESEARCH

Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine

(2017) Gyojeong Gu et al.   Korean Circulation Journal

Prostaglandin E2 Reduces Cardiac Contractility via EP3 ReceptorCLINICAL PERSPECTIVE

(2016) Xiaosong Gu et al.   Circulation-Heart Failure

High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy

(2016) Jiung-Pang Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines

(2016) Kaan Kucukoglu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism

(2016) Chun Li et al.   Scientific Reports

Design and synthesis of 3-(3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)-2-phenylquinazolin-4(3H)-one derivatives to induce ACE inhibitory activity

(2015) Ramineni Venkatesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives

(2015) Yi Bi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme

(2015) Tran Hai-Bang et al.   Phytochemistry Letters

Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol

(2015) Ning Li et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4

(2014) Yong Wang et al.   BMC Complementary and Alternative Medicine

Stereoselective Formation and Metabolism of 20(S)-Protopanaxadiol Ocotillol Type Epimers in Vivo and in Vitro

(2014) Wenyan Wang et al.   CHIRALITY

Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers

(2014) Praveen Kumar Kalavagunta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shengxian decoction in chronic heart failure treatment and synergistic property of platycodonis radix: a metabolomic approach and its application

(2014) Feng Zhang et al.   Molecular BioSystems

Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors

(2013) Dinesh Addla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

2013 ACCF/AHA Guideline for the Management of Heart Failure

(2013) Clyde W. Yancy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure

(2012) M Knapp et al.   Advances in Medical Sciences

Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives

(2012) Peng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural modification of ginsenoside Rh2 by fatty acid esterification and its detoxification property in antitumor

(2011) Gong-Qing Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Zebrafish as a model to study cardiac development and human cardiac disease

(2011) J. Bakkers   CARDIOVASCULAR RESEARCH

Angiotensin-converting enzymes and drug discovery in cardiovascular diseases

(2010) Lijun Shi et al.   DRUG DISCOVERY TODAY

Identification of 20(S)-Protopanaxadiol Metabolites in Human Liver Microsomes and Human Hepatocytes

(2010) L. Li et al.   DRUG METABOLISM AND DISPOSITION

Study on the structure–function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol

(2010) Tian Wang et al.   FITOTERAPIA

Angiotensin I-converting enzyme (ACE) inhibitory peptides derived from arachin by simulated gastric digestion

(2010) V.K. Jimsheena et al.   FOOD CHEMISTRY

Colorimetric, High-Throughput Assay for Screening Angiotensin I-Converting Enzyme Inhibitors

(2009) V. K. Jimsheena et al.   ANALYTICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Antioxidant diterpenoids from the roots ofSalvia barrelieri

(2009) Ufuk Kolak et al.   PHYTOCHEMICAL ANALYSIS

Significance of the zebrafish model in the discovery of bioactive molecules from nature

(2008) Noopur Mandrekar et al.   BIOTECHNOLOGY LETTERS

Optimization of Lipase-Catalyzed Synthesis of Ginsenoside Rb1 Esters Using Response Surface Methodology

(2008) Jiang-Ning Hu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula

(2007) G.P.P. Kamatou et al.   SOUTH AFRICAN JOURNAL OF BOTANY